Basic Information:

  VIRBase ID:  

HHID00004677

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          EFR3A:  NR_136616     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	EFR3A
miRBase Accession/Entrez ID	MIMAT0000458	23167
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	EFR3A	chr8:132922658(+) A-I      intronic chr8:132921636(+) A-I      intronic chr8:132922550(+) A-I      intronic chr8:132921647(+) A-I      intronic chr8:132922557(+) A-I      intronic chr8:132922599(+) A-I      intronic chr8:132998934(+) A-I      intronic chr8:132921663(+) A-I      intronic chr8:132921699(+) A-I      intronic chr8:132921673(+) A-I      intronic chr8:132922794(+) A-I      intronic chr8:132921671(+) A-I      intronic chr8:132921602(+) A-I      intronic chr8:132922623(+) A-I      intronic chr8:132922648(+) A-I      intronic chr8:133006391(+) A-I      intronic chr8:132921612(+) A-I      intronic chr8:132921536(+) A-I      intronic chr8:132921616(+) A-I      intronic chr8:132921629(+) A-I      intronic chr8:132921534(+) A-I      intronic chr8:132921597(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	EFR3A	chr8:132921520(+) A-G intron -    22484847 chr8:132921534(+) A-G intron -    22484847 chr8:132921536(+) A-G intron -    22484847 chr8:132921597(+) A-G intron -    22484847 chr8:132921616(+) A-G intron -    22484847 chr8:132921629(+) A-G intron -    22484847 chr8:132921651(+) A-G intron -    22484847 chr8:132921713(+) A-G intron -    22484847 chr8:132922703(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	EFR3A	chr8:132958758-132958759(+) m6A CDS       - chr8:132991643-132991644(+) m6A CDS       24981863 chr8:132991648-132991649(+) m6A CDS       24981863 chr8:132996434-132996435(+) m6A CDS//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	EFR3A	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: EFR3A

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).