Basic Information:

  VIRBase ID:  

HHID00004709

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          RABGAP1:  NM_012197     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	RABGAP1
miRBase Accession/Entrez ID	MIMAT0000458	23637
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	GAPCENA//TBC1D11

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RABGAP1	chr9:125711758(+) A-I      intronic chr9:125715846(+) A-I      intronic chr9:125721161(+) A-I      intronic chr9:125728682(+) A-I      intronic chr9:125730105(+) A-I      intronic chr9:125730106(+) A-I      intronic chr9:125731128(+) A-I      intronic chr9:125735603(+) A-I      intronic chr9:125735697(+) A-I      intronic chr9:125735700(+) A-I      intronic chr9:125735722(+) A-I      intronic chr9:125736110(+) A-I      intronic chr9:125736168(+) A-I      intronic chr9:125736201(+) A-I      intronic chr9:125736209(+) A-I      intronic chr9:125739730(+) A-I      intronic chr9:125741231(+) A-I      intronic chr9:125741405(+) A-I      intronic chr9:125743539(+) A-I      intronic chr9:125744260(+) A-I      intronic chr9:125754048(+) A-I      intronic chr9:125757217(+) A-I      intronic chr9:125757230(+) A-I      intronic chr9:125788482(+) A-I      intronic chr9:125788515(+) A-I      intronic chr9:125850792(+) A-I      intronic chr9:125754068(+) A-I      intronic chr9:125754367(+) A-I      intronic chr9:125754455(+) A-I      intronic chr9:125754458(+) A-I      intronic chr9:125754461(+) A-I      intronic chr9:125755731(+) A-I      intronic chr9:125756023(+) A-I      intronic chr9:125756036(+) A-I      intronic chr9:125756042(+) A-I      intronic chr9:125757928(+) A-I      intronic chr9:125757965(+) A-I      intronic chr9:125757993(+) A-I      intronic chr9:125761499(+) A-I      intronic chr9:125761526(+) A-I      intronic chr9:125761543(+) A-I      intronic chr9:125766667(+) A-I      intronic chr9:125766671(+) A-I      intronic chr9:125766751(+) A-I      intronic chr9:125789560(+) A-I      intronic chr9:125766755(+) A-I      intronic chr9:125767185(+) A-I      intronic chr9:125768966(+) A-I      intronic chr9:125768999(+) A-I      intronic chr9:125769039(+) A-I      intronic chr9:125769140(+) A-I      intronic chr9:125770661(+) A-I      intronic chr9:125770704(+) A-I      intronic chr9:125774020(+) A-I      intronic chr9:125774119(+) A-I      intronic chr9:125774155(+) A-I      intronic chr9:125774183(+) A-I      intronic chr9:125753985(+) A-I      intronic chr9:125785515(+) A-I      intronic chr9:125704834(+) A-I      intronic chr9:125704839(+) A-I      intronic chr9:125785539(+) A-I      intronic chr9:125704890(+) A-I      intronic chr9:125705548(+) A-I      intronic chr9:125705610(+) A-I      intronic chr9:125705622(+) A-I      intronic chr9:125706045(+) A-I      intronic chr9:125706089(+) A-I      intronic chr9:125706101(+) A-I      intronic chr9:125706111(+) A-I      intronic chr9:125706117(+) A-I      intronic chr9:125706121(+) A-I      intronic chr9:125706606(+) A-I      intronic chr9:125706950(+) A-I      intronic chr9:125706952(+) A-I      intronic chr9:125706967(+) A-I      intronic chr9:125706991(+) A-I      intronic chr9:125707007(+) A-I      intronic chr9:125707030(+) A-I      intronic chr9:125707036(+) A-I      intronic chr9:125707053(+) A-I      intronic chr9:125707065(+) A-I      intronic chr9:125707085(+) A-I      intronic chr9:125707124(+) A-I      intronic chr9:125711377(+) A-I      intronic chr9:125711399(+) A-I      intronic chr9:125711636(+) A-I      intronic chr9:125711703(+) A-I      intronic chr9:125785558(+) A-I      intronic chr9:125713871(+) A-I      intronic chr9:125713929(+) A-I      intronic chr9:125713966(+) A-I      intronic chr9:125713978(+) A-I      intronic chr9:125785740(+) A-I      intronic chr9:125786819(+) A-I      intronic chr9:125788476(+) A-I      intronic chr9:125788483(+) A-I      intronic chr9:125788509(+) A-I      intronic chr9:125788535(+) A-I      intronic chr9:125789524(+) A-I      intronic chr9:125814345(+) A-I      intronic