Detail Information

Basic Information:


  VIRBase ID:  

HHID00004611

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:           ZNF460:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-5p ZNF460
miRBase
Accession/Entrez ID		 MIMAT0000458 10794
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - HZF8//ZNF272

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-5p
rs1018706777 chr15:62823984    A/G
rs1369926402 chr15:62823991    G/A
rs1555521311 chr15:62823990    G/C
rs755866868 chr15:62823986    A/G
rs766742872 chr15:62823990    GGTT/G
rs777464613 chr15:62823987    T/G
rs1228899174 chr15:62823974    T/A
rs1281303771 chr15:62823976    T/C
rs1350000299 chr15:62823972    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ZNF460
chr19:57801829(+) A-I      intronic
chr19:57795150(+) A-I      intronic
chr19:57801881(+) A-I      intronic
chr19:57794148(+) A-I      intronic
chr19:57794156(+) A-I      intronic
chr19:57795109(+) A-I      intronic
chr19:57795144(+) A-I      intronic
chr19:57798120(+) A-I      intronic
chr19:57798143(+) A-I      intronic
chr19:57798153(+) A-I      intronic
chr19:57798154(+) A-I      intronic
chr19:57799203(+) A-I      intronic
chr19:57799207(+) A-I      intronic
chr19:57799214(+) A-I      intronic
chr19:57801121(+) A-I      intronic
chr19:57801284(+) A-I      intronic
chr19:57801353(+) A-I      intronic
chr19:57801357(+) A-I      intronic
chr19:57801428(+) A-I      intronic
chr19:57801866(+) A-I      intronic
chr19:57801826(+) A-I      intronic
chr19:57801347(+) A-I      intronic
chr19:57801528(+) A-I      intronic
chr19:57801525(+) A-I      intronic
chr19:57799226(+) A-I      intronic
chr19:57801811(+) A-I      intronic
chr19:57801785(+) A-I      intronic
chr19:57801620(+) A-I      intronic
chr19:57801541(+) A-I      intronic
chr19:57794255(+) A-I      intronic
chr19:57799657(+) A-I      intronic
chr19:57801323(+) A-I      intronic
chr19:57794103(+) A-I      intronic
chr19:57801739(+) A-I      intronic
chr19:57798144(+) A-I      intronic
chr19:57794096(+) A-I      intronic
chr19:57801763(+) A-I      intronic
chr19:57795104(+) A-I      intronic
chr19:57794212(+) A-I      intronic
chr19:57794274(+) A-I      intronic
chr19:57798877(+) A-I      intronic
chr19:57794277(+) A-I      intronic
chr19:57799307(+) A-I      intronic
chr19:57799210(+) A-I      intronic
chr19:57799640(+) A-I      intronic
chr19:57794743(+) A-I      intronic
chr19:57794638(+) A-I      intronic
chr19:57801093(+) A-I      intronic
chr19:57799594(+) A-I      intronic
chr19:57798874(+) A-I      intronic
chr19:57799277(+) A-I      intronic
chr19:57795079(+) A-I      intronic
chr19:57801527(+) A-I      intronic
chr19:57799234(+) A-I      intronic
chr19:57801294(+) A-I      intronic
chr19:57794252(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ZNF460
chr19:57794277(+) A-I intron -    22327324
chr19:57799640(+) A-I intron -    21960545
chr19:57799656(+) A-I intron -    21960545
chr19:57794277(+) A-G intron -    22484847
chr19:57801270(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZNF460
chr19:57792086-57792087(+) m6A 5'UTR//intron       24284625
chr19:57792132-57792133(+) m6A 5'UTR//intron       24284625
chr19:57793324-57793325(+) m6A 5'UTR//intron       -
chr19:57796020-57796021(+) m6A CDS       24284625//24209618//22575960//22608085
chr19:57802079-57802080(+) m6A CDS       24284625//24209618//22575960//22608085
chr19:57802086-57802087(+) m6A CDS       24284625//24209618//22575960//22608085
chr19:57802142-57802143(+) m6A CDS       24284625//24209618//24981863//22575960//22608085
chr19:57802232-57802233(+) m6A CDS       24284625//24209618//24981863//22575960//22608085
chr19:57802239-57802240(+) m6A CDS       24284625//24209618//24981863//22575960//22608085
chr19:57802243-57802244(+) m6A CDS       25456834//24981863
chr19:57802259-57802260(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr19:57802283-57802284(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr19:57802333-57802334(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr19:57802379-57802380(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr19:57802535-57802536(+) m6A CDS       24284625//24981863//22575960//22608085
chr19:57802603-57802604(+) m6A CDS       24284625//25456834//24981863//22575960//22608085
chr19:57802641-57802642(+) m6A CDS       24284625//25456834//24981863//22575960//22608085
chr19:57802686-57802687(+) m6A CDS       24284625//25456834//24981863//22575960//22608085
chr19:57802826-57802827(+) m6A CDS       24284625//22608085
chr19:57803125-57803126(+) m6A CDS       24284625//24981863//26404942//22608085
chr19:57803286-57803287(+) m6A CDS       24284625//24981863//22575960//22608085
chr19:57803293-57803294(+) m6A CDS       24284625//24981863//22575960//22608085
chr19:57803423-57803424(+) m6A CDS       24284625//24209618//24981863//22575960//22608085
chr19:57803583-57803584(+) m6A CDS       24284625//24209618//24981863//22575960//22608085
chr19:57803611-57803612(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085
chr19:57803705-57803706(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085
chr19:57803740-57803741(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085
chr19:57803768-57803769(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085
chr19:57803798-57803799(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085
chr19:57803866-57803867(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr19:57803894-57803895(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22575960//22608085
chr19:57803945-57803946(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr19:57803953-57803954(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085
chr19:57804009-57804010(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr19:57804081-57804082(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085
chr19:57804144-57804145(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085
chr19:57804163-57804164(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085
chr19:57804593-57804594(+) m6A 3'UTR       24981863//27773535//22608085
chr19:57804610-57804611(+) m6A 3'UTR       24981863//27773535//22608085
chr19:57804645-57804646(+) m6A 3'UTR       24981863//27773535//22608085
chr19:57804658-57804659(+) m6A 3'UTR       24981863//27773535//22608085
chr19:57804746-57804747(+) m6A 3'UTR       24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-5p
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
ZNF460
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-5p
Interactor2: ZNF460

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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