Detail Information

Basic Information:


  VIRBase ID:  

HHID00004249

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:           PLAG1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-5p PLAG1
miRBase
Accession/Entrez ID		 MIMAT0000458 5324
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - PSA//SGPA//SRS4//ZNF912

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-5p
rs1018706777 chr15:62823984    A/G
rs1369926402 chr15:62823991    G/A
rs1555521311 chr15:62823990    G/C
rs755866868 chr15:62823986    A/G
rs766742872 chr15:62823990    GGTT/G
rs777464613 chr15:62823987    T/G
rs1228899174 chr15:62823974    T/A
rs1281303771 chr15:62823976    T/C
rs1350000299 chr15:62823972    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PLAG1
chr8:57097328(-) A-I      intronic
chr8:57097359(-) A-I      intronic
chr8:57097364(-) A-I      intronic
chr8:57097480(-) A-I      intronic
chr8:57099378(-) A-I      intronic
chr8:57099404(-) A-I      intronic
chr8:57106448(-) A-I      intronic
chr8:57106718(-) A-I      intronic
chr8:57106741(-) A-I      intronic
chr8:57088773(-) A-I      intronic
chr8:57088778(-) A-I      intronic
chr8:57088811(-) A-I      intronic
chr8:57088839(-) A-I      intronic
chr8:57097313(-) A-I      intronic
chr8:57099151(-) A-I      intronic
chr8:57106429(-) A-I      intronic
chr8:57106322(-) A-I      intronic
chr8:57106396(-) A-I      intronic
chr8:57106446(-) A-I      intronic
chr8:57099028(-) A-I      intronic
chr8:57097462(-) A-I      intronic
chr8:57097296(-) A-I      intronic
chr8:57097202(-) A-I      intronic
chr8:57106447(-) A-I      intronic
chr8:57106794(-) A-I      intronic
chr8:57097468(-) A-I      intronic
chr8:57106754(-) A-I      intronic
chr8:57099207(-) A-I      intronic
chr8:57106705(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PLAG1
chr8:57097202(-) A-G intron -    22484847
chr8:57097462(-) A-G intron -    22484847
chr8:57097468(-) A-G intron -    22484847
chr8:57106446(-) A-G intron -    22484847
chr8:57106447(-) A-G intron -    22484847
chr8:57106793(-) A-G intron -    22484847
chr8:57106794(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PLAG1
chr8:57073622-57073623(-) m6A 3'UTR       27773535
chr8:57073644-57073645(-) m6A 3'UTR       27773535
chr8:57073726-57073727(-) m6A 3'UTR       27773535
chr8:57073754-57073755(-) m6A 3'UTR       27773535
chr8:57073929-57073930(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr8:57073970-57073971(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr8:57073981-57073982(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr8:57074020-57074021(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr8:57074061-57074062(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//22608085
chr8:57074139-57074140(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085
chr8:57074158-57074159(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085
chr8:57074210-57074211(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr8:57074273-57074274(-) m6A 3'UTR       27773535//22608085
chr8:57079069-57079070(-) m6A CDS//exon       27773535
chr8:57079114-57079115(-) m6A CDS//exon       24284625//27773535
chr8:57079257-57079258(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085
chr8:57079339-57079340(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085
chr8:57079438-57079439(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085
chr8:57079453-57079454(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085
chr8:57079476-57079477(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22608085
chr8:57079566-57079567(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr8:57079571-57079572(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr8:57079669-57079670(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr8:57079698-57079699(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr8:57079740-57079741(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr8:57079832-57079833(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr8:57079918-57079919(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr8:57080033-57080034(-) m6A CDS//exon       24284625//24981863//27773535//22608085
chr8:57080625-57080626(-) m6A CDS//exon//intron       22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-5p
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
PLAG1
Chromatin K562 cells     -
Cytosol HeLa-S3 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-5p
Interactor2: PLAG1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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