chr9:125814367(+) A-I      intronic chr9:125815060(+) A-I      intronic chr9:125815131(+) A-I      intronic chr9:125815140(+) A-I      intronic chr9:125815168(+) A-I      intronic chr9:125850598(+) A-I      intronic chr9:125850814(+) A-I      intronic chr9:125850817(+) A-I      intronic chr9:125857426(+) A-I      intronic chr9:125857451(+) A-I      intronic chr9:125857702(+) A-I      intronic chr9:125857914(+) A-I      intronic chr9:125857747(+) A-I      intronic chr9:125857777(+) A-I      intronic chr9:125857852(+) A-I      intronic chr9:125713988(+) A-I      intronic chr9:125714006(+) A-I      intronic chr9:125713994(+) A-I      intronic chr9:125713990(+) A-I      intronic chr9:125857831(+) A-I      intronic chr9:125713881(+) A-I      intronic chr9:125735634(+) A-I      intronic chr9:125713953(+) A-I      intronic chr9:125706826(+) A-I      intronic chr9:125731162(+) A-I      intronic chr9:125730566(+) A-I      intronic chr9:125843739(+) A-I      intronic chr9:125814962(+) A-I      intronic chr9:125859031(+) A-I      intronic chr9:125757341(+) A-I      intronic chr9:125825303(+) A-I      intronic chr9:125767174(+) A-I      intronic chr9:125786788(+) A-I      intronic chr9:125789460(+) A-I      intronic chr9:125770730(+) A-I      intronic chr9:125789512(+) A-I      intronic chr9:125815025(+) A-I      intronic chr9:125815139(+) A-I      intronic chr9:125788424(+) A-I      intronic chr9:125824394(+) A-I      intronic chr9:125775672(+) A-I      intronic chr9:125815098(+) A-I      intronic chr9:125721157(+) A-I      intronic chr9:125711645(+) A-I      intronic chr9:125736124(+) A-I      intronic chr9:125850912(+) A-I      intronic chr9:125767241(+) A-I      intronic chr9:125732445(+) A-I      intronic chr9:125785643(+) A-I      intronic chr9:125741257(+) A-I      intronic chr9:125769960(+) A-I      intronic chr9:125757378(+) A-I      intronic chr9:125732121(+) A-I      intronic chr9:125728653(+) A-I      intronic chr9:125760562(+) A-I      intronic chr9:125711641(+) A-I      intronic chr9:125788383(+) A-I      intronic chr9:125728648(+) A-I      intronic chr9:125743527(+) A-I      intronic chr9:125706989(+) A-I      intronic chr9:125704812(+) A-I      intronic chr9:125788552(+) A-I      intronic chr9:125743478(+) A-I      intronic chr9:125742586(+) A-I      intronic chr9:125724815(+) A-I      intronic chr9:125766679(+) A-I      intronic chr9:125730917(+) A-I      intronic chr9:125732035(+) A-I      intronic chr9:125721133(+) A-I      intronic chr9:125786956(+) A-I      intronic chr9:125850820(+) A-I      intronic chr9:125713975(+) A-I      intronic chr9:125756108(+) A-I      intronic chr9:125766797(+) A-I      intronic chr9:125857842(+) A-I      intronic chr9:125704869(+) A-I      intronic chr9:125825142(+) A-I      intronic chr9:125774058(+) A-I      intronic chr9:125786899(+) A-I      intronic chr9:125714035(+) A-I      intronic chr9:125767177(+) A-I      intronic chr9:125858987(+) A-I      intronic chr9:125753982(+) A-I      intronic chr9:125732107(+) A-I      intronic chr9:125732119(+) A-I      intronic chr9:125830557(+) A-I      intronic chr9:125764366(+) A-I      intronic chr9:125730044(+) A-I      intronic chr9:125705508(+) A-I      intronic chr9:125732592(+) A-I      intronic chr9:125788438(+) A-I      intronic chr9:125730187(+) A-I      intronic chr9:125757214(+) A-I      intronic chr9:125739771(+) A-I      intronic chr9:125770687(+) A-I      intronic chr9:125728645(+) A-I      intronic chr9:125815053(+) A-I      intronic chr9:125732634(+) A-I      intronic chr9:125770765(+) A-I      intronic chr9:125788456(+) A-I      intronic chr9:125741252(+) A-I      intronic chr9:125707130(+) A-I      intronic chr9:125786919(+) A-I      intronic chr9:125813788(+) A-I      intronic chr9:125713919(+) A-I      intronic chr9:125823560(+) A-I      intronic chr9:125815169(+) A-I      intronic chr9:125715703(+) A-I      intronic chr9:125711827(+) A-I      intronic chr9:125743397(+) A-I      intronic chr9:125714970(+) A-I      intronic chr9:125814349(+) A-I      