Detail Information

Basic Information:


  VIRBase ID:  

HHID00004887

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:           FKBP14:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-5p FKBP14
miRBase
Accession/Entrez ID		 MIMAT0000458 55033
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - EDSKMH//EDSKSCL2//FKBP22//IPBP12

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-5p
rs1018706777 chr15:62823984    A/G
rs1369926402 chr15:62823991    G/A
rs1555521311 chr15:62823990    G/C
rs755866868 chr15:62823986    A/G
rs766742872 chr15:62823990    GGTT/G
rs777464613 chr15:62823987    T/G
rs1228899174 chr15:62823974    T/A
rs1281303771 chr15:62823976    T/C
rs1350000299 chr15:62823972    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR FKBP14
chr7:30054951(-) A-I      intronic
chr7:30054952(-) A-I      intronic
chr7:30057019(-) A-I      intronic
chr7:30054987(-) A-I      intronic
chr7:30054993(-) A-I      intronic
chr7:30063032(-) A-I      intronic
chr7:30057133(-) A-I      intronic
chr7:30057444(-) A-I      intronic
chr7:30055020(-) A-I      intronic
chr7:30057045(-) A-I      intronic
chr7:30056943(-) A-I      intronic
chr7:30056930(-) A-I      intronic
chr7:30054958(-) A-I      intronic
chr7:30055028(-) A-I      intronic
chr7:30050830(-) A-I      3'UTR
chr7:30050834(-) A-I      3'UTR
chr7:30051271(-) A-I      3'UTR
chr7:30050860(-) A-I      3'UTR
chr7:30050858(-) A-I      3'UTR
chr7:30050832(-) A-I      3'UTR
chr7:30050839(-) A-I      3'UTR
chr7:30050789(-) A-I      3'UTR
chr7:30050836(-) A-I      3'UTR
chr7:30050845(-) A-I      3'UTR
chr7:30050861(-) A-I      3'UTR
chr7:30051295(-) A-I      3'UTR
chr7:30051322(-) A-I      3'UTR
chr7:30050835(-) A-I      3'UTR
chr7:30050852(-) A-I      3'UTR
chr7:30057224(-) A-I      intronic
chr7:30057461(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase FKBP14
chr7:30050313-30050314(-) m6A 3'UTR       27773535
chr7:30053450-30053451(-) m6A 3'UTR       24981863//27773535
chr7:30053464-30053465(-) m6A 3'UTR       24981863//27773535
chr7:30053500-30053501(-) m6A 3'UTR       24981863//27773535//22608085
chr7:30053528-30053529(-) m6A 3'UTR       24981863//27773535//22608085
chr7:30053574-30053575(-) m6A 3'UTR       24981863//27773535//22608085
chr7:30053671-30053672(-) m6A 3'UTR       24981863
chr7:30053694-30053695(-) m6A 3'UTR       24981863
chr7:30053788-30053789(-) m6A 3'UTR       24981863//22608085
chr7:30053846-30053847(-) m6A 3'UTR       24981863//22608085
chr7:30053868-30053869(-) m6A 3'UTR       24981863//22608085
chr7:30054124-30054125(-) m6A 3'UTR       24981863//22608085
chr7:30054132-30054133(-) m6A 3'UTR       24981863//22608085
chr7:30054210-30054211(-) m6A 3'UTR       24981863//22608085
chr7:30054365-30054366(-) m6A 3'UTR//CDS       24981863//27773535
chr7:30054405-30054406(-) m6A 3'UTR//CDS       24981863//27773535
chr7:30054476-30054477(-) m6A 3'UTR//CDS       24981863//27773535
chr7:30058626-30058627(-) m6A 3'UTR//CDS       24981863//27773535
chr7:30058677-30058678(-) m6A 3'UTR//CDS       27773535
chr7:30066000-30066001(-) m6A CDS//exon       24284625
chr7:30066052-30066053(-) m6A CDS//exon       24284625
chr7:30066146-30066147(-) m6A 5'UTR//exon       24284625//24981863//22608085
chr7:30066168-30066169(-) m6A 5'UTR//exon       24284625//24981863//22608085
chr7:30066198-30066199(-) m6A 5'UTR//exon       24284625//24981863//22608085
chr7:30066230-30066231(-) m6A 5'UTR//exon       24284625//24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-5p
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
FKBP14
Chromatin K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-5p
Interactor2: FKBP14

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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