Basic Information:

  VIRBase ID:  

HHID00004711

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          SLC7A11:  NM_014331     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	SLC7A11
miRBase Accession/Entrez ID	MIMAT0000458	23657
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CCBR1//xCT

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SLC7A11	chr4:139094198(-) A-I      intronic chr4:139094601(-) A-I      intronic chr4:139158663(-) A-I      intronic chr4:139158637(-) A-I      intronic chr4:139158391(-) A-I      intronic chr4:139158383(-) A-I      intronic chr4:139114841(-) A-I      intronic chr4:139158261(-) A-I      intronic chr4:139114927(-) A-I      intronic chr4:139094126(-) A-I      intronic chr4:139094135(-) A-I      intronic chr4:139094175(-) A-I      intronic chr4:139158375(-) A-I      intronic chr4:139094224(-) A-I      intronic chr4:139094238(-) A-I      intronic chr4:139094239(-) A-I      intronic chr4:139158278(-) A-I      intronic chr4:139114907(-) A-I      intronic chr4:139114790(-) A-I      intronic chr4:139114761(-) A-I      intronic chr4:139094243(-) A-I      intronic chr4:139094276(-) A-I      intronic chr4:139094288(-) A-I      intronic chr4:139094644(-) A-I      intronic chr4:139094554(-) A-I      intronic chr4:139094559(-) A-I      intronic chr4:139094563(-) A-I      intronic chr4:139094572(-) A-I      intronic chr4:139117923(-) A-I      intronic chr4:139117906(-) A-I      intronic chr4:139117983(-) A-I      intronic chr4:139117952(-) A-I      intronic chr4:139117886(-) A-I      intronic chr4:139117922(-) A-I      intronic chr4:139117962(-) A-I      intronic chr4:139117935(-) A-I      intronic chr4:139117951(-) A-I      intronic chr4:139117851(-) A-I      intronic chr4:139117942(-) A-I      intronic chr4:139117987(-) A-I      intronic chr4:139117946(-) A-I      intronic chr4:139117928(-) A-I      intronic chr4:139118048(-) A-I      intronic chr4:139118017(-) A-I      intronic chr4:139118015(-) A-I      intronic chr4:139118018(-) A-I      intronic chr4:139117989(-) A-I      intronic chr4:139117897(-) A-I      intronic chr4:139117925(-) A-I      intronic chr4:139117920(-) A-I      intronic chr4:139117982(-) A-I      intronic chr4:139118008(-) A-I      intronic chr4:139118007(-) A-I      intronic chr4:139118027(-) A-I      intronic chr4:139117910(-) A-I      intronic chr4:139117919(-) A-I      intronic chr4:139118040(-) A-I      intronic chr4:139118032(-) A-I      intronic chr4:139160030(-) A-I      intronic chr4:139114805(-) A-I      intronic chr4:139109489(-) A-I      intronic chr4:139158689(-) A-I      intronic chr4:139109371(-) A-I      intronic chr4:139161714(-) A-I      intronic chr4:139161531(-) A-I      intronic chr4:139159950(-) A-I      intronic chr4:139159862(-) A-I      intronic chr4:139114890(-) A-I      intronic chr4:139158644(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SLC7A11	chr4:139109371(-) A-I intron -    22327324 chr4:139117851(-) A-I intron -    22028664 chr4:139117886(-) A-I intron -    22028664 chr4:139117897(-) A-I intron -    22028664 chr4:139117906(-) A-I intron -    22028664 chr4:139117910(-) A-I intron -    22028664 chr4:139117919(-) A-I intron -    22028664 chr4:139117920(-) A-I intron -    22028664 chr4:139117922(-) A-I intron -    22028664 chr4:139117923(-) A-I intron -    22028664 chr4:139117925(-) A-I intron -    22028664 chr4:139117928(-) A-I intron -    22028664 chr4:139117935(-) A-I intron -    22028664 chr4:139117942(-) A-I intron -    22028664 chr4:139117946(-) A-I intron -    22028664 chr4:139117951(-) A-I intron -    22028664 chr4:139117952(-) A-I intron -    22028664 chr4:139117962(-) A-I intron -    22028664 chr4:139117982(-) A-I intron -    22028664 chr4:139117983(-) A-I intron -    22028664 chr4:139117987(-) A-I intron -    22028664 chr4:139117989(-) A-I intron -    22028664 chr4:139118007(-) A-I intron -    22028664 chr4:139118008(-) A-I intron -    22028664 chr4:139118015(-) A-I intron -    22028664 chr4:139118017(-) A-I intron -    22028664 chr4:139118018(-) A-I intron -    22028664 chr4:139118027(-) A-I intron -    22028664 chr4:139118032(-) A-I intron -    22028664 chr4:139118040(-) A-I intron -    22028664 chr4:139118046(-) A-I intron -    22028664 chr4:139118048(-) A-I intron -    22028664 chr4:139109371(-) A-G intron -    22484847 chr4:139109489(-) A-G intron -    22484847 chr4:139114768(-) A-G intron -    22484847 chr4:139114805(-) A-G intron -    22484847 chr4:139114890(-) A-G intron -    22484847 chr4:139117928(-) A-G intron -    22484847 chr4:139118003(-) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SLC7A11	chr4:139087456-139087457(-) Y 3'UTR       26075521 chr4:139088047-139088048(-) Y 3'UTR       26075521 chr4:139092288-139092289(-) Y 3'UTR       26075521 chr4:139092959-139092960(-) m6A 3'UTR       27773535//22608085 chr4:139093005-139093006(-) m6A 3'UTR       24981863//27773535//22608085 chr4:139093068-139093069(-) m6A 3'UTR       24981863//27773535//22575960//22608085 chr4:139093100-139093101(-) m6A 3'UTR       24981863//27773535//22575960//22608085 chr4:139093108-139093109(-) m6A 3'UTR       24981863//27773535//22575960//22608085 chr4:139093156-139093157(-) m6A 3'UTR//CDS       24981863//27773535//22575960//22608085 chr4:139100395-139100396(-) m6A 3'UTR//CDS       24981863//27773535//22575960//22608085 chr4:139100402-139100403(-) m6A 3'UTR//CDS       24981863//27773535//22575960//22608085 chr4:139100477-139100478(-) m6A 3'UTR//CDS       24981863 chr4:139163286-139163287(-) m6A 5'UTR       24981863//26404942//22608085 chr4:139163309-139163310(-) m6A 5'UTR       24981863//26404942//22608085 chr4:139163330-139163331(-) m6A 5'UTR       24981863//26404942//27773535//22608085 chr4:139163350-139163351(-) m6A 5'UTR       24981863//26404942//27773535//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	SLC7A11	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol HeLa-S3 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: SLC7A11

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).