Basic Information:

  VIRBase ID:  

HHID00004761

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          INTU:  NM_015693     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	INTU
miRBase Accession/Entrez ID	MIMAT0000458	27152
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CPLANE4//INT//OFD17//PDZD6//PDZK6//SRTD20

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	INTU	chr4:128580285(+) A-I      intronic chr4:128580284(+) A-I      intronic chr4:128580257(+) A-I      intronic chr4:128580286(+) A-I      intronic chr4:128580282(+) A-I      intronic chr4:128580260(+) A-I      intronic chr4:128580252(+) A-I      intronic chr4:128580245(+) A-I      intronic chr4:128580219(+) A-I      intronic chr4:128580218(+) A-I      intronic chr4:128610693(+) A-I      intronic chr4:128625631(+) A-I      intronic chr4:128625981(+) A-I      intronic chr4:128625622(+) A-I      intronic chr4:128625678(+) A-I      intronic chr4:128619155(+) A-I      intronic chr4:128610374(+) A-I      intronic chr4:128610590(+) A-I      intronic chr4:128610322(+) A-I      intronic chr4:128610377(+) A-I      intronic chr4:128610596(+) A-I      intronic chr4:128610814(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	INTU	chr4:128544511-128544512(+) m6A 5'UTR       25456834 chr4:128544589-128544590(+) m6A CDS       24209618//25456834//22608085 chr4:128544612-128544613(+) m6A CDS       24209618//25456834//22608085 chr4:128544618-128544619(+) m6A CDS       24209618//25456834//22608085 chr4:128564698-128564699(+) m6A CDS       22608085 chr4:128564772-128564773(+) m6A CDS       27773535//22608085 chr4:128564785-128564786(+) m6A CDS       24981863//27773535//22608085 chr4:128564852-128564853(+) m6A CDS       24284625//24981863//27773535//22608085 chr4:128564858-128564859(+) m6A CDS       24284625//24981863//27773535//22608085 chr4:128564894-128564895(+) m6A CDS       24284625//24981863//27773535//22608085 chr4:128564939-128564940(+) m6A CDS       24284625//24981863//27773535//22608085 chr4:128564976-128564977(+) m6A CDS       24284625//24981863//27773535//22608085 chr4:128565025-128565026(+) m6A CDS       24981863//27773535//22608085 chr4:128565102-128565103(+) m6A CDS       24981863//22608085 chr4:128565123-128565124(+) m6A CDS       22608085 chr4:128627643-128627644(+) m6A 3'UTR//CDS//exon       22608085 chr4:128627709-128627710(+) m6A 3'UTR//CDS       24981863//22608085 chr4:128627714-128627715(+) m6A 3'UTR//CDS       24981863//22608085 chr4:128627740-128627741(+) m6A 3'UTR//CDS       24981863//22608085 chr4:128627854-128627855(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr4:128627962-128627963(+) m6A 3'UTR//CDS       24981863//22608085 chr4:128628112-128628113(+) m6A 3'UTR//CDS       22608085 chr4:128635164-128635165(+) m6A 3'UTR//CDS       22608085 chr4:128635196-128635197(+) m6A 3'UTR//CDS       22608085 chr4:128635201-128635202(+) m6A 3'UTR//CDS       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	INTU	Exosome Blood     - Nucleolus K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: INTU

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).