Basic Information:

  VIRBase ID:  

HHID00004846

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          BTBD1:  NM_025238     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	BTBD1
miRBase Accession/Entrez ID	MIMAT0000458	53339
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C15orf1//NS5ATP8

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	BTBD1	chr15:83710401(-) A-I      intronic chr15:83688971(-) A-I      intronic chr15:83685459(-) A-I      3'UTR chr15:83685527(-) A-I      3'UTR chr15:83685460(-) A-I      3'UTR chr15:83688207(-) A-I      intronic chr15:83688199(-) A-I      intronic chr15:83685458(-) A-I      3'UTR chr15:83688940(-) A-I      intronic chr15:83688475(-) A-I      intronic chr15:83724206(-) A-I      intronic chr15:83724182(-) A-I      intronic chr15:83685470(-) A-I      3'UTR chr15:83698458(-) A-I      intronic chr15:83711707(-) A-I      intronic chr15:83688458(-) A-I      intronic chr15:83724138(-) A-I      intronic chr15:83685487(-) A-I      3'UTR chr15:83688210(-) A-I      intronic chr15:83724213(-) A-I      intronic chr15:83724178(-) A-I      intronic chr15:83724181(-) A-I      intronic chr15:83688947(-) A-I      intronic chr15:83723399(-) A-I      intronic chr15:83722941(-) A-I      intronic chr15:83722921(-) A-I      intronic chr15:83721643(-) A-I      intronic chr15:83721554(-) A-I      intronic chr15:83721553(-) A-I      intronic chr15:83721547(-) A-I      intronic chr15:83721521(-) A-I      intronic chr15:83721515(-) A-I      intronic chr15:83721511(-) A-I      intronic chr15:83721494(-) A-I      intronic chr15:83721480(-) A-I      intronic chr15:83721468(-) A-I      intronic chr15:83721458(-) A-I      intronic chr15:83721418(-) A-I      intronic chr15:83711417(-) A-I      intronic chr15:83711337(-) A-I      intronic chr15:83711260(-) A-I      intronic chr15:83711241(-) A-I      intronic chr15:83711221(-) A-I      intronic chr15:83710272(-) A-I      intronic chr15:83710220(-) A-I      intronic chr15:83709828(-) A-I      intronic chr15:83709795(-) A-I      intronic chr15:83709782(-) A-I      intronic chr15:83709283(-) A-I      intronic chr15:83709270(-) A-I      intronic chr15:83703866(-) A-I      intronic chr15:83702462(-) A-I      intronic chr15:83696028(-) A-I      intronic chr15:83695976(-) A-I      intronic chr15:83695956(-) A-I      intronic chr15:83695941(-) A-I      intronic chr15:83695939(-) A-I      intronic chr15:83695922(-) A-I      intronic chr15:83694749(-) A-I      intronic chr15:83694717(-) A-I      intronic chr15:83694716(-) A-I      intronic chr15:83694702(-) A-I      intronic chr15:83694701(-) A-I      intronic chr15:83694692(-) A-I      intronic chr15:83694557(-) A-I      intronic chr15:83694071(-) A-I      intronic chr15:83693923(-) A-I      intronic chr15:83693889(-) A-I      intronic chr15:83693627(-) A-I      intronic chr15:83692801(-) A-I      intronic chr15:83692777(-) A-I      intronic chr15:83692393(-) A-I      intronic chr15:83692286(-) A-I      intronic chr15:83692280(-) A-I      intronic chr15:83691655(-) A-I      intronic chr15:83691637(-) A-I      intronic chr15:83691579(-) A-I      intronic chr15:83691565(-) A-I      intronic chr15:83691557(-) A-I      intronic chr15:83691531(-) A-I      intronic chr15:83691459(-) A-I      intronic chr15:83691313(-) A-I      intronic chr15:83691311(-) A-I      intronic chr15:83691301(-) A-I      intronic chr15:83691035(-) A-I      intronic chr15:83690828(-) A-I      intronic chr15:83690468(-) A-I      intronic chr15:83690394(-) A-I      intronic chr15:83690323(-) A-I      intronic chr15:83690314(-) A-I      