Basic Information:

  VIRBase ID:  

HHID00004653

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          CNKSR2:  NM_001168649     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	CNKSR2
miRBase Accession/Entrez ID	MIMAT0000458	22866
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CNK2//KSR2//MAGUIN//MRXSHG

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CNKSR2	chrX:21652713(+) A-I      intronic chrX:21652708(+) A-I      intronic chrX:21652701(+) A-I      intronic chrX:21504093(+) A-I      intronic chrX:21467270(+) A-I      intronic chrX:21467279(+) A-I      intronic chrX:21406269(+) A-I      intronic chrX:21610557(+) A-I      intronic chrX:21610556(+) A-I      intronic chrX:21503215(+) A-I      intronic chrX:21652734(+) A-I      intronic chrX:21652663(+) A-I      intronic chrX:21652682(+) A-I      intronic chrX:21652696(+) A-I      intronic chrX:21504097(+) A-I      intronic chrX:21652732(+) A-I      intronic chrX:21406224(+) A-I      intronic chrX:21617583(+) A-I      intronic chrX:21487843(+) A-I      intronic chrX:21405461(+) A-I      intronic chrX:21406278(+) A-I      intronic chrX:21406279(+) A-I      intronic chrX:21631911(+) A-I      intronic chrX:21470348(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CNKSR2	chrX:21392669-21392670(+) m6A 5'UTR       24981863 chrX:21392692-21392693(+) m6A 5'UTR       24981863 chrX:21392775-21392776(+) m6A 5'UTR       24981863 chrX:21392784-21392785(+) m6A 5'UTR       24981863 chrX:21392871-21392872(+) m6A 5'UTR       24981863 chrX:21613509-21613510(+) m6A CDS       24981863 chrX:21619462-21619463(+) m6A CDS       24981863 chrX:21624948-21624949(+) m6A CDS       24981863 chrX:21627323-21627324(+) m6A CDS       22575960 chrX:21627398-21627399(+) m6A CDS       24981863//22575960 chrX:21627720-21627721(+) m6A CDS       24981863 chrX:21659676-21659677(+) m6A 3'UTR//intron       24981863 chrX:21659726-21659727(+) m6A 3'UTR//intron       24981863 chrX:21659854-21659855(+) m6A 3'UTR//intron       - chrX:21659960-21659961(+) m6A 3'UTR//intron       25456834 chrX:21660007-21660008(+) m6A 3'UTR//intron       25456834 chrX:21660027-21660028(+) m6A 3'UTR//intron       25456834 chrX:21670463-21670464(+) m6A CDS       24981863 chrX:21670472-21670473(+) m6A CDS       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	CNKSR2	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: CNKSR2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).