Basic Information:

  VIRBase ID:  

HHID00004510

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          ITM2B:  NM_021999     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	ITM2B
miRBase Accession/Entrez ID	MIMAT0000458	9445
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ABRI//BRI//BRI2//BRICD2B//E25B//E3-16//FBD//imBRI2//RDGCA

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ITM2B	chr13:48821176(+) A-I      intronic chr13:48821148(+) A-I      intronic chr13:48821126(+) A-I      intronic chr13:48813689(+) A-I      intronic chr13:48813688(+) A-I      intronic chr13:48809972(+) A-I      intronic chr13:48813680(+) A-I      intronic chr13:48813672(+) A-I      intronic chr13:48819275(+) A-I      intronic chr13:48819223(+) A-I      intronic chr13:48819207(+) A-I      intronic chr13:48817878(+) A-I      intronic chr13:48814483(+) A-I      intronic chr13:48814468(+) A-I      intronic chr13:48813521(+) A-I      intronic chr13:48817769(+) A-I      intronic chr13:48819358(+) A-I      intronic chr13:48819382(+) A-I      intronic chr13:48824679(+) A-I      intronic chr13:48824674(+) A-I      intronic chr13:48822472(+) A-I      intronic chr13:48819932(+) A-I      intronic chr13:48820121(+) A-I      intronic chr13:48819995(+) A-I      intronic chr13:48819276(+) A-I      intronic chr13:48820019(+) A-I      intronic chr13:48821152(+) A-I      intronic chr13:48821164(+) A-I      intronic chr13:48821173(+) A-I      intronic chr13:48819341(+) A-I      intronic chr13:48824633(+) A-I      intronic chr13:48824536(+) A-I      intronic chr13:48824643(+) A-I      intronic chr13:48824662(+) A-I      intronic chr13:48819357(+) A-I      intronic chr13:48817881(+) A-I      intronic chr13:48817916(+) A-I      intronic chr13:48819936(+) A-I      intronic chr13:48813664(+) A-I      intronic chr13:48817707(+) A-I      intronic chr13:48819306(+) A-I      intronic chr13:48813671(+) A-I      intronic chr13:48821224(+) A-I      intronic chr13:48819315(+) A-I      intronic chr13:48824501(+) A-I      intronic chr13:48814441(+) A-I      intronic chr13:48813589(+) A-I      intronic chr13:48817832(+) A-I      intronic chr13:48813561(+) A-I      intronic chr13:48814540(+) A-I      intronic chr13:48814393(+) A-I      intronic chr13:48817715(+) A-I      intronic chr13:48813538(+) A-I      intronic chr13:48813621(+) A-I      intronic chr13:48814442(+) A-I      intronic chr13:48813653(+) A-I      intronic chr13:48821236(+) A-I      intronic chr13:48819198(+) A-I      intronic chr13:48826563(+) A-I      intronic chr13:48820438(+) A-I      intronic chr13:48813516(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ITM2B	chr13:48813621(+) A-I intron -    21960545

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ITM2B	chr13:48807374-48807375(+) m6A 5'UTR       24209618//25456834//24981863//27371828//22575960 chr13:48807605-48807606(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27371828 chr13:48828005-48828006(+) m6A CDS       25456834 chr13:48829056-48829057(+) m6A CDS//intron       27773535 chr13:48832263-48832264(+) m6A 3'UTR//CDS//intron       27773535 chr13:48832316-48832317(+) m6A 3'UTR//CDS//intron       27773535 chr13:48832343-48832344(+) m6A 3'UTR//CDS//intron       27773535 chr13:48832938-48832939(+) m6A 3'UTR//CDS       27773535 chr13:48832999-48833000(+) m6A 3'UTR//CDS       27773535 chr13:48833049-48833050(+) m6A 3'UTR//CDS       27773535 chr13:48833057-48833058(+) m6A 3'UTR//CDS       27773535 chr13:48833073-48833074(+) m6A 3'UTR//CDS       27773535 chr13:48835325-48835326(+) m6A CDS       26404942//27773535 chr13:48835342-48835343(+) m6A CDS       26404942//27773535 chr13:48835360-48835361(+) m6A 3'UTR       26404942//27773535 chr13:48835373-48835374(+) m6A 3'UTR       26404942//27773535 chr13:48835468-48835469(+) m6A 3'UTR//intron       27773535 chr13:48835509-48835510(+) m6A 3'UTR//intron       27773535 chr13:48835725-48835726(+) m6A 3'UTR//intron       26404942//27773535 chr13:48836010-48836011(+) m6A 3'UTR//intron       27773535 chr13:48836039-48836040(+) m6A 3'UTR//intron       27773535 chr13:48836093-48836094(+) m6A 3'UTR//intron       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	ITM2B	Cytosol HCC cell line (HepG2)     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: ITM2B

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).