intronic chr15:83690301(-) A-I      intronic chr15:83690289(-) A-I      intronic chr15:83689009(-) A-I      intronic chr15:83688937(-) A-I      intronic chr15:83688928(-) A-I      intronic chr15:83688923(-) A-I      intronic chr15:83688915(-) A-I      intronic chr15:83688911(-) A-I      intronic chr15:83688901(-) A-I      intronic chr15:83688479(-) A-I      intronic chr15:83688403(-) A-I      intronic chr15:83688110(-) A-I      intronic chr15:83688081(-) A-I      intronic chr15:83687972(-) A-I      intronic chr15:83687936(-) A-I      intronic chr15:83687900(-) A-I      intronic chr15:83691547(-) A-I      intronic chr15:83728625(-) A-I      intronic chr15:83728489(-) A-I      intronic chr15:83724837(-) A-I      intronic chr15:83724786(-) A-I      intronic chr15:83724773(-) A-I      intronic chr15:83724300(-) A-I      intronic chr15:83724174(-) A-I      intronic chr15:83724158(-) A-I      intronic chr15:83723527(-) A-I      intronic chr15:83723489(-) A-I      intronic chr15:83723484(-) A-I      intronic chr15:83723462(-) A-I      intronic chr15:83723452(-) A-I      intronic chr15:83723442(-) A-I      intronic chr15:83723438(-) A-I      intronic chr15:83723425(-) A-I      intronic chr15:83694726(-) A-I      intronic chr15:83691679(-) A-I      intronic chr15:83693603(-) A-I      intronic chr15:83723584(-) A-I      intronic chr15:83722834(-) A-I      intronic chr15:83688990(-) A-I      intronic chr15:83713986(-) A-I      intronic chr15:83702806(-) A-I      intronic chr15:83722888(-) A-I      intronic chr15:83724230(-) A-I      intronic chr15:83692357(-) A-I      intronic chr15:83690890(-) A-I      intronic chr15:83698539(-) A-I      intronic chr15:83723076(-) A-I      intronic chr15:83688426(-) A-I      intronic chr15:83690271(-) A-I      intronic chr15:83692850(-) A-I      intronic chr15:83724107(-) A-I      intronic chr15:83724147(-) A-I      intronic chr15:83690900(-) A-I      intronic chr15:83693604(-) A-I      intronic chr15:83692749(-) A-I      intronic chr15:83722978(-) A-I      intronic chr15:83693860(-) A-I      intronic chr15:83723585(-) A-I      intronic chr15:83692902(-) A-I      intronic chr15:83690430(-) A-I      intronic chr15:83692408(-) A-I      intronic chr15:83724210(-) A-I      intronic chr15:83722933(-) A-I      intronic chr15:83693427(-) A-I      intronic chr15:83709307(-) A-I      intronic chr15:83698406(-) A-I      intronic chr15:83691591(-) A-I      intronic chr15:83710204(-) A-I      intronic chr15:83711408(-) A-I      intronic chr15:83692896(-) A-I      intronic chr15:83711274(-) A-I      intronic chr15:83691542(-) A-I      intronic chr15:83710266(-) A-I      intronic chr15:83692802(-) A-I      intronic chr15:83709843(-) A-I      intronic chr15:83693943(-) A-I      intronic chr15:83722908(-) A-I      intronic chr15:83692772(-) A-I      intronic chr15:83696099(-) A-I      intronic chr15:83687950(-) A-I      intronic chr15:83687533(-) A-I      NonSyn:Thr->Ala chr15:83690935(-) A-I      intronic chr15:83703303(-) A-I      intronic chr15:83691241(-) A-I      intronic chr15:83692162(-) A-I      intronic chr15:83691089(-) A-I      intronic chr15:83690423(-) A-I      intronic chr15:83724876(-) A-I      intronic chr15:83722965(-) A-I      intronic chr15:83687940(-) A-I      intronic chr15:83688216(-) A-I      intronic chr15:83695451(-) A-I      intronic chr15:83722990(-) A-I      intronic chr15:83714249(-) A-I      intronic chr15:83693472(-) A-I      intronic chr15:83692223(-) A-I      intronic chr15:83723021(-) A-I      intronic chr15:83692256(-) A-I      intronic chr15:83720805(-) A-I      