Detail Information

Basic Information:


  VIRBase ID:  

HHID00004886

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:           PHIP:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-5p PHIP
miRBase
Accession/Entrez ID		 MIMAT0000458 55023
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BRWD2//CHUJANS//DCAF14//DIDOD//ndrp//WDR11

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-5p
rs1018706777 chr15:62823984    A/G
rs1369926402 chr15:62823991    G/A
rs1555521311 chr15:62823990    G/C
rs755866868 chr15:62823986    A/G
rs766742872 chr15:62823990    GGTT/G
rs777464613 chr15:62823987    T/G
rs1228899174 chr15:62823974    T/A
rs1281303771 chr15:62823976    T/C
rs1350000299 chr15:62823972    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PHIP
chr6:79659527(-) A-I      intronic
chr6:79659560(-) A-I      intronic
chr6:79659530(-) A-I      intronic
chr6:79659534(-) A-I      intronic
chr6:79659539(-) A-I      intronic
chr6:79659544(-) A-I      intronic
chr6:79659569(-) A-I      intronic
chr6:79659574(-) A-I      intronic
chr6:79659575(-) A-I      intronic
chr6:79659576(-) A-I      intronic
chr6:79733011(-) A-I      intronic
chr6:79733014(-) A-I      intronic
chr6:79732920(-) A-I      intronic
chr6:79733023(-) A-I      intronic
chr6:79734475(-) A-I      intronic
chr6:79739371(-) A-I      intronic
chr6:79739375(-) A-I      intronic
chr6:79773327(-) A-I      intronic
chr6:79773328(-) A-I      intronic
chr6:79773337(-) A-I      intronic
chr6:79776694(-) A-I      intronic
chr6:79778010(-) A-I      intronic
chr6:79776876(-) A-I      intronic
chr6:79704182(-) A-I      intronic
chr6:79776877(-) A-I      intronic
chr6:79661968(-) A-I      intronic
chr6:79777962(-) A-I      intronic
chr6:79777963(-) A-I      intronic
chr6:79662129(-) A-I      intronic
chr6:79778056(-) A-I      intronic
chr6:79777968(-) A-I      intronic
chr6:79777997(-) A-I      intronic
chr6:79658319(-) A-I      intronic
chr6:79658462(-) A-I      intronic
chr6:79661903(-) A-I      intronic
chr6:79662053(-) A-I      intronic
chr6:79663522(-) A-I      intronic
chr6:79663558(-) A-I      intronic
chr6:79663570(-) A-I      intronic
chr6:79664041(-) A-I      intronic
chr6:79664052(-) A-I      intronic
chr6:79701764(-) A-I      intronic
chr6:79701863(-) A-I      intronic
chr6:79701953(-) A-I      intronic
chr6:79704127(-) A-I      intronic
chr6:79704130(-) A-I      intronic
chr6:79704194(-) A-I      intronic
chr6:79704038(-) A-I      intronic
chr6:79731089(-) A-I      intronic
chr6:79776899(-) A-I      intronic
chr6:79664095(-) A-I      intronic
chr6:79778093(-) A-I      intronic
chr6:79662024(-) A-I      intronic
chr6:79731068(-) A-I      intronic
chr6:79659602(-) A-I      intronic
chr6:79659503(-) A-I      intronic
chr6:79782361(-) A-I      intronic
chr6:79776883(-) A-I      intronic
chr6:79663499(-) A-I      intronic
chr6:79739385(-) A-I      intronic
chr6:79704105(-) A-I      intronic
chr6:79662076(-) A-I      intronic
chr6:79776803(-) A-I      intronic
chr6:79661981(-) A-I      intronic
chr6:79658309(-) A-I      intronic
chr6:79661956(-) A-I      intronic
chr6:79734340(-) A-I      intronic
chr6:79661992(-) A-I      intronic
chr6:79658340(-) A-I      intronic
chr6:79734332(-) A-I      intronic
chr6:79746586(-) A-I      intronic
chr6:79704225(-) A-I      intronic
chr6:79731001(-) A-I      intronic
chr6:79731060(-) A-I      intronic
chr6:79732906(-) A-I      intronic
chr6:79732934(-) A-I      intronic
chr6:79773329(-) A-I      intronic
chr6:79732936(-) A-I      intronic
