Detail Information

Basic Information:


  VIRBase ID:  

HHID00004786

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:           CNOT7:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-5p CNOT7
miRBase
Accession/Entrez ID		 MIMAT0000458 29883
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CAF-1//CAF1//Caf1a//hCAF-1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-5p
rs1018706777 chr15:62823984    A/G
rs1369926402 chr15:62823991    G/A
rs1555521311 chr15:62823990    G/C
rs755866868 chr15:62823986    A/G
rs766742872 chr15:62823990    GGTT/G
rs777464613 chr15:62823987    T/G
rs1228899174 chr15:62823974    T/A
rs1281303771 chr15:62823976    T/C
rs1350000299 chr15:62823972    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CNOT7
chr8:17097863(-) A-I      intronic
chr8:17098530(-) A-I      intronic
chr8:17098502(-) A-I      intronic
chr8:17098490(-) A-I      intronic
chr8:17097842(-) A-I      intronic
chr8:17097837(-) A-I      intronic
chr8:17097833(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CNOT7
chr8:17097835(-) A-I intron -    22327324
chr8:17098438(-) A-I intron -    22327324
chr8:17098483(-) A-I intron -    22327324
chr8:17098519(-) A-I intron -    22327324
chr8:17097835(-) A-G intron -    22484847
chr8:17097963(-) A-G intron -    22484847
chr8:17098400(-) A-G intron -    22484847
chr8:17098438(-) A-G intron -    22484847
chr8:17098483(-) A-G intron -    22484847
chr8:17098484(-) A-G intron -    22484847
chr8:17098519(-) A-G intron -    22484847
chr8:17097253(-) G-A intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CNOT7
chr8:17086958-17086959(-) m6A 3'UTR       24981863
chr8:17086996-17086997(-) m6A 3'UTR       24981863
chr8:17087016-17087017(-) m6A 3'UTR       24981863
chr8:17087053-17087054(-) m6A 3'UTR       24981863
chr8:17089887-17089888(-) m6A 3'UTR//intron       24981863
chr8:17089926-17089927(-) m6A 3'UTR//intron       24981863
chr8:17094818-17094819(-) m6A 3'UTR//CDS//exon       27773535
chr8:17094861-17094862(-) m6A 3'UTR//CDS//exon       27773535
chr8:17094876-17094877(-) m6A 3'UTR//CDS//exon       27773535
chr8:17094938-17094939(-) m6A exon//intron       27773535
chr8:17094996-17094997(-) m6A exon//intron       27773535
chr8:17095004-17095005(-) m6A exon//intron       27773535
chr8:17100261-17100262(-) m6A exon//intron       27773535
chr8:17100537-17100538(-) m6A 3'UTR//CDS//exon       24284625//22608085
chr8:17100577-17100578(-) m6A 3'UTR//CDS//exon       24284625//22608085
chr8:17100602-17100603(-) m6A 3'UTR//CDS//exon       24284625//22608085
chr8:17100664-17100665(-) m6A 3'UTR//CDS//exon       24284625//22608085
chr8:17104107-17104108(-) m6A 5'UTR//intron       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-5p
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
CNOT7
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-5p
Interactor2: CNOT7

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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