Basic Information:

  VIRBase ID:  

HHID00004716

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          OSBP2:  NM_001282740     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	OSBP2
miRBase Accession/Entrez ID	MIMAT0000458	23762
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HLM//ORP-4//ORP4//OSBPL1//OSBPL4

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	OSBP2	chr22:31183271(+) A-I      intronic chr22:31183328(+) A-I      intronic chr22:31292799(+) A-I      intronic chr22:31292762(+) A-I      intronic chr22:31292759(+) A-I      intronic chr22:31292722(+) A-I      intronic chr22:31297691(+) A-I      intronic chr22:31214095(+) A-I      intronic chr22:31271621(+) A-I      intronic chr22:31271620(+) A-I      intronic chr22:31271597(+) A-I      intronic chr22:31301003(+) A-I      intronic chr22:31297702(+) A-I      intronic chr22:31297701(+) A-I      intronic chr22:31297696(+) A-I      intronic chr22:31297694(+) A-I      intronic chr22:31297676(+) A-I      intronic chr22:31297276(+) A-I      intronic chr22:31099563(+) A-I      intronic chr22:31097034(+) A-I      intronic chr22:31296070(+) A-I      intronic chr22:31134572(+) A-I      intronic chr22:31295999(+) A-I      intronic chr22:31295342(+) A-I      intronic chr22:31295322(+) A-I      intronic chr22:31295318(+) A-I      intronic chr22:31295299(+) A-I      intronic chr22:31295278(+) A-I      intronic chr22:31295272(+) A-I      intronic chr22:31295266(+) A-I      intronic chr22:31295134(+) A-I      intronic chr22:31295096(+) A-I      intronic chr22:31292778(+) A-I      intronic chr22:31292714(+) A-I      intronic chr22:31190449(+) A-I      intronic chr22:31190441(+) A-I      intronic chr22:31188169(+) A-I      intronic chr22:31181536(+) A-I      intronic chr22:31180493(+) A-I      intronic chr22:31176538(+) A-I      intronic chr22:31169143(+) A-I      intronic chr22:31165407(+) A-I      intronic chr22:31296196(+) A-I      intronic chr22:31164406(+) A-I      intronic chr22:31156010(+) A-I      intronic chr22:31155206(+) A-I      intronic chr22:31155149(+) A-I      intronic chr22:31155148(+) A-I      intronic chr22:31148415(+) A-I      intronic chr22:31145800(+) A-I      intronic chr22:31144951(+) A-I      intronic chr22:31144021(+) A-I      intronic chr22:31142360(+) A-I      intronic chr22:31296206(+) A-I      intronic chr22:31296220(+) A-I      intronic chr22:31297197(+) A-I      intronic chr22:31297211(+) A-I      intronic chr22:31297239(+) A-I      intronic chr22:31142280(+) A-I      intronic chr22:31142277(+) A-I      intronic chr22:31142275(+) A-I      intronic chr22:31297801(+) A-I      intronic chr22:31300898(+) A-I      intronic chr22:31296031(+) A-I      intronic chr22:31142268(+) A-I      intronic chr22:31297618(+) A-I      intronic chr22:31297619(+) A-I      intronic chr22:31297637(+) A-I      intronic chr22:31141543(+) A-I      intronic chr22:31141520(+) A-I      intronic chr22:31141511(+) A-I      intronic chr22:31300913(+) A-I      intronic chr22:31141507(+) A-I      intronic chr22:31131136(+) A-I      intronic chr22:31131018(+) A-I      intronic chr22:31130976(+) A-I      intronic chr22:31130061(+) A-I      intronic chr22:31300939(+) A-I      intronic chr22:31126116(+) A-I      intronic chr22:31126115(+) A-I      intronic chr22:31126079(+) A-I      intronic chr22:31297666(+) A-I      intronic chr22:31124625(+) A-I      intronic chr22:31297709(+) A-I      intronic chr22:31101463(+) A-I      intronic chr22:31101384(+) A-I      intronic chr22:31297222(+) A-I      intronic chr22:31301403(+) A-I      intronic chr22:31126164(+) A-I      intronic chr22:31144947(+) A-I      intronic chr22:31133577(+) A-I      intronic chr22:31296126(+) A-I      intronic chr22:31183501(+) A-I      intronic chr22:31291814(+) A-I      intronic chr22:31120897(+) A-I      intronic chr22:31296175(+) A-I      intronic chr22:31145038(+) A-I      intronic chr22:31182992(+) A-I      intronic chr22:31124719(+) A-I      intronic chr22:31211195(+) A-I      intronic chr22:31292735(+) A-I      intronic chr22:31099567(+) A-I      