Basic Information:

  VIRBase ID:  

HHID00004864

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          MTMR12:  NM_001294343     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	MTMR12
miRBase Accession/Entrez ID	MIMAT0000458	54545
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	3-PAP//PIP3AP

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MTMR12	chr5:32281188(-) A-I      intronic chr5:32281119(-) A-I      intronic chr5:32277723(-) A-I      intronic chr5:32277657(-) A-I      intronic chr5:32277552(-) A-I      intronic chr5:32277263(-) A-I      intronic chr5:32277181(-) A-I      intronic chr5:32277120(-) A-I      intronic chr5:32272731(-) A-I      intronic chr5:32244611(-) A-I      intronic chr5:32240815(-) A-I      intronic chr5:32240953(-) A-I      intronic chr5:32244530(-) A-I      intronic chr5:32244578(-) A-I      intronic chr5:32236647(-) A-I      intronic chr5:32237684(-) A-I      intronic chr5:32237685(-) A-I      intronic chr5:32244614(-) A-I      intronic chr5:32244615(-) A-I      intronic chr5:32244634(-) A-I      intronic chr5:32237714(-) A-I      intronic chr5:32237715(-) A-I      intronic chr5:32245928(-) A-I      intronic chr5:32245930(-) A-I      intronic chr5:32247456(-) A-I      intronic chr5:32253929(-) A-I      intronic chr5:32253930(-) A-I      intronic chr5:32253961(-) A-I      intronic chr5:32244694(-) A-I      intronic chr5:32245227(-) A-I      intronic chr5:32245231(-) A-I      intronic chr5:32245238(-) A-I      intronic chr5:32245253(-) A-I      intronic chr5:32245324(-) A-I      intronic chr5:32245330(-) A-I      intronic chr5:32245335(-) A-I      intronic chr5:32245350(-) A-I      intronic chr5:32245365(-) A-I      intronic chr5:32245865(-) A-I      intronic chr5:32245927(-) A-I      intronic chr5:32308914(-) A-I      intronic chr5:32308886(-) A-I      intronic chr5:32308881(-) A-I      intronic chr5:32236843(-) A-I      intronic chr5:32236831(-) A-I      intronic chr5:32236795(-) A-I      intronic chr5:32236794(-) A-I      intronic chr5:32236781(-) A-I      intronic chr5:32236772(-) A-I      intronic chr5:32254873(-) A-I      intronic chr5:32267382(-) A-I      intronic chr5:32267399(-) A-I      intronic chr5:32268012(-) A-I      intronic chr5:32268037(-) A-I      intronic chr5:32268531(-) A-I      intronic chr5:32268567(-) A-I      intronic chr5:32272239(-) A-I      intronic chr5:32272273(-) A-I      intronic chr5:32308352(-) A-I      intronic chr5:32308288(-) A-I      intronic chr5:32308265(-) A-I      intronic chr5:32308262(-) A-I      intronic chr5:32305970(-) A-I      intronic chr5:32272275(-) A-I      intronic chr5:32305963(-) A-I      intronic chr5:32305962(-) A-I      intronic chr5:32305949(-) A-I      intronic chr5:32305927(-) A-I      intronic chr5:32305926(-) A-I      intronic chr5:32305765(-) A-I      intronic chr5:32236787(-) A-I      intronic chr5:32305398(-) A-I      intronic chr5:32305271(-) A-I      intronic chr5:32296712(-) A-I      intronic chr5:32294615(-) A-I      intronic chr5:32294610(-) A-I      intronic chr5:32294546(-) A-I      intronic chr5:32285342(-) A-I      intronic chr5:32272522(-) A-I      intronic chr5:32272610(-) A-I      intronic chr5:32272664(-) A-I      intronic chr5:32272704(-) A-I      intronic chr5:32284398(-) A-I      intronic chr5:32238393(-) A-I      intronic chr5:32237749(-) A-I      intronic chr5:32237755(-) A-I      intronic chr5:32284388(-) A-I      intronic chr5:32238066(-) A-I      intronic chr5:32238083(-) A-I      intronic chr5:32238394(-) A-I      intronic chr5:32238346(-) A-I      intronic chr5:32238379(-) A-I      intronic chr5:32284377(-) A-I      intronic chr5:32284372(-) A-I      intronic chr5:32238395(-) A-I      intronic chr5:32238426(-) A-I      intronic chr5:32238586(-) A-I      intronic chr5:32281191(-) A-I      intronic chr5:32240342(-) A-I      intronic chr5:32240361(-) A-I      intronic chr5:32240466(-) A-I      intronic chr5:32228374(-) A-I      3'UTR chr5:32228744(-) A-I      3'UTR chr5:32228375(-) A-I      3'UTR chr5:32228755(-) A-I      3'UTR chr5:32228729(-) A-I      3'UTR chr5:32228742(-) A-I      3'UTR chr5:32245877(-) A-I      intronic chr5:32240774(-) A-I      intronic chr5:32308905(-) A-I      intronic