intronic chr15:83694589(-) A-I      intronic chr15:83694660(-) A-I      intronic chr15:83693495(-) A-I      intronic chr15:83710320(-) A-I      intronic chr15:83722942(-) A-I      intronic chr15:83688215(-) A-I      intronic chr15:83695492(-) A-I      intronic chr15:83724899(-) A-I      intronic chr15:83688907(-) A-I      intronic chr15:83695439(-) A-I      intronic chr15:83723008(-) A-I      intronic chr15:83698441(-) A-I      intronic chr15:83693994(-) A-I      intronic chr15:83721634(-) A-I      intronic chr15:83691001(-) A-I      intronic chr15:83691062(-) A-I      intronic chr15:83692788(-) A-I      intronic chr15:83709306(-) A-I      intronic chr15:83723007(-) A-I      intronic chr15:83728473(-) A-I      intronic chr15:83691372(-) A-I      intronic chr15:83728214(-) A-I      intronic chr15:83714004(-) A-I      intronic chr15:83691601(-) A-I      intronic chr15:83720794(-) A-I      intronic chr15:83709275(-) A-I      intronic chr15:83702478(-) A-I      intronic chr15:83691053(-) A-I      intronic chr15:83728619(-) A-I      intronic chr15:83724183(-) A-I      intronic chr15:83691630(-) A-I      intronic chr15:83709281(-) A-I      intronic chr15:83688484(-) A-I      intronic chr15:83711273(-) A-I      intronic chr15:83721025(-) A-I      intronic chr15:83708417(-) A-I      intronic chr15:83724148(-) A-I      intronic chr15:83693857(-) A-I      intronic chr15:83692717(-) A-I      intronic chr15:83728616(-) A-I      intronic chr15:83692735(-) A-I      intronic chr15:83721629(-) A-I      intronic chr15:83694047(-) A-I      intronic chr15:83723033(-) A-I      intronic chr15:83690339(-) A-I      intronic chr15:83721111(-) A-I      intronic chr15:83709389(-) A-I      intronic chr15:83723075(-) A-I      intronic chr15:83695380(-) A-I      intronic chr15:83694053(-) A-I      intronic chr15:83693984(-) A-I      intronic chr15:83688991(-) A-I      intronic chr15:83688218(-) A-I      intronic chr15:83709400(-) A-I      intronic chr15:83711409(-) A-I      intronic chr15:83710265(-) A-I      intronic chr15:83696004(-) A-I      intronic chr15:83693940(-) A-I      intronic chr15:83695982(-) A-I      intronic chr15:83691674(-) A-I      intronic chr15:83692421(-) A-I      intronic chr15:83692337(-) A-I      intronic chr15:83722925(-) A-I      intronic chr15:83728449(-) A-I      intronic chr15:83695900(-) A-I      intronic chr15:83710326(-) A-I      intronic chr15:83721412(-) A-I      intronic chr15:83711352(-) A-I      intronic chr15:83692759(-) A-I      intronic chr15:83695948(-) A-I      intronic chr15:83688485(-) A-I      intronic chr15:83692296(-) A-I      intronic chr15:83714149(-) A-I      intronic chr15:83692785(-) A-I      intronic chr15:83703169(-) A-I      intronic chr15:83722898(-) A-I      intronic chr15:83692895(-) A-I      intronic chr15:83691650(-) A-I      intronic chr15:83695992(-) A-I      intronic chr15:83709225(-) A-I      intronic chr15:83711228(-) A-I      intronic chr15:83701608(-) A-I      intronic chr15:83713988(-) A-I      intronic chr15:83721666(-) A-I      intronic chr15:83721056(-) A-I      intronic chr15:83728403(-) A-I      intronic chr15:83721593(-) A-I      intronic chr15:83701624(-) A-I      intronic chr15:83687879(-) A-I      intronic chr15:83720936(-) A-I      intronic chr15:83711726(-) A-I      intronic chr15:83693942(-) A-I      intronic chr15:83694816(-) A-I      intronic chr15:83710405(-) A-I      intronic chr15:83691481(-) A-I      intronic chr15:83728587(-) A-I      intronic chr15:83724242(-) A-I      intronic chr15:83723087(-) A-I      intronic chr15:83691337(-) A-I      intronic