Detail Information

Basic Information:


  VIRBase ID:  

HHID00004401

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:           ZNF180:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-5p ZNF180
miRBase
Accession/Entrez ID		 MIMAT0000458 7733
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - HHZ168

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-5p
rs1018706777 chr15:62823984    A/G
rs1369926402 chr15:62823991    G/A
rs1555521311 chr15:62823990    G/C
rs755866868 chr15:62823986    A/G
rs766742872 chr15:62823990    GGTT/G
rs777464613 chr15:62823987    T/G
rs1228899174 chr15:62823974    T/A
rs1281303771 chr15:62823976    T/C
rs1350000299 chr15:62823972    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ZNF180
chr19:44981058(-) A-I      NonSyn:Lys->Arg
chr19:44981059(-) A-I      NonSyn:Lys->Glu
chr19:44981068(-) A-I      NonSyn:Thr->Ala
chr19:44981063(-) A-I      Syn:Gly->Gly
chr19:44981078(-) A-I      Syn:Gln->Gln
chr19:45000220(-) A-I      intronic
chr19:45000234(-) A-I      intronic
chr19:45000239(-) A-I      intronic
chr19:44995754(-) A-I      intronic
chr19:44998589(-) A-I      intronic
chr19:45000212(-) A-I      intronic
chr19:44995719(-) A-I      intronic
chr19:44995725(-) A-I      intronic
chr19:44995782(-) A-I      intronic
chr19:44995786(-) A-I      intronic
chr19:44995790(-) A-I      intronic
chr19:45000208(-) A-I      intronic
chr19:45000218(-) A-I      intronic
chr19:44995760(-) A-I      intronic
chr19:44991062(-) A-I      intronic
chr19:44994304(-) A-I      intronic
chr19:44998521(-) A-I      intronic
chr19:44998576(-) A-I      intronic
chr19:45000279(-) A-I      intronic
chr19:45000293(-) A-I      intronic
chr19:45000307(-) A-I      intronic
chr19:44992207(-) A-I      intronic
chr19:44991145(-) A-I      intronic
chr19:44991146(-) A-I      intronic
chr19:44992004(-) A-I      intronic
chr19:44992048(-) A-I      intronic
chr19:44992065(-) A-I      intronic
chr19:44991029(-) A-I      intronic
chr19:44991059(-) A-I      intronic
chr19:44992119(-) A-I      intronic
chr19:45000534(-) A-I      intronic
chr19:45000510(-) A-I      intronic
chr19:45000496(-) A-I      intronic
chr19:44991142(-) A-I      intronic
chr19:44991172(-) A-I      intronic
chr19:45000115(-) A-I      intronic
chr19:45000557(-) A-I      intronic
chr19:44990934(-) A-I      intronic
chr19:44990879(-) A-I      intronic
chr19:44992061(-) A-I      intronic
chr19:44984530(-) A-I      intronic
chr19:44998611(-) A-I      intronic
chr19:44990896(-) A-I      intronic
chr19:44986397(-) A-I      intronic
chr19:44988378(-) A-I      intronic
chr19:44984531(-) A-I      intronic
chr19:45000561(-) A-I      intronic
chr19:45000560(-) A-I      intronic
chr19:44986403(-) A-I      intronic
chr19:44986298(-) A-I      intronic
chr19:44990994(-) A-I      intronic
chr19:44991007(-) A-I      intronic
chr19:44991085(-) A-I      intronic
chr19:44995695(-) A-I      intronic
chr19:44986504(-) A-I      intronic
chr19:44991068(-) A-I      intronic
chr19:44986425(-) A-I      intronic
chr19:44992202(-) A-I      intronic
chr19:45000509(-) A-I      intronic
chr19:45000153(-) A-I      intronic
chr19:44984595(-) A-I      intronic
chr19:45000463(-) A-I      intronic
chr19:44992163(-) A-I      intronic
chr19:45000479(-) A-I      intronic
chr19:44995733(-) A-I      intronic
chr19:44988414(-) A-I      intronic
chr19:44991303(-) A-I      intronic
chr19:44986413(-) A-I      intronic
chr19:44986487(-) A-I      intronic
chr19:44986332(-) A-I      intronic
chr19:45000545(-) A-I      intronic
chr19:44998698(-) A-I      intronic
chr19:45000355(-) A-I      intronic
chr19:44992130(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ZNF180
chr19:44986341(-) A-G intron -    22484847
chr19:44995695(-) A-G intron -    22484847
chr19:45000479(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZNF180
chr19:44978686-44978687(-) m6A 3'UTR       27773535
chr19:44978820-44978821(-) m6A 3'UTR       27773535
chr19:44980401-44980402(-) m6A 3'UTR       27773535