chr5:32240845(-) A-I      intronic chr5:32294404(-) A-I      intronic chr5:32258211(-) A-I      intronic chr5:32240383(-) A-I      intronic chr5:32253976(-) A-I      intronic chr5:32236531(-) A-I      intronic chr5:32254005(-) A-I      intronic chr5:32305225(-) A-I      intronic chr5:32272662(-) A-I      intronic chr5:32272618(-) A-I      intronic chr5:32273340(-) A-I      intronic chr5:32286189(-) A-I      intronic chr5:32237974(-) A-I      intronic chr5:32272554(-) A-I      intronic chr5:32305427(-) A-I      intronic chr5:32294491(-) A-I      intronic chr5:32240244(-) A-I      intronic chr5:32285547(-) A-I      intronic chr5:32284302(-) A-I      intronic chr5:32238518(-) A-I      intronic chr5:32305359(-) A-I      intronic chr5:32238137(-) A-I      intronic chr5:32257712(-) A-I      intronic chr5:32268528(-) A-I      intronic chr5:32245794(-) A-I      intronic chr5:32240883(-) A-I      intronic chr5:32240980(-) A-I      intronic chr5:32236504(-) A-I      intronic chr5:32272334(-) A-I      intronic chr5:32245415(-) A-I      intronic chr5:32236617(-) A-I      intronic chr5:32285220(-) A-I      intronic chr5:32240835(-) A-I      intronic chr5:32245783(-) A-I      intronic chr5:32244493(-) A-I      intronic chr5:32228343(-) A-I      3'UTR chr5:32240250(-) A-I      intronic chr5:32277639(-) A-I      intronic chr5:32236619(-) A-I      intronic chr5:32285234(-) A-I      intronic chr5:32267396(-) A-I      intronic chr5:32267387(-) A-I      intronic chr5:32302666(-) A-I      intronic chr5:32245716(-) A-I      intronic chr5:32282292(-) A-I      intronic chr5:32238501(-) A-I      intronic chr5:32268104(-) A-I      intronic chr5:32305838(-) A-I      intronic chr5:32245771(-) A-I      intronic chr5:32305346(-) A-I      intronic chr5:32254911(-) A-I      intronic chr5:32236585(-) A-I      intronic chr5:32296003(-) A-I      intronic chr5:32277696(-) A-I      intronic chr5:32268521(-) A-I      intronic chr5:32296718(-) A-I      intronic chr5:32247264(-) A-I      intronic chr5:32238141(-) A-I      intronic chr5:32272667(-) A-I      intronic chr5:32240900(-) A-I      intronic chr5:32240979(-) A-I      intronic chr5:32277130(-) A-I      intronic chr5:32246433(-) A-I      intronic chr5:32272702(-) A-I      intronic chr5:32304314(-) A-I      intronic chr5:32238431(-) A-I      intronic chr5:32240775(-) A-I      intronic chr5:32272650(-) A-I      intronic chr5:32245852(-) A-I      intronic chr5:32240986(-) A-I      intronic chr5:32244696(-) A-I      intronic chr5:32277758(-) A-I      intronic chr5:32254867(-) A-I      intronic chr5:32244479(-) A-I      intronic chr5:32285551(-) A-I      intronic chr5:32264821(-) A-I      intronic chr5:32272701(-) A-I      intronic chr5:32240422(-) A-I      intronic chr5:32240885(-) A-I      intronic chr5:32308384(-) A-I      intronic chr5:32240325(-) A-I      intronic chr5:32300984(-) A-I      intronic chr5:32264731(-) A-I      intronic chr5:32284216(-) A-I      intronic chr5:32305280(-) A-I      intronic chr5:32238167(-) A-I      intronic chr5:32246448(-) A-I      intronic chr5:32240393(-) A-I      intronic chr5:32302674(-) A-I      intronic chr5:32254828(-) A-I      intronic chr5:32238138(-) A-I      intronic chr5:32236584(-) A-I      intronic chr5:32273391(-) A-I      intronic chr5:32311187(-) A-I      intronic chr5:32238168(-) A-I      intronic chr5:32308173(-) A-I      intronic chr5:32284296(-) A-I      intronic chr5:32277551(-) A-I      intronic chr5:32272757(-) A-I      intronic chr5:32236748(-) A-I      intronic chr5:32286183(-) A-I      intronic chr5:32267360(-) A-I      intronic chr5:32296405(-) A-I      intronic chr5:32301875(-) A-I      intronic chr5:32238522(-) A-I      intronic chr5:32294494(-) A-I      intronic chr5:32240405(-) A-I      intronic chr5:32246491(-) A-I      intronic chr5:32301775(-) A-I      intronic chr5:32311117(-) A-I      intronic chr5:32272153(-) A-I      intronic chr5:32245428(-) A-I      intronic chr5:32308346(-) A-I      intronic chr5:32277648(-) A-I      intronic chr5:32240889(-) A-I      intronic chr5:32308316(-) A-I      intronic chr5:32236487(-) A-I      intronic chr5:32272712(-) A-I      intronic chr5:32245822(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MTMR12	chr5:32228749(-) A-I