Basic Information:

  VIRBase ID:  

HHID00004741

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          SENP3:  NM_015670     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	SENP3
miRBase Accession/Entrez ID	MIMAT0000458	26168
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	SMT3IP1//SSP3//Ulp1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SENP3	chr17:7470769(+) A-I      intronic chr17:7470765(+) A-I      intronic chr17:7469904(+) A-I      intronic chr17:7472605(+) A-I      intronic chr17:7472582(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SENP3	chr17:7465195-7465196(+) m6A 5'UTR       24981863 chr17:7465474-7465475(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960 chr17:7466402-7466403(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr17:7466414-7466415(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr17:7466443-7466444(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr17:7466509-7466510(+) m6A CDS       24284625//24209618//24981863//22575960 chr17:7466558-7466559(+) m6A CDS       24284625//24209618//24981863//22575960 chr17:7466631-7466632(+) m1A CDS       26863196//26863410 chr17:7466711-7466712(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr17:7466753-7466754(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr17:7466889-7466890(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr17:7467067-7467068(+) m6A CDS       24284625//25456834//24981863//22575960 chr17:7467077-7467078(+) m6A CDS       24284625//25456834//24981863//22575960 chr17:7467096-7467097(+) m6A CDS       24284625//25456834//22575960 chr17:7467731-7467732(+) m6A exon//intron       24284625 chr17:7467762-7467763(+) m6A exon//intron       24284625 chr17:7467978-7467979(+) m6A CDS//exon       24284625//22575960 chr17:7468058-7468059(+) m6A CDS//exon       24284625//22575960 chr17:7474739-7474740(+) m6A 3'UTR//CDS//exon       - chr17:7474749-7474750(+) m6A 3'UTR//CDS//exon       - chr17:7474788-7474789(+) m6A CDS//exon       - chr17:7474815-7474816(+) m6A 3'UTR//exon//intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	SENP3	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: SENP3

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).