Basic Information:

  VIRBase ID:  

HHID00004485

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          ARHGEF1:  NM_199002     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	ARHGEF1
miRBase Accession/Entrez ID	MIMAT0000458	9138
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	GEF1//IMD62//LBCL2//LSC//P115-RHOGEF//SUB1.5

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ARHGEF1	chr19:42394650(+) A-I      intronic chr19:42394651(+) A-I      intronic chr19:42394845(+) A-I      intronic chr19:42394850(+) A-I      intronic chr19:42394846(+) A-I      intronic chr19:42405191(+) A-I      intronic chr19:42405034(+) A-I      intronic chr19:42405027(+) A-I      intronic chr19:42404996(+) A-I      intronic chr19:42403804(+) A-I      intronic chr19:42403798(+) A-I      intronic chr19:42403788(+) A-I      intronic chr19:42403739(+) A-I      intronic chr19:42403676(+) A-I      intronic chr19:42395651(+) A-I      intronic chr19:42394954(+) A-I      intronic chr19:42394854(+) A-I      intronic chr19:42394386(+) A-I      intronic chr19:42404379(+) A-I      intronic chr19:42404354(+) A-I      intronic chr19:42404344(+) A-I      intronic chr19:42404341(+) A-I      intronic chr19:42404330(+) A-I      intronic chr19:42404211(+) A-I      intronic chr19:42403825(+) A-I      intronic chr19:42394740(+) A-I      intronic chr19:42395453(+) A-I      intronic chr19:42394309(+) A-I      intronic chr19:42395535(+) A-I      intronic chr19:42394460(+) A-I      intronic chr19:42394695(+) A-I      intronic chr19:42404362(+) A-I      intronic chr19:42394516(+) A-I      intronic chr19:42404384(+) A-I      intronic chr19:42395629(+) A-I      intronic chr19:42395538(+) A-I      intronic chr19:42404385(+) A-I      intronic chr19:42404312(+) A-I      intronic chr19:42395457(+) A-I      intronic chr19:42403235(+) A-I      intronic chr19:42395415(+) A-I      intronic chr19:42404245(+) A-I      intronic chr19:42394708(+) A-I      intronic chr19:42395544(+) A-I      intronic chr19:42395454(+) A-I      intronic chr19:42395616(+) A-I      intronic chr19:42405417(+) A-I      intronic chr19:42394876(+) A-I      intronic chr19:42404363(+) A-I      intronic chr19:42394531(+) A-I      intronic chr19:42395418(+) A-I      intronic chr19:42394594(+) A-I      intronic chr19:42395472(+) A-I      intronic chr19:42404989(+) A-I      intronic chr19:42394521(+) A-I      intronic chr19:42394302(+) A-I      intronic chr19:42395484(+) A-I      intronic chr19:42395494(+) A-I      intronic chr19:42394656(+) A-I      intronic chr19:42404453(+) A-I      intronic chr19:42394681(+) A-I      intronic chr19:42394882(+) A-I      intronic chr19:42395434(+) A-I      intronic chr19:42404377(+) A-I      intronic chr19:42395575(+) A-I      intronic chr19:42394687(+) A-I      intronic chr19:42404205(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ARHGEF1	chr19:42394730(+) A-I intron -    22327324 chr19:42395457(+) A-I intron -    21960545 chr19:42394302(+) A-G intron -    22484847 chr19:42394309(+) A-G intron -    22484847 chr19:42394492(+) A-G intron -    22484847 chr19:42394681(+) A-G intron -    22484847 chr19:42394730(+) A-G intron -    22484847 chr19:42394866(+) A-G intron -    22484847 chr19:42394882(+) A-G intron -    22484847 chr19:42395484(+) A-G intron -    22484847 chr19:42404336(+) A-G intron -    22484847 chr19:42404346(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ARHGEF1	chr19:42387289-42387290(+) m6A 5'UTR//exon       25456834//24981863//27371828 chr19:42387349-42387350(+) m6A 5'UTR//exon       24284625//25456834//24981863//27371828 chr19:42388450-42388451(+) m6A 5'UTR//intron       24284625//25456834//24981863//27371828 chr19:42392160-42392161(+) m6A CDS//exon//intron       24284625//24981863 chr19:42392346-42392347(+) m6A CDS//exon//intron       24284625 chr19:42392838-42392839(+) m6A CDS//exon//intron       24284625 chr19:42392929-42392930(+) m6A CDS//exon//intron       - chr19:42393179-42393180(+) m6A exon//intron       - chr19:42393218-42393219(+) m6A exon//intron       25456834 chr19:42393286-42393287(+) m6A exon//intron       25456834 chr19:42393296-42393297(+) m6A exon//intron       25456834 chr19:42393520-42393521(+) m6A exon//intron       