Basic Information:

  VIRBase ID:  

HHID00004457

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          EIF3D:  NR_156418     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	EIF3D
miRBase Accession/Entrez ID	MIMAT0000458	8664
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	eIF3-p66//eIF3-zeta//EIF3S7

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	EIF3D	chr22:36909543(-) A-I      intronic chr22:36913989(-) A-I      intronic chr22:36913966(-) A-I      intronic chr22:36914498(-) A-I      intronic chr22:36909548(-) A-I      intronic chr22:36913968(-) A-I      intronic chr22:36913932(-) A-I      intronic chr22:36911513(-) A-I      intronic chr22:36911512(-) A-I      intronic chr22:36911492(-) A-I      intronic chr22:36911443(-) A-I      intronic chr22:36911435(-) A-I      intronic chr22:36911431(-) A-I      intronic chr22:36911393(-) A-I      intronic chr22:36909577(-) A-I      intronic chr22:36909525(-) A-I      intronic chr22:36909482(-) A-I      intronic chr22:36909446(-) A-I      intronic chr22:36909379(-) A-I      intronic chr22:36909354(-) A-I      intronic chr22:36913841(-) A-I      intronic chr22:36914333(-) A-I      intronic chr22:36913910(-) A-I      intronic chr22:36914009(-) A-I      intronic chr22:36913977(-) A-I      intronic chr22:36914020(-) A-I      intronic chr22:36914381(-) A-I      intronic chr22:36911573(-) A-I      intronic chr22:36914294(-) A-I      intronic chr22:36914067(-) A-I      intronic chr22:36913971(-) A-I      intronic chr22:36923631(-) A-I      intronic chr22:36913824(-) A-I      intronic chr22:36909582(-) A-I      intronic chr22:36914436(-) A-I      intronic chr22:36911488(-) A-I      intronic chr22:36914424(-) A-I      intronic chr22:36909870(-) A-I      intronic chr22:36914320(-) A-I      intronic chr22:36913906(-) A-I      intronic chr22:36911475(-) A-I      intronic chr22:36914388(-) A-I      intronic chr22:36913847(-) A-I      intronic chr22:36909862(-) A-I      intronic chr22:36914474(-) A-I      intronic chr22:36911319(-) A-I      intronic chr22:36911413(-) A-I      intronic chr22:36911331(-) A-I      intronic chr22:36913919(-) A-I      intronic chr22:36913972(-) A-I      intronic chr22:36909631(-) A-I      intronic chr22:36914522(-) A-I      intronic chr22:36913825(-) A-I      intronic chr22:36914458(-) A-I      intronic chr22:36922769(-) A-I      intronic chr22:36913965(-) A-I      intronic chr22:36911572(-) A-I      intronic chr22:36913963(-) A-I      intronic chr22:36914370(-) A-I      intronic chr22:36909452(-) A-I      intronic chr22:36914414(-) A-I      intronic chr22:36911372(-) A-I      intronic chr22:36914453(-) A-I      intronic chr22:36913973(-) A-I      intronic chr22:36909532(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	EIF3D	chr22:36913825(-) A-I intron -    22327324 chr22:36913974(-) A-I intron -    22327324 chr22:36913977(-) A-I intron -    22327324 chr22:36914381(-) A-I intron -    22327324 chr22:36914522(-) A-I intron -    22327324 chr22:36909792(-) A-G intron -    22484847 chr22:36911572(-) A-G intron -    22484847 chr22:36911573(-) A-G intron -    22484847 chr22:36913825(-) A-G intron -    22484847 chr22:36913965(-) A-G intron -    22484847 chr22:36913971(-) A-G intron -    22484847 chr22:36913972(-) A-G intron -    22484847 chr22:36913973(-) A-G intron -    22484847 chr22:36913974(-) A-G intron -    22484847 chr22:36913977(-) A-G intron -    22484847 chr22:36914020(-) A-G intron -    22484847 chr22:36914381(-) A-G intron -    22484847 chr22:36914436(-) A-G intron -    22484847 chr22:36914522(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	EIF3D	chr22:36906994-36906995(-) m6A 3'UTR//exon       - chr22:36907032-36907033(-) m6A 3'UTR//exon       - chr22:36907038-36907039(-) m6A 3'UTR//CDS//exon       - chr22:36907099-36907100(-) m6A 3'UTR//intron       - chr22:36907139-36907140(-) m6A 3'UTR//intron       - chr22:36907650-36907651(-) m6A CDS//exon       27773535//22575960 chr22:36907806-36907807(-) m6A 3'UTR//CDS//exon       22575960 chr22:36908614-36908615(-) m6A 3'UTR//CDS//exon       22575960 chr22:36912939-36912940(-) m6A exon//intron       26404942 chr22:36913457-36913458(-) m6A 3'UTR//CDS       26404942//27773535 chr22:36913477-36913478(-) m6A CDS       27773535 chr22:36914823-36914824(-) m6A CDS       27773535 chr22:36914843-36914844(-) m6A CDS       27773535 chr22:36914947-36914948(-) m6A CDS       27773535 chr22:36916625-36916626(-) m6A CDS       26404942//27773535 chr22:36916724-36916725(-) m6A CDS       27773535 chr22:36916732-36916733(-) m6A CDS       24981863//27773535 chr22:36919294-36919295(-) m6A CDS//exon       24981863//27773535//22575960 chr22:36919952-36919953(-) m6A CDS//exon       24981863//26404942//27773535//22575960 chr22:36919995-36919996(-) m6A CDS//exon       24981863//26404942//27773535//22575960 chr22:36920010-36920011(-) m6A CDS//exon       24981863//26404942//27773535//22575960 chr22:36920022-36920023(-) m6A CDS//exon       24981863//26404942//27773535//22575960 chr22:36921727-36921728(-) Am CDS//exon       - chr22:36921743-36921744(-) m6A CDS//exon       27773535 chr22:36921748-36921749(-) m6A CDS//exon       27773535 chr22:36921804-36921805(-) m6A exon//intron       - chr22:36921853-36921854(-) m6A exon//intron       - chr22:36921865-36921866(-) m6A exon//intron       - chr22:36922136-36922137(-) m6A CDS//exon       24981863//27773535 chr22:36922942-36922943(-) m6A 5'UTR//intron       24981863 chr22:36924805-36924806(-) m6A 5'UTR//intron       24981863 chr22:36925037-36925038(-) m6A 5'UTR//intron       24981863 chr22:36925072-36925073(-) m6A 5'UTR//intron       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	EIF3D	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: EIF3D

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).