Detail Information

Basic Information:


  VIRBase ID:  

HHID00004328

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:           SNCA:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-5p SNCA
miRBase
Accession/Entrez ID		 MIMAT0000458 6622
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - NACP//PARK1//PARK4//PD1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-5p
rs1018706777 chr15:62823984    A/G
rs1369926402 chr15:62823991    G/A
rs1555521311 chr15:62823990    G/C
rs755866868 chr15:62823986    A/G
rs766742872 chr15:62823990    GGTT/G
rs777464613 chr15:62823987    T/G
rs1228899174 chr15:62823974    T/A
rs1281303771 chr15:62823976    T/C
rs1350000299 chr15:62823972    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SNCA
chr4:90685699(-) A-I      intronic
chr4:90717343(-) A-I      intronic
chr4:90653275(-) A-I      intronic
chr4:90651009(-) A-I      intronic
chr4:90716665(-) A-I      intronic
chr4:90686577(-) A-I      intronic
chr4:90688885(-) A-I      intronic
chr4:90716726(-) A-I      intronic
chr4:90716702(-) A-I      intronic
chr4:90686497(-) A-I      intronic
chr4:90716789(-) A-I      intronic
chr4:90686579(-) A-I      intronic
chr4:90653214(-) A-I      intronic
chr4:90651002(-) A-I      intronic
chr4:90717364(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SNCA
chr4:90647057-90647058(-) m6A 3'UTR       22608085
chr4:90647125-90647126(-) m6A 3'UTR       22608085
chr4:90647138-90647139(-) m6A 3'UTR       22608085
chr4:90743461-90743462(-) m6A CDS       24209618
chr4:90743527-90743528(-) m6A CDS       24209618
chr4:90749326-90749327(-) m6A CDS//intron       24209618
chr4:90756721-90756722(-) m6A CDS       24209618
chr4:90756749-90756750(-) m6A CDS       -
chr4:90756754-90756755(-) m6A CDS       -
chr4:90756797-90756798(-) m6A CDS       -
chr4:90757288-90757289(-) m6A 5'UTR//intron       -
chr4:90757325-90757326(-) m6A 5'UTR//intron       -
chr4:90757898-90757899(-) m6A 5'UTR//intron       -
chr4:90758136-90758137(-) m6A 5'UTR//intron       24209618//27773536
chr4:90758225-90758226(-) m6A 5'UTR//intron       24209618//25456834//24981863//27773536
chr4:90758328-90758329(-) m6A 5'UTR//intron       25456834//24981863
chr4:90759427-90759428(-) m6A 5'UTR       25456834

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-5p
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
SNCA
Cytosol HeLa-S3 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-5p
Interactor2: SNCA

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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