intronic chr9:125766684(+) A-I      intronic chr9:125815099(+) A-I      intronic chr9:125775664(+) A-I      intronic chr9:125739805(+) A-I      intronic chr9:125734488(+) A-I      intronic chr9:125757321(+) A-I      intronic chr9:125857803(+) A-I      intronic chr9:125824453(+) A-I      intronic chr9:125770667(+) A-I      intronic chr9:125767256(+) A-I      intronic chr9:125721078(+) A-I      intronic chr9:125766646(+) A-I      intronic chr9:125766814(+) A-I      intronic chr9:125769492(+) A-I      intronic chr9:125732619(+) A-I      intronic chr9:125823434(+) A-I      intronic chr9:125706949(+) A-I      intronic chr9:125739731(+) A-I      intronic chr9:125815022(+) A-I      intronic chr9:125730685(+) A-I      intronic chr9:125707056(+) A-I      intronic chr9:125824395(+) A-I      intronic chr9:125813627(+) A-I      intronic chr9:125705176(+) A-I      intronic chr9:125711961(+) A-I      intronic chr9:125850442(+) A-I      intronic chr9:125707133(+) A-I      intronic chr9:125714935(+) A-I      intronic chr9:125741277(+) A-I      intronic chr9:125767214(+) A-I      intronic chr9:125775791(+) A-I      intronic chr9:125785625(+) A-I      intronic chr9:125857383(+) A-I      intronic chr9:125770753(+) A-I      intronic chr9:125736129(+) A-I      intronic chr9:125711400(+) A-I      intronic chr9:125714975(+) A-I      intronic chr9:125730643(+) A-I      intronic chr9:125744176(+) A-I      intronic chr9:125743543(+) A-I      intronic chr9:125832069(+) A-I      intronic chr9:125715870(+) A-I      intronic chr9:125732680(+) A-I      intronic chr9:125830563(+) A-I      intronic chr9:125850364(+) A-I      intronic chr9:125757275(+) A-I      intronic chr9:125734506(+) A-I      intronic chr9:125775846(+) A-I      intronic chr9:125740834(+) A-I      intronic chr9:125785730(+) A-I      intronic chr9:125788480(+) A-I      intronic chr9:125766644(+) A-I      intronic chr9:125713949(+) A-I      intronic chr9:125732092(+) A-I      intronic chr9:125767255(+) A-I      intronic chr9:125850495(+) A-I      intronic chr9:125713950(+) A-I      intronic chr9:125824301(+) A-I      intronic chr9:125757134(+) A-I      intronic chr9:125850901(+) A-I      intronic chr9:125850816(+) A-I      intronic chr9:125706979(+) A-I      intronic chr9:125813800(+) A-I      intronic chr9:125763312(+) A-I      intronic chr9:125788492(+) A-I      intronic chr9:125824316(+) A-I      intronic chr9:125766598(+) A-I      intronic chr9:125704791(+) A-I      intronic chr9:125850416(+) A-I      intronic chr9:125704802(+) A-I      intronic chr9:125757948(+) A-I      intronic chr9:125770647(+) A-I      intronic chr9:125850469(+) A-I      intronic chr9:125730682(+) A-I      intronic chr9:125728579(+) A-I      intronic chr9:125769004(+) A-I      intronic chr9:125850970(+) A-I      intronic chr9:125757253(+) A-I      intronic chr9:125857920(+) A-I      intronic chr9:125713905(+) A-I      intronic chr9:125757249(+) A-I      intronic chr9:125743396(+) A-I      intronic chr9:125850900(+) A-I      intronic chr9:125857844(+) A-I      intronic chr9:125714054(+) A-I      intronic chr9:125824281(+) A-I      intronic chr9:125767081(+) A-I      intronic chr9:125788393(+) A-I      intronic chr9:125823532(+) A-I      intronic chr9:125706638(+) A-I      intronic chr9:125728656(+) A-I      intronic chr9:125740824(+) A-I      intronic chr9:125767175(+) A-I      intronic chr9:125745059(+) A-I      intronic chr9:125736128(+) A-I      intronic chr9:125761485(+) A-I      intronic chr9:125857946(+) A-I      intronic chr9:125706837(+) A-I      intronic chr9:125706567(+) A-I      intronic chr9:125769071(+) A-I      intronic chr9:125758028(+) A-I      intronic chr9:125858928(+) A-I      intronic chr9:125735714(+) A-I      intronic chr9:125728618(+) A-I      intronic chr9:125788348(+) A-I      intronic chr9:125743348(+) A-I      intronic chr9:125704793(+) A-I      intronic chr9:125850852(+) A-I      intronic chr9:125850415(+) A-I      intronic chr9:125788402(+) A-I      intronic chr9:125840041(+) A-I      intronic chr9:125857746(+) A-I      