Basic Information:

  VIRBase ID:  

HHID00004787

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          HCFC2:  NM_013320     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	HCFC2
miRBase Accession/Entrez ID	MIMAT0000458	29915
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HCF-2//HCF2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	HCFC2	chr12:104471978(+) A-I      intronic chr12:104471986(+) A-I      intronic chr12:104466629(+) A-I      intronic chr12:104493709(+) A-I      intronic chr12:104493583(+) A-I      intronic chr12:104468855(+) A-I      intronic chr12:104465435(+) A-I      intronic chr12:104493353(+) A-I      intronic chr12:104471926(+) A-I      intronic chr12:104493258(+) A-I      intronic chr12:104468877(+) A-I      intronic chr12:104465388(+) A-I      intronic chr12:104493236(+) A-I      intronic chr12:104493370(+) A-I      intronic chr12:104493644(+) A-I      intronic chr12:104477681(+) A-I      intronic chr12:104493635(+) A-I      intronic chr12:104493632(+) A-I      intronic chr12:104477679(+) A-I      intronic chr12:104494081(+) A-I      intronic chr12:104465896(+) A-I      intronic chr12:104465895(+) A-I      intronic chr12:104494286(+) A-I      intronic chr12:104471919(+) A-I      intronic chr12:104468904(+) A-I      intronic chr12:104493250(+) A-I      intronic chr12:104467970(+) A-I      intronic chr12:104493467(+) A-I      intronic chr12:104493618(+) A-I      intronic chr12:104494120(+) A-I      intronic chr12:104494161(+) A-I      intronic chr12:104493377(+) A-I      intronic chr12:104465429(+) A-I      intronic chr12:104477708(+) A-I      intronic chr12:104494087(+) A-I      intronic chr12:104495112(+) A-I      intronic chr12:104466684(+) A-I      intronic chr12:104493488(+) A-I      intronic chr12:104465995(+) A-I      intronic chr12:104465946(+) A-I      intronic chr12:104468875(+) A-I      intronic chr12:104466099(+) A-I      intronic chr12:104493655(+) A-I      intronic chr12:104466089(+) A-I      intronic chr12:104494998(+) A-I      intronic chr12:104469370(+) A-I      intronic chr12:104465389(+) A-I      intronic chr12:104493548(+) A-I      intronic chr12:104493518(+) A-I      intronic chr12:104464604(+) A-I      intronic chr12:104479869(+) A-I      intronic chr12:104477622(+) A-I      intronic chr12:104494126(+) A-I      intronic chr12:104494147(+) A-I      intronic chr12:104477655(+) A-I      intronic chr12:104467203(+) A-I      intronic chr12:104463004(+) A-I      intronic chr12:104471972(+) A-I      intronic chr12:104493523(+) A-I      intronic chr12:104466013(+) A-I      intronic chr12:104493577(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	HCFC2	chr12:104493577(+) A-I intron -    22327324 chr12:104493583(+) A-I intron -    22327324 chr12:104493518(+) A-G intron -    22484847 chr12:104493577(+) A-G intron -    22484847 chr12:104493583(+) A-G intron -    22484847 chr12:104465388(+) A-G intron -    22484847 chr12:104465435(+) A-G intron -    22484847 chr12:104465946(+) A-G intron -    22484847 chr12:104468875(+) A-G intron -    22484847 chr12:104493250(+) A-G intron -    22484847 chr12:104493655(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	HCFC2	chr12:104458412-104458413(+) m6A CDS       - chr12:104496765-104496766(+) m6A 3'UTR//CDS//exon       24284625//22608085 chr12:104496886-104496887(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr12:104496993-104496994(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr12:104497160-104497161(+) m6A 3'UTR//exon       24981863 chr12:104497232-104497233(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	HCFC2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: HCFC2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).