chr15:83688761(-) A-I      intronic chr15:83702572(-) A-I      intronic chr15:83692897(-) A-I      intronic chr15:83692224(-) A-I      intronic chr15:83711318(-) A-I      intronic chr15:83722968(-) A-I      intronic chr15:83710375(-) A-I      intronic chr15:83720782(-) A-I      intronic chr15:83703257(-) A-I      intronic chr15:83692695(-) A-I      intronic chr15:83710321(-) A-I      intronic chr15:83693643(-) A-I      intronic chr15:83691340(-) A-I      intronic chr15:83693481(-) A-I      intronic chr15:83709238(-) A-I      intronic chr15:83721648(-) A-I      intronic chr15:83721479(-) A-I      intronic chr15:83692804(-) A-I      intronic chr15:83710376(-) A-I      intronic chr15:83709818(-) A-I      intronic chr15:83688017(-) A-I      intronic chr15:83720833(-) A-I      intronic chr15:83710371(-) A-I      intronic chr15:83690422(-) A-I      intronic chr15:83711354(-) A-I      intronic chr15:83722958(-) A-I      intronic chr15:83709395(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	BTBD1	chr15:83687533(-) A-I exon CDS    19478186 chr15:83710320(-) A-I intron -    15258596 chr15:83710321(-) A-I intron -    15258596 chr15:83710326(-) A-I intron -    15258596 chr15:83690422(-) A-G intron -    22484847 chr15:83690423(-) A-G intron -    22484847 chr15:83692772(-) A-G intron -    22484847 chr15:83694660(-) A-G intron -    22484847 chr15:83695900(-) A-G intron -    22484847 chr15:83714918(-) G-A intron -    22484847 chr15:83720794(-) A-G intron -    22484847 chr15:83720805(-) A-G intron -    22484847 chr15:83722898(-) A-G intron -    22484847 chr15:83722908(-) A-G intron -    22484847 chr15:83723007(-) A-G intron -    22484847 chr15:83723008(-) A-G intron -    22484847 chr15:83723315(-) G-A intron -    22484847 chr15:83724148(-) A-G intron -    22484847 chr15:83724242(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	BTBD1	chr15:83685225-83685226(-) m6A 3'UTR       24981863 chr15:83685244-83685245(-) m6A 3'UTR       24981863 chr15:83685249-83685250(-) m6A 3'UTR       24981863 chr15:83685256-83685257(-) m6A 3'UTR       24981863 chr15:83685967-83685968(-) m6A 3'UTR       24284625//24981863//28052920//27773535//22608085 chr15:83686010-83686011(-) m6A 3'UTR       24284625//24981863//28052920//27773535//22608085 chr15:83686064-83686065(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr15:83686098-83686099(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr15:83686118-83686119(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr15:83686130-83686131(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr15:83686607-83686608(-) m6A 3'UTR       27773535 chr15:83686645-83686646(-) m6A 3'UTR       27773535 chr15:83686701-83686702(-) m6A 3'UTR       27773535 chr15:83686763-83686764(-) m6A 3'UTR       24981863//27773535//22608085 chr15:83686848-83686849(-) m6A 3'UTR//CDS       24284625//24981863//28052920//26404942//27773535//22608085 chr15:83686907-83686908(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085 chr15:83686925-83686926(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085 chr15:83687509-83687510(-) m6A 3'UTR//CDS       24284625 chr15:83699006-83699007(-) m6A 3'UTR//CDS//exon       27773535 chr15:83699037-83699038(-) m6A 3'UTR//CDS//exon       27773535 chr15:83710549-83710550(-) m6A 3'UTR//CDS//exon       24981863 chr15:83710579-83710580(-) m6A 3'UTR//CDS       24981863 chr15:83735774-83735775(-) m6A CDS       24209618//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	BTBD1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: BTBD1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).