Detail Information

Basic Information:


  VIRBase ID:  

HHID00004545

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:           SPATA2:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-5p SPATA2
miRBase
Accession/Entrez ID		 MIMAT0000458 9825
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - PD1//PPP1R145//tamo

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-5p
rs1018706777 chr15:62823984    A/G
rs1369926402 chr15:62823991    G/A
rs1555521311 chr15:62823990    G/C
rs755866868 chr15:62823986    A/G
rs766742872 chr15:62823990    GGTT/G
rs777464613 chr15:62823987    T/G
rs1228899174 chr15:62823974    T/A
rs1281303771 chr15:62823976    T/C
rs1350000299 chr15:62823972    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SPATA2
chr20:48528828(-) A-I      intronic
chr20:48525688(-) A-I      intronic
chr20:48525720(-) A-I      intronic
chr20:48525723(-) A-I      intronic
chr20:48528774(-) A-I      intronic
chr20:48525753(-) A-I      intronic
chr20:48523868(-) A-I      intronic
chr20:48526085(-) A-I      intronic
chr20:48526025(-) A-I      intronic
chr20:48527495(-) A-I      intronic
chr20:48523833(-) A-I      intronic
chr20:48528734(-) A-I      intronic
chr20:48525832(-) A-I      intronic
chr20:48525595(-) A-I      intronic
chr20:48526051(-) A-I      intronic
chr20:48525597(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SPATA2
chr20:48526025(-) A-I intron -    21960545

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SPATA2
chr20:48520113-48520114(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085
chr20:48520191-48520192(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22608085
chr20:48520694-48520695(-) m6A 3'UTR       24981863
chr20:48520917-48520918(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr20:48521019-48521020(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr20:48521041-48521042(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr20:48521055-48521056(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr20:48521080-48521081(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr20:48521209-48521210(-) m6A 3'UTR       24284625
chr20:48521460-48521461(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr20:48521502-48521503(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr20:48521569-48521570(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr20:48521615-48521616(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr20:48521635-48521636(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828
chr20:48521742-48521743(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828
chr20:48521769-48521770(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828
chr20:48521811-48521812(-) m6A 3'UTR       24284625//25456834//24981863//27773535
chr20:48522154-48522155(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085
chr20:48522195-48522196(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr20:48522409-48522410(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960
chr20:48522692-48522693(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828
chr20:48522699-48522700(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828
chr20:48522996-48522997(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22608085
chr20:48523143-48523144(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr20:48523164-48523165(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr20:48523252-48523253(-) m6A CDS       24284625//25456834//24981863//27773535//27371828
chr20:48523329-48523330(-) m6A CDS       24284625

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-5p
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
SPATA2
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-5p
Interactor2: SPATA2

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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