Basic Information:

  VIRBase ID:  

HHID00004293

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          RFXAP:  NM_000538     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	RFXAP
miRBase Accession/Entrez ID	MIMAT0000458	5994
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RFXAP	chr13:37402482(+) A-I      3'UTR chr13:37402475(+) A-I      3'UTR chr13:37402490(+) A-I      3'UTR chr13:37402483(+) A-I      3'UTR chr13:37395543(+) A-I      intronic chr13:37395764(+) A-I      intronic chr13:37396364(+) A-I      intronic chr13:37400105(+) A-I      intronic chr13:37396345(+) A-I      intronic chr13:37396302(+) A-I      intronic chr13:37396245(+) A-I      intronic chr13:37395616(+) A-I      intronic chr13:37395565(+) A-I      intronic chr13:37396822(+) A-I      intronic chr13:37396369(+) A-I      intronic chr13:37395744(+) A-I      intronic chr13:37400346(+) A-I      intronic chr13:37396305(+) A-I      intronic chr13:37395252(+) A-I      intronic chr13:37395689(+) A-I      intronic chr13:37395724(+) A-I      intronic chr13:37395536(+) A-I      intronic chr13:37395368(+) A-I      intronic chr13:37395740(+) A-I      intronic chr13:37396357(+) A-I      intronic chr13:37395653(+) A-I      intronic chr13:37395259(+) A-I      intronic chr13:37395217(+) A-I      intronic chr13:37395542(+) A-I      intronic chr13:37396257(+) A-I      intronic chr13:37396308(+) A-I      intronic chr13:37400189(+) A-I      intronic chr13:37395294(+) A-I      intronic chr13:37395208(+) A-I      intronic chr13:37395669(+) A-I      intronic chr13:37395274(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RFXAP	chr13:37393765-37393766(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr13:37393774-37393775(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr13:37393783-37393784(+) m6A CDS       24284625//25456834//24981863//22608085 chr13:37393839-37393840(+) m6A CDS       24284625//25456834//24981863//22608085 chr13:37393911-37393912(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr13:37393938-37393939(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr13:37393967-37393968(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr13:37393985-37393986(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr13:37394008-37394009(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr13:37394025-37394026(+) m1A CDS       26863196 chr13:37394044-37394045(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr13:37394055-37394056(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr13:37394087-37394088(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr13:37399596-37399597(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22608085 chr13:37399603-37399604(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22608085 chr13:37399632-37399633(+) m6A CDS//exon       24284625//24209618//24981863//22608085 chr13:37399647-37399648(+) m6A CDS//exon       24284625//24209618//24981863//22608085 chr13:37399668-37399669(+) m6A CDS//exon       24284625//24981863//22608085 chr13:37401820-37401821(+) m6A CDS//exon       24284625//24981863//22608085 chr13:37401859-37401860(+) m6A CDS//exon       24284625//24981863//22608085 chr13:37401878-37401879(+) m6A CDS//exon       24284625//24981863//22608085 chr13:37401894-37401895(+) m6A 3'UTR//intron       24981863//22608085 chr13:37401905-37401906(+) m6A 3'UTR//intron       24981863//22608085 chr13:37401959-37401960(+) m6A 3'UTR//intron       22608085 chr13:37401991-37401992(+) m6A 3'UTR//intron       22608085 chr13:37401997-37401998(+) m6A 3'UTR//intron       22608085 chr13:37402568-37402569(+) Y 3'UTR//intron       26075521

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	RFXAP	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: RFXAP

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).