chr19:44980506-44980507(-) m6A 3'UTR       27773535//22608085
chr19:44980523-44980524(-) m6A 3'UTR       27773535//22608085
chr19:44980535-44980536(-) m6A 3'UTR       27773535//22608085
chr19:44980636-44980637(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr19:44980672-44980673(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr19:44980720-44980721(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr19:44980737-44980738(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr19:44980776-44980777(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr19:44980804-44980805(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr19:44980821-44980822(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr19:44980852-44980853(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr19:44980905-44980906(-) m6A 3'UTR//CDS       24981863//27773535//22608085
chr19:44980972-44980973(-) m6A 3'UTR//CDS       24981863//27773535//22608085
chr19:44981056-44981057(-) m6A 3'UTR//CDS       24981863//27773535//22608085
chr19:44981073-44981074(-) m6A 3'UTR//CDS       24981863//27773535//22608085
chr19:44981140-44981141(-) m6A 3'UTR//CDS       24209618//25456834//24981863//27773535//22608085
chr19:44981157-44981158(-) m6A 3'UTR//CDS       24209618//25456834//24981863//27773535//22608085
chr19:44981176-44981177(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22608085
chr19:44981224-44981225(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr19:44981260-44981261(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr19:44981325-44981326(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr19:44981344-44981345(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr19:44981409-44981410(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr19:44981476-44981477(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr19:44981493-44981494(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr19:44981560-44981561(-) m6A 3'UTR//CDS       24284625//25456834//24981863//27773535//22608085
chr19:44981577-44981578(-) m6A 3'UTR//CDS       24284625//25456834//24981863//27773535//22608085
chr19:44981644-44981645(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr19:44981669-44981670(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr19:44981697-44981698(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr19:44981743-44981744(-) m6A 3'UTR//CDS       24981863//27773535//22608085
chr19:44981765-44981766(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr19:44981799-44981800(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr19:44981895-44981896(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr19:44981901-44981902(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr19:44981938-44981939(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr19:44981967-44981968(-) m6A 3'UTR//CDS       24981863//27773535//22608085
chr19:44981996-44981997(-) m6A 3'UTR//CDS       24981863//27773535//22608085
chr19:44982040-44982041(-) m6A 3'UTR//CDS       24981863//27773535//22608085
chr19:44982053-44982054(-) m6A 3'UTR//CDS       24981863//27773535//22608085
chr19:44982114-44982115(-) m6A 3'UTR//CDS       24981863//27773535//22608085
chr19:44982193-44982194(-) m6A 3'UTR//CDS       24981863//27773535//22608085
chr19:44982218-44982219(-) m6A 3'UTR//CDS       24981863//27773535//22608085
chr19:44988872-44988873(-) m6A 3'UTR//intron       -
chr19:44988882-44988883(-) m6A 3'UTR//intron       -
chr19:45001417-45001418(-) m6A 5'UTR//CDS//exon       27371828//27773536
chr19:45004463-45004464(-) m6A 5'UTR//exon       24981863//27371828//27773536
chr19:45004468-45004469(-) m6A 5'UTR//exon       24981863//27371828//27773536
chr19:45004511-45004512(-) m6A 5'UTR//exon       24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-5p
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
ZNF180
Cytosol K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-5p
Interactor2: ZNF180

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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