intronic chr22:31233269(+) A-I      intronic chr22:31292187(+) A-I      intronic chr22:31301246(+) A-I      intronic chr22:31143354(+) A-I      intronic chr22:31297642(+) A-I      intronic chr22:31133516(+) A-I      intronic chr22:31130197(+) A-I      intronic chr22:31204393(+) A-I      intronic chr22:31105706(+) A-I      intronic chr22:31291778(+) A-I      intronic chr22:31107576(+) A-I      intronic chr22:31216213(+) A-I      intronic chr22:31301233(+) A-I      intronic chr22:31301381(+) A-I      intronic chr22:31156253(+) A-I      intronic chr22:31292766(+) A-I      intronic chr22:31291698(+) A-I      intronic chr22:31295358(+) A-I      intronic chr22:31121375(+) A-I      intronic chr22:31265635(+) A-I      intronic chr22:31295313(+) A-I      intronic chr22:31292772(+) A-I      intronic chr22:31145830(+) A-I      intronic chr22:31124601(+) A-I      intronic chr22:31292190(+) A-I      intronic chr22:31145869(+) A-I      intronic chr22:31115661(+) A-I      intronic chr22:31099566(+) A-I      intronic chr22:31096011(+) A-I      intronic chr22:31189524(+) A-I      intronic chr22:31115581(+) A-I      intronic chr22:31183495(+) A-I      intronic chr22:31292686(+) A-I      intronic chr22:31121075(+) A-I      intronic chr22:31301278(+) A-I      intronic chr22:31295166(+) A-I      intronic chr22:31175169(+) A-I      intronic chr22:31187443(+) A-I      intronic chr22:31125738(+) A-I      intronic chr22:31171913(+) A-I      intronic chr22:31297185(+) A-I      intronic chr22:31300937(+) A-I      intronic chr22:31297120(+) A-I      intronic chr22:31187575(+) A-I      intronic chr22:31121304(+) A-I      intronic chr22:31301213(+) A-I      intronic chr22:31132042(+) A-I      intronic chr22:31107659(+) A-I      intronic chr22:31105620(+) A-I      intronic chr22:31174006(+) A-I      intronic chr22:31297665(+) A-I      intronic chr22:31140637(+) A-I      intronic chr22:31296121(+) A-I      intronic chr22:31142352(+) A-I      intronic chr22:31295385(+) A-I      intronic chr22:31145675(+) A-I      intronic chr22:31144966(+) A-I      intronic chr22:31301405(+) A-I      intronic chr22:31103975(+) A-I      intronic chr22:31099737(+) A-I      intronic chr22:31096886(+) A-I      intronic chr22:31130987(+) A-I      intronic chr22:31291671(+) A-I      intronic chr22:31295282(+) A-I      intronic chr22:31297265(+) A-I      intronic chr22:31297630(+) A-I      intronic chr22:31194840(+) A-I      intronic chr22:31174751(+) A-I      intronic chr22:31190768(+) A-I      intronic chr22:31142337(+) A-I      intronic chr22:31120334(+) A-I      intronic chr22:31098571(+) A-I      intronic chr22:31293833(+) A-I      intronic chr22:31120344(+) A-I      intronic chr22:31131994(+) A-I      intronic chr22:31291840(+) A-I      intronic chr22:31156080(+) A-I      intronic chr22:31110660(+) A-I      intronic chr22:31111791(+) A-I      intronic chr22:31107620(+) A-I      intronic chr22:31131099(+) A-I      intronic chr22:31301251(+) A-I      intronic chr22:31130920(+) A-I      intronic chr22:31301317(+) A-I      intronic chr22:31124609(+) A-I      intronic chr22:31292704(+) A-I      intronic chr22:31162195(+) A-I      intronic chr22:31124514(+) A-I      intronic chr22:31301316(+) A-I      intronic chr22:31291670(+) A-I      intronic chr22:31270117(+) A-I      intronic chr22:31297109(+) A-I      intronic chr22:31096051(+) A-I      intronic chr22:31111727(+) A-I      intronic chr22:31297330(+) A-I      intronic chr22:31121950(+) A-I      intronic chr22:31134749(+) A-I      intronic chr22:31216105(+) A-I      intronic chr22:31128019(+) A-I      intronic chr22:31131981(+) A-I      intronic chr22:31291804(+) A-I      intronic chr22:31107612(+) A-I      intronic chr22:31121947(+) A-I      intronic chr22:31237869(+) A-I      intronic chr22:31178449(+) A-I      intronic chr22:31142305(+) A-I      intronic chr22:31124013(+) A-I      intronic chr22:31124668(+) A-I      intronic chr22:31203962(+) A-I      intronic chr22:31301065(+) A-I      intronic chr22:31292824(+) A-I      intronic chr22:31158164(+) A-I      intronic