Basic Information:

  VIRBase ID:  

HHID00004387

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          VEGFA:  NM_001171622     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	VEGFA
miRBase Accession/Entrez ID	MIMAT0000458	7422
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	MVCD1//VEGF//VPF

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	VEGFA	chr6:43738036-43738037(+) m6A 5'UTR//exon       24981863 chr6:43738048-43738049(+) m6A 5'UTR//exon       24981863 chr6:43738124-43738125(+) m6A 5'UTR//exon       24981863 chr6:43738139-43738140(+) m6A 5'UTR//exon       24284625 chr6:43738249-43738250(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr6:43738450-43738451(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr6:43738458-43738459(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr6:43738509-43738510(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr6:43738601-43738602(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr6:43738738-43738739(+) m1A 5'UTR//CDS//exon       26863196//26863410 chr6:43738825-43738826(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr6:43738980-43738981(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960 chr6:43738987-43738988(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960 chr6:43741786-43741787(+) m6A exon//intron       - chr6:43745461-43745462(+) m6A exon//intron       27773535 chr6:43745833-43745834(+) m6A exon//intron       - chr6:43745926-43745927(+) m6A exon//intron       - chr6:43746210-43746211(+) m6A CDS//exon//intron       24284625//24209618 chr6:43746477-43746478(+) m6A exon//intron       24981863 chr6:43746646-43746647(+) m6A CDS//exon//intron       24981863 chr6:43746762-43746763(+) m6A exon//intron       24981863 chr6:43747745-43747746(+) m6A exon//intron       - chr6:43748323-43748324(+) m6A exon//intron       - chr6:43749769-43749770(+) m6A CDS//exon//intron       24284625 chr6:43749775-43749776(+) m6A CDS//exon//intron       24284625 chr6:43752338-43752339(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr6:43752360-43752361(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr6:43752386-43752387(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr6:43752423-43752424(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr6:43752441-43752442(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43752463-43752464(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43752498-43752499(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr6:43752632-43752633(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr6:43752790-43752791(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43752852-43752853(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43752961-43752962(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43752971-43752972(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43753013-43753014(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43753021-43753022(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43753022-43753023(+) Cm 3'UTR//exon       - chr6:43753046-43753047(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43753082-43753083(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:43753211-43753212(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr6:43753243-43753244(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr6:43753288-43753289(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr6:43753339-43753340(+) m6A 3'UTR//exon       24284625//24209618//24981863//22575960//22608085 chr6:43753362-43753363(+) m6A 3'UTR//exon       24284625//24209618//24981863//22575960//22608085 chr6:43753387-43753388(+) m6A 3'UTR//exon       24284625//24209618//24981863//22575960//22608085 chr6:43753464-43753465(+) m6A 3'UTR//exon       24284625//24209618//22575960 chr6:43753562-43753563(+) m6A 3'UTR//exon       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	VEGFA	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Endoplasmic reticulum Human fibrosarcoma cells (HT1080)     25753659 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HeLa cells     25063809

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: VEGFA

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).