chr6:79658407(-) A-I      intronic
chr6:79701952(-) A-I      intronic
chr6:79756510(-) A-I      intronic
chr6:79658243(-) A-I      intronic
chr6:79731061(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PHIP
chr6:79646611(-) A-I exon 3'UTR    19478186
chr6:79659570(-) A-I intron -    21960545
chr6:79659602(-) A-I intron -    21960545
chr6:79724742(-) A-I intron -    21960545
chr6:79659430(-) T-C intron -    22484847
chr6:79659454(-) T-C intron -    22484847
chr6:79659503(-) A-G intron -    22484847
chr6:79659602(-) A-G intron -    22484847
chr6:79661956(-) A-G intron -    22484847
chr6:79661981(-) A-G intron -    22484847
chr6:79663849(-) A-G intron -    22484847
chr6:79663947(-) A-G intron -    22484847
chr6:79701952(-) A-G intron -    22484847
chr6:79701959(-) A-G intron -    22484847
chr6:79704105(-) A-G intron -    22484847
chr6:79704225(-) A-G intron -    22484847
chr6:79731001(-) A-G intron -    22484847
chr6:79731060(-) A-G intron -    22484847
chr6:79731061(-) A-G intron -    22484847
chr6:79731068(-) A-G intron -    22484847
chr6:79734332(-) A-G intron -    22484847
chr6:79734340(-) A-G intron -    22484847
chr6:79758890(-) T-G intron -    22484847
chr6:79776881(-) A-G intron -    22484847
chr6:79776883(-) A-G intron -    22484847
chr6:79776899(-) A-G intron -    22484847
chr6:79777923(-) A-G intron -    22484847
chr6:79778097(-) G-A intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PHIP
chr6:79646431-79646432(-) m6A 3'UTR       24981863
chr6:79646465-79646466(-) m6A 3'UTR       24981863
chr6:79648652-79648653(-) m6A 3'UTR       27773535
chr6:79648769-79648770(-) m6A 3'UTR       27773535
chr6:79649302-79649303(-) m6A 3'UTR       27773535
chr6:79649638-79649639(-) m6A 3'UTR       22608085
chr6:79649680-79649681(-) m6A 3'UTR       24284625//24981863//22608085
chr6:79649724-79649725(-) m6A 3'UTR       24284625//24981863//22608085
chr6:79649748-79649749(-) m6A 3'UTR       24284625//24981863//22608085
chr6:79649766-79649767(-) m6A 3'UTR       24284625//24981863//22608085
chr6:79649794-79649795(-) m6A 3'UTR       24981863//22608085
chr6:79650252-79650253(-) m6A 3'UTR       22608085
chr6:79650265-79650266(-) m6A 3'UTR//exon       27773535//22608085
chr6:79650347-79650348(-) m6A 3'UTR//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr6:79650474-79650475(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr6:79650494-79650495(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr6:79650552-79650553(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr6:79650573-79650574(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr6:79650586-79650587(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr6:79650601-79650602(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr6:79650711-79650712(-) m6A CDS//exon       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr6:79650783-79650784(-) m6A CDS//exon       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr6:79650949-79650950(-) m6A CDS//exon       24284625//24209618//24981863//28052920//27773535//22575960//22608085
chr6:79650961-79650962(-) m6A CDS//exon       24284625//24209618//24981863//28052920//27773535//22575960//22608085
chr6:79650976-79650977(-) m6A CDS//exon       24284625//24209618//24981863//28052920//27773535//22575960//22608085
chr6:79650988-79650989(-) m6A CDS//exon       24284625//24981863//28052920//27773535//22608085
chr6:79651014-79651015(-) m6A CDS//exon       24284625//24981863//28052920//27773535//22608085
