Basic Information:

  VIRBase ID:  

HHID00004443

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          CNTNAP1:  NM_003632     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	CNTNAP1
miRBase Accession/Entrez ID	MIMAT0000458	8506
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CASPR//CHN3//CNTNAP//NRXN4//P190

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CNTNAP1	chr17:40837701(+) A-I      intronic chr17:40848937(+) A-I      intronic chr17:40848930(+) A-I      intronic chr17:40848503(+) A-I      intronic chr17:40848422(+) A-I      intronic chr17:40848442(+) A-I      intronic chr17:40848411(+) A-I      intronic chr17:40848421(+) A-I      intronic chr17:40848717(+) A-I      intronic chr17:40848784(+) A-I      intronic chr17:40848800(+) A-I      intronic chr17:40848982(+) A-I      intronic chr17:40848367(+) A-I      intronic chr17:40846412(+) A-I      intronic chr17:40845861(+) A-I      intronic chr17:40848765(+) A-I      intronic chr17:40846347(+) A-I      intronic chr17:40846563(+) A-I      intronic chr17:40848713(+) A-I      intronic chr17:40848550(+) A-I      intronic chr17:40848617(+) A-I      intronic chr17:40846294(+) A-I      intronic chr17:40845825(+) A-I      intronic chr17:40845854(+) A-I      intronic chr17:40845963(+) A-I      intronic chr17:40848914(+) A-I      intronic chr17:40845839(+) A-I      intronic chr17:40842426(+) A-I      intronic chr17:40848588(+) A-I      intronic chr17:40845856(+) A-I      intronic chr17:40845902(+) A-I      intronic chr17:40845996(+) A-I      intronic chr17:40845807(+) A-I      intronic chr17:40846503(+) A-I      intronic chr17:40846387(+) A-I      intronic chr17:40846654(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CNTNAP1	chr17:40846532(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CNTNAP1	chr17:40834642-40834643(+) m6A 5'UTR       24209618//25456834//24981863 chr17:40834649-40834650(+) m6A 5'UTR       24209618//25456834//24981863 chr17:40834684-40834685(+) m6A 5'UTR       24209618//25456834//24981863 chr17:40834755-40834756(+) m6A 5'UTR       24209618//25456834//24981863 chr17:40834788-40834789(+) m6A 5'UTR       24209618//24981863 chr17:40834833-40834834(+) m6A 5'UTR       24209618//24981863 chr17:40839870-40839871(+) m6A CDS//exon       27371828 chr17:40851093-40851094(+) m6A 3'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	CNTNAP1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: CNTNAP1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).