chr22:31111724(+) A-I      intronic chr22:31178388(+) A-I      intronic chr22:31095122(+) A-I      intronic chr22:31291749(+) A-I      intronic chr22:31124537(+) A-I      intronic chr22:31301328(+) A-I      intronic chr22:31250451(+) A-I      intronic chr22:31292887(+) A-I      intronic chr22:31190369(+) A-I      intronic chr22:31189539(+) A-I      intronic chr22:31293887(+) A-I      intronic chr22:31171833(+) A-I      intronic chr22:31137813(+) A-I      intronic chr22:31294328(+) A-I      intronic chr22:31124649(+) A-I      intronic chr22:31142142(+) A-I      intronic chr22:31156094(+) A-I      intronic chr22:31096173(+) A-I      intronic chr22:31183404(+) A-I      intronic chr22:31297731(+) A-I      intronic chr22:31105729(+) A-I      intronic chr22:31126995(+) A-I      intronic chr22:31174767(+) A-I      intronic chr22:31295374(+) A-I      intronic chr22:31292281(+) A-I      intronic chr22:31105589(+) A-I      intronic chr22:31126933(+) A-I      intronic chr22:31096212(+) A-I      intronic chr22:31297155(+) A-I      intronic chr22:31292191(+) A-I      intronic chr22:31300859(+) A-I      intronic chr22:31124712(+) A-I      intronic chr22:31131068(+) A-I      intronic chr22:31297075(+) A-I      intronic chr22:31178088(+) A-I      intronic chr22:31096222(+) A-I      intronic chr22:31292760(+) A-I      intronic chr22:31188108(+) A-I      intronic chr22:31104993(+) A-I      intronic chr22:31291818(+) A-I      intronic chr22:31144893(+) A-I      intronic chr22:31216206(+) A-I      intronic chr22:31107676(+) A-I      intronic chr22:31124532(+) A-I      intronic chr22:31176624(+) A-I      intronic chr22:31293816(+) A-I      intronic chr22:31297705(+) A-I      intronic chr22:31145607(+) A-I      intronic chr22:31131064(+) A-I      intronic chr22:31291677(+) A-I      intronic chr22:31104615(+) A-I      intronic chr22:31295262(+) A-I      intronic chr22:31293817(+) A-I      intronic chr22:31297773(+) A-I      intronic chr22:31152592(+) A-I      intronic chr22:31293844(+) A-I      intronic chr22:31240136(+) A-I      intronic chr22:31175350(+) A-I      intronic chr22:31231733(+) A-I      intronic chr22:31300978(+) A-I      intronic chr22:31096939(+) A-I      intronic chr22:31158087(+) A-I      intronic chr22:31296007(+) A-I      intronic chr22:31301314(+) A-I      intronic chr22:31104743(+) A-I      intronic chr22:31225569(+) A-I      intronic chr22:31231979(+) A-I      intronic chr22:31163230(+) A-I      intronic chr22:31204012(+) A-I      intronic chr22:31216112(+) A-I      intronic chr22:31294232(+) A-I      intronic chr22:31301045(+) A-I      intronic chr22:31291725(+) A-I      intronic chr22:31121867(+) A-I      intronic chr22:31297087(+) A-I      intronic chr22:31241266(+) A-I      intronic chr22:31105637(+) A-I      intronic chr22:31295982(+) A-I      intronic chr22:31132081(+) A-I      intronic chr22:31115662(+) A-I      intronic chr22:31144332(+) A-I      intronic chr22:31300868(+) A-I      intronic chr22:31301197(+) A-I      intronic chr22:31190386(+) A-I      intronic chr22:31183563(+) A-I      intronic chr22:31301013(+) A-I      intronic chr22:31174031(+) A-I      intronic chr22:31292818(+) A-I      intronic chr22:31122019(+) A-I      intronic chr22:31301030(+) A-I      intronic chr22:31103905(+) A-I      intronic chr22:31215199(+) A-I      intronic chr22:31156574(+) A-I      intronic chr22:31132030(+) A-I      intronic chr22:31292816(+) A-I      intronic chr22:31270136(+) A-I      intronic chr22:31192747(+) A-I      intronic chr22:31292658(+) A-I      intronic chr22:31158138(+) A-I      intronic chr22:31204686(+) A-I      intronic chr22:31121401(+) A-I      intronic chr22:31163209(+) A-I      intronic chr22:31115621(+) A-I      intronic chr22:31141534(+) A-I      intronic chr22:31292870(+) A-I      intronic chr22:31183575(+) A-I      intronic chr22:31180334(+) A-I      intronic chr22:31300921(+) A-I      intronic chr22:31143375(+) A-I      intronic chr22:31292154(+) A-I      intronic chr22:31123971(+) A-I      intronic chr22:31295348(+) A-I      intronic