Basic Information:

  VIRBase ID:  

HHID00004933

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          AJAP1:  NM_018836     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	AJAP1
miRBase Accession/Entrez ID	MIMAT0000458	55966
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	MOT8//SHREW-1//SHREW1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	AJAP1	chr1:4799256(+) A-I      intronic chr1:4799249(+) A-I      intronic chr1:4799288(+) A-I      intronic chr1:4799276(+) A-I      intronic chr1:4799246(+) A-I      intronic chr1:4840096(+) A-I      intronic chr1:4840083(+) A-I      intronic chr1:4808727(+) A-I      intronic chr1:4840093(+) A-I      intronic chr1:4840084(+) A-I      intronic chr1:4775625(+) A-I      intronic chr1:4748852(+) A-I      intronic chr1:4840132(+) A-I      intronic chr1:4840796(+) A-I      intronic chr1:4718597(+) A-I      intronic chr1:4840831(+) A-I      intronic chr1:4840129(+) A-I      intronic chr1:4840821(+) A-I      intronic chr1:4840854(+) A-I      intronic chr1:4840089(+) A-I      intronic chr1:4840792(+) A-I      intronic chr1:4840810(+) A-I      intronic chr1:4840125(+) A-I      intronic chr1:4840027(+) A-I      intronic chr1:4796941(+) A-I      intronic chr1:4840029(+) A-I      intronic chr1:4840058(+) A-I      intronic chr1:4840081(+) A-I      intronic chr1:4840124(+) A-I      intronic chr1:4797223(+) A-I      intronic chr1:4775666(+) A-I      intronic chr1:4840043(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	AJAP1	chr1:4839048(+) A-I intron -    15342557 chr1:4839652(+) A-I intron -    15342557 chr1:4840029(+) A-I intron -    15342557 chr1:4840043(+) A-I intron -    15342557 chr1:4840058(+) A-I intron -    15342557 chr1:4840081(+) A-I intron -    15342557 chr1:4840083(+) A-I intron -    15342557 chr1:4840084(+) A-I intron -    15342557 chr1:4840089(+) A-I intron -    15342557 chr1:4840093(+) A-I intron -    15342557 chr1:4840124(+) A-I intron -    15342557 chr1:4840125(+) A-I intron -    15342557 chr1:4840129(+) A-I intron -    15342557

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	AJAP1	chr1:4772136-4772137(+) m6A CDS//exon       25456834 chr1:4772246-4772247(+) m6A CDS       25456834 chr1:4772277-4772278(+) m6A CDS       25456834 chr1:4772461-4772462(+) m6A CDS       25456834 chr1:4772560-4772561(+) m6A CDS       25456834 chr1:4772569-4772570(+) m6A CDS       25456834 chr1:4842618-4842619(+) m6A 3'UTR       25456834//24981863 chr1:4842628-4842629(+) m6A 3'UTR       25456834//24981863 chr1:4842633-4842634(+) m6A 3'UTR       25456834//24981863 chr1:4842642-4842643(+) m6A 3'UTR       25456834//24981863 chr1:4842647-4842648(+) m6A 3'UTR       25456834//24981863 chr1:4842656-4842657(+) m6A 3'UTR       25456834//24981863 chr1:4842661-4842662(+) m6A 3'UTR       25456834//24981863 chr1:4842668-4842669(+) m6A 3'UTR       25456834//24981863 chr1:4842726-4842727(+) m6A 3'UTR       25456834//24981863 chr1:4842819-4842820(+) m6A 3'UTR       25456834//24981863 chr1:4842845-4842846(+) m6A 3'UTR       25456834//24981863 chr1:4842901-4842902(+) m6A 3'UTR       24981863 chr1:4842927-4842928(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	AJAP1	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: AJAP1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).