intronic chr9:125743544(+) A-I      intronic chr9:125769710(+) A-I      intronic chr9:125814358(+) A-I      intronic chr9:125758050(+) A-I      intronic chr9:125857915(+) A-I      intronic chr9:125705251(+) A-I      intronic chr9:125770614(+) A-I      intronic chr9:125850430(+) A-I      intronic chr9:125774114(+) A-I      intronic chr9:125730592(+) A-I      intronic chr9:125732708(+) A-I      intronic chr9:125724677(+) A-I      intronic chr9:125744108(+) A-I      intronic chr9:125721030(+) A-I      intronic chr9:125744175(+) A-I      intronic chr9:125858904(+) A-I      intronic chr9:125707095(+) A-I      intronic chr9:125705977(+) A-I      intronic chr9:125774184(+) A-I      intronic chr9:125714908(+) A-I      intronic chr9:125766707(+) A-I      intronic chr9:125858965(+) A-I      intronic chr9:125757140(+) A-I      intronic chr9:125813666(+) A-I      intronic chr9:125744113(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RABGAP1	chr9:125724006(+) A-I intron -    22327324 chr9:125723986(+) A-G intron -    22484847 chr9:125723995(+) A-G intron -    22484847 chr9:125725874(+) A-G intron -    22484847 chr9:125725875(+) A-G intron -    22484847 chr9:125704709(+) A-G intron -    22484847 chr9:125711991(+) G-A intron -    22484847 chr9:125730026(+) T-A intron -    22484847 chr9:125752891(+) A-G intron -    22484847 chr9:125752928(+) A-G intron -    22484847 chr9:125850469(+) A-G intron -    22484847 chr9:125857844(+) A-G intron -    22484847 chr9:125857920(+) A-G intron -    22484847 chr9:125859037(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RABGAP1	chr9:125703291-125703292(+) m6A 5'UTR//intron       24981863 chr9:125707642-125707643(+) m6A 5'UTR//intron       24981863 chr9:125733978-125733979(+) m6A 5'UTR//intron       24981863 chr9:125734226-125734227(+) m6A 5'UTR//intron       24981863 chr9:125746783-125746784(+) m6A 5'UTR//CDS//exon//intron       24981863 chr9:125751657-125751658(+) m6A 3'UTR//CDS//exon       24284625 chr9:125751768-125751769(+) m6A exon//intron       24284625 chr9:125751784-125751785(+) m6A exon//intron       24284625 chr9:125752388-125752389(+) m6A 3'UTR//CDS//exon       - chr9:125752418-125752419(+) m6A 3'UTR//CDS//exon       - chr9:125852089-125852090(+) m6A 3'UTR//CDS//exon       24981863 chr9:125852109-125852110(+) m6A 3'UTR//CDS//exon       24981863 chr9:125852594-125852595(+) m6A 3'UTR//CDS//exon       24981863 chr9:125852653-125852654(+) m6A 3'UTR//CDS//exon       24981863 chr9:125860066-125860067(+) m6A 3'UTR//CDS       24981863 chr9:125861016-125861017(+) m6A 3'UTR//CDS       24981863 chr9:125861048-125861049(+) m6A 3'UTR//CDS       24981863 chr9:125861795-125861796(+) m6A 3'UTR//CDS       24981863//27773535 chr9:125863938-125863939(+) m6A 3'UTR//CDS       24209618//24981863//22608085 chr9:125863968-125863969(+) m6A 3'UTR//CDS       24209618//24981863//22608085 chr9:125863993-125863994(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr9:125864003-125864004(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr9:125864008-125864009(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr9:125865377-125865378(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085 chr9:125865438-125865439(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085 chr9:125865456-125865457(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085 chr9:125865483-125865484(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:125865524-125865525(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr9:125865583-125865584(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr9:125865634-125865635(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr9:125865670-125865671(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr9:125865713-125865714(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr9:125866424-125866425(+) Y 3'UTR       26075521

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	RABGAP1	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: RABGAP1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).