Detail Information

Basic Information:


  VIRBase ID:  

HHID00004868

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:           GTPBP2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-5p GTPBP2
miRBase
Accession/Entrez ID		 MIMAT0000458 54676
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - JABELS

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-5p
rs1018706777 chr15:62823984    A/G
rs1369926402 chr15:62823991    G/A
rs1555521311 chr15:62823990    G/C
rs755866868 chr15:62823986    A/G
rs766742872 chr15:62823990    GGTT/G
rs777464613 chr15:62823987    T/G
rs1228899174 chr15:62823974    T/A
rs1281303771 chr15:62823976    T/C
rs1350000299 chr15:62823972    G/A

RNA Editing:


Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED GTPBP2
chr6:43590898(-) G-T intron -    22484847
chr6:43590986(-) C-T intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase GTPBP2
chr6:43588338-43588339(-) m6A 3'UTR//exon//intron       24209618//25456834//24981863//27773535
chr6:43588377-43588378(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22608085
chr6:43588428-43588429(-) m6A 3'UTR//exon//intron       24284625//24209618//24981863//27773535//22608085
chr6:43588480-43588481(-) m6A 3'UTR//exon//intron       24284625//24209618//24981863//27773535
chr6:43588540-43588541(-) m6A 3'UTR//exon//intron       24284625//24209618//24981863//27773535
chr6:43588823-43588824(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22608085
chr6:43588892-43588893(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22608085
chr6:43589024-43589025(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr6:43589097-43589098(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr6:43589151-43589152(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr6:43589190-43589191(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr6:43589334-43589335(-) m6A 3'UTR//exon//intron       24284625//25456834//24981863//22575960//22608085
chr6:43589349-43589350(-) m6A 3'UTR//exon//intron       24284625//25456834//24981863//22575960//22608085
chr6:43589446-43589447(-) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr6:43589476-43589477(-) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//27773535//27371828//22608085
chr6:43589514-43589515(-) m6A 3'UTR//CDS//exon       24284625//25456834//27773535//27371828//22608085
chr6:43589525-43589526(-) m6A 3'UTR//CDS//exon       24284625//25456834//27773535//27371828//22608085
chr6:43589569-43589570(-) m6A 3'UTR//intron       24981863//27773535//27371828
chr6:43589640-43589641(-) m6A CDS//intron       24981863//27773535
chr6:43589667-43589668(-) m6A CDS//intron       24981863//27773535
chr6:43589678-43589679(-) m6A CDS//intron       24981863//27773535
chr6:43589729-43589730(-) m6A CDS//intron       27773535
chr6:43591214-43591215(-) m6A exon//intron       27773535
chr6:43591287-43591288(-) m6A exon//intron       27773535
chr6:43591696-43591697(-) m6A CDS//exon       24284625//27773535
chr6:43591757-43591758(-) m6A CDS//exon       24284625//27773535
chr6:43592361-43592362(-) m6A CDS//exon       24284625//27773535
chr6:43592376-43592377(-) m6A CDS//exon       24284625//27773535
chr6:43592449-43592450(-) m6A CDS//exon       24284625//27773535
chr6:43592774-43592775(-) m6A CDS//exon       24284625//24209618//27773535
chr6:43592966-43592967(-) m6A exon//intron       24981863//27773535//22608085
chr6:43592973-43592974(-) m6A exon//intron       24981863//27773535//22608085
chr6:43593009-43593010(-) m6A exon//intron       24981863//27773535//22608085
chr6:43593035-43593036(-) m6A exon//intron       24981863//27773535//27371828//22608085
chr6:43593065-43593066(-) m6A exon//intron       24284625//24981863//27773535//27371828//22608085
chr6:43593080-43593081(-) m6A exon//intron       24284625//24981863//27773535//27371828
chr6:43593146-43593147(-) m6A CDS//exon       27773535//27371828//27773536
chr6:43593211-43593212(-) m6A CDS//exon       27773535//27773536
chr6:43593259-43593260(-) m6A CDS//exon       27773535//27773536
chr6:43593289-43593290(-) m6A CDS//exon       27773535//27773536
chr6:43593589-43593590(-) m6A CDS//exon       24209618//27773535//27371828//22575960
chr6:43593984-43593985(-) m6A CDS//exon       24284625//24209618//27773535//27371828//22575960
chr6:43594037-43594038(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960
chr6:43594671-43594672(-) m6A 5'UTR//CDS//exon       24284625//24209618//27773535
chr6:43596756-43596757(-) m6A CDS       25456834//24981863//27371828//27773536
chr6:43596769-43596770(-) m1A CDS       26863196//26863410
chr6:43596829-43596830(-) m6A CDS       25456834//24981863//27773535//27371828//27773536
chr6:43596885-43596886(-) Y CDS       26075521
chr6:43596894-43596895(-) m6A CDS       25456834//24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-5p
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
GTPBP2
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HeLa-S3 cells|K562 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)|K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-5p
Interactor2: GTPBP2

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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