chr22:31297195(+) A-I      intronic chr22:31189627(+) A-I      intronic chr22:31295303(+) A-I      intronic chr22:31188097(+) A-I      intronic chr22:31291740(+) A-I      intronic chr22:31144969(+) A-I      intronic chr22:31111380(+) A-I      intronic chr22:31121860(+) A-I      intronic chr22:31115630(+) A-I      intronic chr22:31097411(+) A-I      intronic chr22:31301025(+) A-I      intronic chr22:31172051(+) A-I      intronic chr22:31126130(+) A-I      intronic chr22:31295295(+) A-I      intronic chr22:31297732(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	OSBP2	chr22:31297731(+) A-I intron -    15258596 chr22:31297732(+) A-I intron -    15258596 chr22:31297762(+) A-I intron -    15258596

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	OSBP2	chr22:31091072-31091073(+) m6A CDS//intron       - chr22:31091084-31091085(+) m6A CDS//intron       - chr22:31091096-31091097(+) m6A CDS//intron       - chr22:31091138-31091139(+) m6A CDS//intron       - chr22:31091192-31091193(+) m6A CDS//intron       - chr22:31091363-31091364(+) m6A CDS//intron       - chr22:31091373-31091374(+) m6A CDS//intron       - chr22:31137284-31137285(+) m6A 5'UTR//CDS       - chr22:31137344-31137345(+) m6A CDS       - chr22:31199131-31199132(+) m6A 5'UTR//intron       24284625//24981863 chr22:31218566-31218567(+) m6A 5'UTR//intron       24284625 chr22:31218639-31218640(+) m6A CDS//intron       24284625 chr22:31238681-31238682(+) m6A exon//intron       24284625 chr22:31283508-31283509(+) m6A 5'UTR//CDS       24284625 chr22:31284236-31284237(+) m6A 5'UTR//CDS       24284625//24981863 chr22:31284281-31284282(+) m6A CDS       24284625//24981863 chr22:31284323-31284324(+) m6A CDS       24284625 chr22:31285188-31285189(+) m6A CDS       24284625 chr22:31285201-31285202(+) m6A CDS       24284625 chr22:31285216-31285217(+) m6A CDS       24284625 chr22:31285585-31285586(+) m6A CDS       24284625//25456834//24981863 chr22:31286718-31286719(+) m6A CDS       24284625 chr22:31286760-31286761(+) m6A CDS       24284625 chr22:31286784-31286785(+) m6A CDS       24284625 chr22:31286906-31286907(+) m6A CDS       24284625 chr22:31286919-31286920(+) m6A CDS       24284625 chr22:31289631-31289632(+) m6A CDS//exon       24284625 chr22:31289646-31289647(+) m6A CDS//exon       24284625 chr22:31289654-31289655(+) m6A CDS//exon       24284625 chr22:31289729-31289730(+) m6A CDS//exon//intron       24284625 chr22:31289868-31289869(+) m6A 3'UTR//CDS//exon//intron       24284625//22575960 chr22:31289935-31289936(+) m6A 3'UTR//CDS//exon//intron       24284625//22575960 chr22:31289947-31289948(+) m6A 3'UTR//CDS//exon//intron       24284625//22575960 chr22:31290039-31290040(+) m6A 3'UTR//exon//intron       24284625 chr22:31290046-31290047(+) m6A 3'UTR//exon//intron       24284625 chr22:31290106-31290107(+) m6A 3'UTR//exon//intron       24284625 chr22:31290143-31290144(+) m6A 3'UTR//exon//intron       24284625 chr22:31290150-31290151(+) m6A 3'UTR//exon//intron       24284625 chr22:31290168-31290169(+) m6A 3'UTR//exon//intron       24284625 chr22:31290176-31290177(+) m6A 3'UTR//exon//intron       24284625 chr22:31290189-31290190(+) m6A 3'UTR//exon//intron       24284625 chr22:31290209-31290210(+) m6A 3'UTR//exon//intron       24284625 chr22:31290401-31290402(+) m6A 3'UTR//intron       - chr22:31290425-31290426(+) m6A 3'UTR//intron       - chr22:31290440-31290441(+) m6A 3'UTR//intron       - chr22:31290445-31290446(+) m6A 3'UTR//intron       - chr22:31301837-31301838(+) m6A CDS       - chr22:31302297-31302298(+) m6A 3'UTR//CDS       24284625//24209618 chr22:31302480-31302481(+) m6A 3'UTR       24284625//24209618 chr22:31302565-31302566(+) m6A 3'UTR       24284625//22575960 chr22:31302582-31302583(+) m6A 3'UTR       24284625//22575960 chr22:31302665-31302666(+) m6A 3'UTR       24284625//22575960 chr22:31302947-31302948(+) m6A 3'UTR       24284625 chr22:31303491-31303492(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	OSBP2	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: OSBP2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).