Basic Information:

  VIRBase ID:  

HHID00004826

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          HOOK1:  NM_015888     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	HOOK1
miRBase Accession/Entrez ID	MIMAT0000458	51361
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HK1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	HOOK1	chr1:60322075(+) A-I      intronic chr1:60322080(+) A-I      intronic chr1:60320517(+) A-I      intronic chr1:60296782(+) A-I      intronic chr1:60322078(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	HOOK1	chr1:60320517(+) A-G intron -    22484847 chr1:60322078(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	HOOK1	chr1:60314173-60314174(+) m6A CDS//exon       24981863 chr1:60314764-60314765(+) m6A CDS//exon       24981863 chr1:60314790-60314791(+) m6A CDS//exon       24981863 chr1:60314827-60314828(+) m6A CDS//exon       24981863 chr1:60324101-60324102(+) m6A CDS//exon       24981863 chr1:60328521-60328522(+) m6A CDS//exon       24981863 chr1:60330804-60330805(+) m6A exon//intron       24981863 chr1:60330840-60330841(+) m6A CDS//exon//intron       24981863 chr1:60330873-60330874(+) m6A CDS//exon//intron       24981863//27773535 chr1:60330879-60330880(+) m6A CDS//exon//intron       24981863//27773535 chr1:60331559-60331560(+) m6A CDS//exon       24981863//27773535//22608085 chr1:60333930-60333931(+) m6A CDS//exon       24981863//22608085 chr1:60338637-60338638(+) m6A 3'UTR//exon       24981863 chr1:60338649-60338650(+) m6A 3'UTR//exon       24981863 chr1:60338654-60338655(+) m6A 3'UTR//exon       24981863 chr1:60338659-60338660(+) m6A 3'UTR//exon       24981863 chr1:60338667-60338668(+) m6A 3'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	HOOK1	Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: HOOK1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).