chr6:79651034-79651035(-) m6A CDS//exon       24284625//24981863//28052920//27773535//22608085
chr6:79655111-79655112(-) m6A CDS//exon       24284625//24981863//27773535//22608085
chr6:79655194-79655195(-) m6A CDS//exon       24284625//27773535//27371828//22608085
chr6:79655720-79655721(-) m6A CDS//exon       24284625//27773535//27371828//22608085
chr6:79655762-79655763(-) m6A CDS//exon       24284625//27371828//22608085
chr6:79655831-79655832(-) m6A CDS//exon       24284625//24981863//27371828//22608085
chr6:79655855-79655856(-) m6A CDS//exon       24284625//24981863//27371828//22608085
chr6:79655883-79655884(-) m6A CDS//exon       24284625//24981863//27773535//22608085
chr6:79655949-79655950(-) m6A CDS//exon       24981863//27773535
chr6:79656463-79656464(-) m6A CDS//exon       27773535
chr6:79665625-79665626(-) m6A exon//intron       27773535
chr6:79665638-79665639(-) m6A exon//intron       27773535
chr6:79665678-79665679(-) m6A exon//intron       27773535
chr6:79665704-79665705(-) m6A exon//intron       27773535
chr6:79665751-79665752(-) m6A exon//intron       27773535
chr6:79665798-79665799(-) m6A exon//intron       27773535
chr6:79665837-79665838(-) m6A exon//intron       27773535
chr6:79665917-79665918(-) m6A exon//intron       27773535
chr6:79665974-79665975(-) m6A exon//intron       27773535
chr6:79666054-79666055(-) m6A exon//intron       27773535
chr6:79666066-79666067(-) m6A exon//intron       27773535
chr6:79666150-79666151(-) m6A exon//intron       27773535
chr6:79666467-79666468(-) m6A exon//intron       27773535
chr6:79666573-79666574(-) m6A exon//intron       27773535
chr6:79680524-79680525(-) m6A CDS//exon       27773535
chr6:79680584-79680585(-) m6A CDS//exon       27773535
chr6:79688410-79688411(-) m6A CDS//exon       24981863//27773535//22608085
chr6:79692608-79692609(-) m6A CDS//exon       24981863//27773535//22608085
chr6:79692647-79692648(-) m6A CDS//exon       24981863//27773535//22608085
chr6:79692692-79692693(-) m6A CDS       24981863//27773535//22608085
chr6:79692704-79692705(-) m6A CDS       24981863//27773535//22608085
chr6:79692751-79692752(-) m6A CDS       24981863//27773535//22608085
chr6:79692805-79692806(-) m6A CDS       24981863//27773535//22608085
chr6:79695104-79695105(-) Am CDS       -
chr6:79695114-79695115(-) m6A CDS       24981863//27773535//22575960
chr6:79697964-79697965(-) m6A CDS       24981863//27773535
chr6:79697972-79697973(-) m6A CDS       24981863//27773535
chr6:79698014-79698015(-) m6A CDS       24981863//27773535
chr6:79700629-79700630(-) m6A CDS       24981863//27773535
chr6:79700655-79700656(-) m6A CDS       24981863//27773535
chr6:79700666-79700667(-) m1A CDS       26863196
chr6:79700682-79700683(-) m6A CDS       24981863//27773535
chr6:79707252-79707253(-) m6A CDS       24981863//27773535//22575960
chr6:79707267-79707268(-) m6A CDS       24981863//27773535//22575960
chr6:79708040-79708041(-) m6A CDS       -
chr6:79708056-79708057(-) m6A CDS       -
chr6:79708077-79708078(-) m6A CDS       -
chr6:79725494-79725495(-) m6A CDS       24981863
chr6:79752579-79752580(-) m6A CDS       22575960
chr6:79752616-79752617(-) m6A CDS       22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-5p
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
PHIP
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Membrane HCC cell line (HepG2)|K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-5p
Interactor2: PHIP

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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