Basic Information:

  VIRBase ID:  

HHID00004718

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          SLC24A2:  NM_001193288     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	SLC24A2
miRBase Accession/Entrez ID	MIMAT0000458	25769
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	NCKX2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SLC24A2	chr9:19557915(-) A-I      intronic chr9:19557946(-) A-I      intronic chr9:19561147(-) A-I      intronic chr9:19548546(-) A-I      intronic chr9:19548539(-) A-I      intronic chr9:19548534(-) A-I      intronic chr9:19548532(-) A-I      intronic chr9:19548531(-) A-I      intronic chr9:19548506(-) A-I      intronic chr9:19760455(-) A-I      intronic chr9:19760454(-) A-I      intronic chr9:19760426(-) A-I      intronic chr9:19760425(-) A-I      intronic chr9:19760421(-) A-I      intronic chr9:19523059(-) A-I      intronic chr9:19561056(-) A-I      intronic chr9:19561061(-) A-I      intronic chr9:19557933(-) A-I      intronic chr9:19562873(-) A-I      intronic chr9:19564016(-) A-I      intronic chr9:19561662(-) A-I      intronic chr9:19563068(-) A-I      intronic chr9:19523097(-) A-I      intronic chr9:19555880(-) A-I      intronic chr9:19562899(-) A-I      intronic chr9:19558087(-) A-I      intronic chr9:19523142(-) A-I      intronic chr9:19523112(-) A-I      intronic chr9:19508525(-) A-I      3'UTR chr9:19665652(-) A-I      intronic chr9:19780640(-) A-I      intronic chr9:19563009(-) A-I      intronic chr9:19612429(-) A-I      intronic chr9:19780809(-) A-I      intronic chr9:19557998(-) A-I      intronic chr9:19612844(-) A-I      intronic chr9:19612377(-) A-I      intronic chr9:19780789(-) A-I      intronic chr9:19780351(-) A-I      intronic chr9:19780649(-) A-I      intronic chr9:19779801(-) A-I      intronic chr9:19522123(-) A-I      intronic chr9:19572175(-) A-I      intronic chr9:19612450(-) A-I      intronic chr9:19562933(-) A-I      intronic chr9:19780824(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SLC24A2	chr9:19512352-19512353(-) m6A 3'UTR       25456834 chr9:19512438-19512439(-) m6A 3'UTR       25456834 chr9:19512477-19512478(-) m6A 3'UTR       25456834 chr9:19514184-19514185(-) m6A 3'UTR       25456834 chr9:19514252-19514253(-) m6A 3'UTR       25456834 chr9:19514264-19514265(-) m6A 3'UTR       25456834 chr9:19515847-19515848(-) m6A 3'UTR       24981863//22575960 chr9:19515853-19515854(-) m6A 3'UTR       24981863//22575960 chr9:19515927-19515928(-) m6A 3'UTR       25456834//24981863//22575960 chr9:19515936-19515937(-) m6A 3'UTR       25456834//24981863//22575960 chr9:19786300-19786301(-) m6A CDS       25456834//22575960 chr9:19786363-19786364(-) m6A CDS       25456834//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	SLC24A2	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: SLC24A2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).