exon 3'UTR    22327324 chr5:32240250(-) A-I intron -    22327324 chr5:32236584(-) A-G intron -    22484847 chr5:32236585(-) A-G intron -    22484847 chr5:32236617(-) A-G intron -    22484847 chr5:32236619(-) A-G intron -    22484847 chr5:32238137(-) A-G intron -    22484847 chr5:32238167(-) A-G intron -    22484847 chr5:32238198(-) A-G intron -    22484847 chr5:32238219(-) A-G intron -    22484847 chr5:32238431(-) A-G intron -    22484847 chr5:32240250(-) A-G intron -    22484847 chr5:32240262(-) A-G intron -    22484847 chr5:32240325(-) A-G intron -    22484847 chr5:32240775(-) A-G intron -    22484847 chr5:32240812(-) A-G intron -    22484847 chr5:32240835(-) A-G intron -    22484847 chr5:32240845(-) A-G intron -    22484847 chr5:32240886(-) A-G intron -    22484847 chr5:32240889(-) A-G intron -    22484847 chr5:32240979(-) A-G intron -    22484847 chr5:32240980(-) A-G intron -    22484847 chr5:32245428(-) A-G intron -    22484847 chr5:32245783(-) A-G intron -    22484847 chr5:32245794(-) A-G intron -    22484847 chr5:32245822(-) A-G intron -    22484847 chr5:32245852(-) A-G intron -    22484847 chr5:32245877(-) A-G intron -    22484847 chr5:32253736(-) G-A intron -    22484847 chr5:32254838(-) A-G intron -    22484847 chr5:32254867(-) A-G intron -    22484847 chr5:32254911(-) A-G intron -    22484847 chr5:32260143(-) G-T intron -    22484847 chr5:32267360(-) A-G intron -    22484847 chr5:32267387(-) A-G intron -    22484847 chr5:32267396(-) A-G intron -    22484847 chr5:32268104(-) A-G intron -    22484847 chr5:32268192(-) A-G intron -    22484847 chr5:32268196(-) A-G intron -    22484847 chr5:32268521(-) A-G intron -    22484847 chr5:32272624(-) A-G intron -    22484847 chr5:32272701(-) A-G intron -    22484847 chr5:32272702(-) A-G intron -    22484847 chr5:32272712(-) A-G intron -    22484847 chr5:32277639(-) A-G intron -    22484847 chr5:32277648(-) A-G intron -    22484847 chr5:32277656(-) A-G intron -    22484847 chr5:32277696(-) A-G intron -    22484847 chr5:32277697(-) A-G intron -    22484847 chr5:32277758(-) A-G intron -    22484847 chr5:32284216(-) A-G intron -    22484847 chr5:32285234(-) A-G intron -    22484847 chr5:32301875(-) A-G intron -    22484847 chr5:32305225(-) A-G intron -    22484847 chr5:32305263(-) A-G intron -    22484847 chr5:32305280(-) A-G intron -    22484847 chr5:32305319(-) A-G intron -    22484847 chr5:32305346(-) A-G intron -    22484847 chr5:32305838(-) A-G intron -    22484847 chr5:32305881(-) A-G intron -    22484847 chr5:32308316(-) A-G intron -    22484847 chr5:32308346(-) A-G intron -    22484847 chr5:32308384(-) A-G intron -    22484847 chr5:32308960(-) G-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MTMR12	chr5:32228317-32228318(-) m6A 3'UTR       24209618 chr5:32229274-32229275(-) m6A 3'UTR       24284625//27773535 chr5:32229295-32229296(-) m6A 3'UTR       24284625//27773535 chr5:32229339-32229340(-) m6A 3'UTR       27773535 chr5:32229380-32229381(-) m6A 3'UTR       27773535 chr5:32229694-32229695(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr5:32229708-32229709(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr5:32229762-32229763(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr5:32229838-32229839(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr5:32229899-32229900(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr5:32230034-32230035(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr5:32230084-32230085(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr5:32230138-32230139(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085 chr5:32230307-32230308(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:32230336-32230337(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:32230361-32230362(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:32230380-32230381(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:32234931-32234932(-) Am intron       16381836 chr5:32235156-32235157(-) m6A CDS//intron       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	MTMR12	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HeLa-S3 cells     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: MTMR12

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).