24284625 chr19:42393539-42393540(+) m6A exon//intron       24284625 chr19:42393559-42393560(+) m6A exon//intron       24284625 chr19:42393618-42393619(+) m6A exon//intron       24284625//25456834//22575960 chr19:42393640-42393641(+) m6A exon//intron       24284625//25456834//24981863//22575960//22608085 chr19:42393670-42393671(+) m6A exon//intron       24284625//25456834//24981863//22575960//22608085 chr19:42393681-42393682(+) m6A exon//intron       24284625//25456834//24981863//22575960//22608085 chr19:42393706-42393707(+) m6A exon//intron       24284625//25456834//24981863//22575960//22608085 chr19:42393719-42393720(+) m6A exon//intron       24284625//25456834//24981863//22575960//22608085 chr19:42393732-42393733(+) m6A exon//intron       24284625//25456834//24981863//22608085 chr19:42393740-42393741(+) m6A exon//intron       24284625//25456834//24981863//22608085 chr19:42393784-42393785(+) m6A exon//intron       24284625//25456834//24981863//22608085 chr19:42393800-42393801(+) m6A exon//intron       24284625//25456834//22608085 chr19:42393827-42393828(+) m6A exon//intron       24284625//25456834 chr19:42393977-42393978(+) m6A exon//intron       25456834 chr19:42393991-42393992(+) m6A exon//intron       25456834 chr19:42394042-42394043(+) m6A exon//intron       25456834 chr19:42394406-42394407(+) m6A exon//intron       - chr19:42396772-42396773(+) m6A CDS//exon       - chr19:42396850-42396851(+) m6A CDS//exon       - chr19:42397296-42397297(+) m6A CDS//intron       - chr19:42397323-42397324(+) m6A 3'UTR//intron       - chr19:42397344-42397345(+) m6A 3'UTR//CDS//exon       22575960 chr19:42398331-42398332(+) m6A 3'UTR//CDS//exon       24209618//22575960 chr19:42398344-42398345(+) m6A 3'UTR//CDS//exon       24209618//22575960 chr19:42398362-42398363(+) m6A 3'UTR//CDS//exon       24209618//22575960 chr19:42398533-42398534(+) m6A 3'UTR//CDS//exon       24209618//22575960 chr19:42398559-42398560(+) m6A 3'UTR//CDS//exon       24209618//22575960 chr19:42398602-42398603(+) m6A 3'UTR//CDS//exon       - chr19:42399442-42399443(+) m6A 3'UTR//CDS//exon       - chr19:42399475-42399476(+) m6A CDS//exon       - chr19:42399502-42399503(+) m6A CDS//exon       - chr19:42399538-42399539(+) m6A CDS//exon       - chr19:42399547-42399548(+) m6A CDS//exon       - chr19:42399554-42399555(+) m6A CDS//exon       - chr19:42400476-42400477(+) m6A CDS//exon       - chr19:42400547-42400548(+) m6A CDS//exon       24981863 chr19:42402629-42402630(+) m6A CDS//exon       24981863 chr19:42402641-42402642(+) m6A CDS//exon       24981863 chr19:42402668-42402669(+) m6A CDS//exon       - chr19:42402682-42402683(+) m6A CDS//exon       - chr19:42406976-42406977(+) m6A CDS//exon       24981863 chr19:42407038-42407039(+) Cm CDS//exon       - chr19:42407042-42407043(+) m6A CDS//exon       24981863 chr19:42407868-42407869(+) m6A CDS//exon       - chr19:42407886-42407887(+) m6A CDS//exon       - chr19:42408193-42408194(+) m6A CDS//exon       - chr19:42408250-42408251(+) m6A CDS//exon       - chr19:42408450-42408451(+) m6A CDS//exon       - chr19:42408477-42408478(+) m6A CDS//exon       - chr19:42409168-42409169(+) m6A CDS//exon//intron       24284625 chr19:42409348-42409349(+) m6A CDS//exon//intron       24284625 chr19:42409920-42409921(+) m6A 3'UTR//CDS//exon       25456834 chr19:42410095-42410096(+) m6A 3'UTR//CDS//exon       24284625//25456834 chr19:42410133-42410134(+) m6A 3'UTR//CDS//exon       25456834 chr19:42410475-42410476(+) m6A exon//intron       - chr19:42410647-42410648(+) m6A CDS//exon//intron       - chr19:42410715-42410716(+) m6A CDS//exon//intron       - chr19:42410734-42410735(+) m6A CDS//exon//intron       - chr19:42410741-42410742(+) Cm CDS//exon//intron       - chr19:42410754-42410755(+) m6A CDS//exon//intron       - chr19:42411449-42411450(+) m6A 3'UTR//CDS//exon//intron       - chr19:42433954-42433955(+) m6A 3'UTR//exon       - chr19:42434001-42434002(+) m6A 3'UTR//exon       - chr19:42434028-42434029(+) m6A 3'UTR//exon       - chr19:42434098-42434099(+) m6A 3'UTR//exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	ARHGEF1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: ARHGEF1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).