Detail Information

Basic Information:


  VIRBase ID:  

HHID00004885

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:           PAK1IP1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-5p PAK1IP1
miRBase
Accession/Entrez ID		 MIMAT0000458 55003
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - bA421M1.5//hPIP1//MAK11//PIP1//WDR84

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-5p
rs1018706777 chr15:62823984    A/G
rs1369926402 chr15:62823991    G/A
rs1555521311 chr15:62823990    G/C
rs755866868 chr15:62823986    A/G
rs766742872 chr15:62823990    GGTT/G
rs777464613 chr15:62823987    T/G
rs1228899174 chr15:62823974    T/A
rs1281303771 chr15:62823976    T/C
rs1350000299 chr15:62823972    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PAK1IP1
chr6:10701484(+) A-I      intronic
chr6:10700525(+) A-I      intronic
chr6:10701409(+) A-I      intronic
chr6:10700392(+) A-I      intronic
chr6:10701451(+) A-I      intronic
chr6:10700409(+) A-I      intronic
chr6:10701384(+) A-I      intronic
chr6:10701427(+) A-I      intronic
chr6:10698030(+) A-I      intronic
chr6:10700526(+) A-I      intronic
chr6:10704532(+) A-I      intronic
chr6:10705286(+) A-I      intronic
chr6:10698068(+) A-I      intronic
chr6:10703120(+) A-I      intronic
chr6:10702398(+) A-I      intronic
chr6:10701532(+) A-I      intronic
chr6:10705289(+) A-I      intronic
chr6:10699326(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PAK1IP1
chr6:10705003(+) A-G exon CDS    21725310
chr6:10701350(+) A-G intron -    22484847
chr6:10703120(+) A-T intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PAK1IP1
chr6:10697562-10697563(+) m6A CDS       24284625//24981863//22575960
chr6:10703685-10703686(+) m6A CDS       24981863
chr6:10704805-10704806(+) m6A CDS       24981863
chr6:10709216-10709217(+) m6A CDS       27773535
chr6:10709255-10709256(+) m6A CDS       24981863//27773535
chr6:10709267-10709268(+) m6A CDS       24981863//27773535
chr6:10709480-10709481(+) m6A CDS       24981863//27773535//22608085
chr6:10709543-10709544(+) m6A CDS       24209618//24981863//27773535//22608085
chr6:10709673-10709674(+) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr6:10709707-10709708(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr6:10709813-10709814(+) m6A 3'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-5p
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
PAK1IP1
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-5p
Interactor2: PAK1IP1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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