Basic Information:

  VIRBase ID:  

HHID00004246

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          PIK3CG:  NM_002649     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	PIK3CG
miRBase Accession/Entrez ID	MIMAT0000458	5294
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	p110gamma//p120-PI3K//PI3CG//PI3K//PI3Kgamma//PIK3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PIK3CG	chr7:106521177(+) A-I      intronic chr7:106521175(+) A-I      intronic chr7:106522298(+) A-I      intronic chr7:106522108(+) A-I      intronic chr7:106522037(+) A-I      intronic chr7:106521227(+) A-I      intronic chr7:106517396(+) A-I      intronic chr7:106517442(+) A-I      intronic chr7:106517457(+) A-I      intronic chr7:106521250(+) A-I      intronic chr7:106522106(+) A-I      intronic chr7:106521257(+) A-I      intronic chr7:106522215(+) A-I      intronic chr7:106521160(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PIK3CG	chr7:106516354(+) G-T intron -    22484847 chr7:106521250(+) A-G intron -    22484847 chr7:106521257(+) A-G intron -    22484847 chr7:106521326(+) A-G intron -    22484847 chr7:106522106(+) A-G intron -    22484847 chr7:106522215(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PIK3CG	chr7:106508246-106508247(+) m6A CDS//intron       - chr7:106508262-106508263(+) m6A CDS//intron       - chr7:106508281-106508282(+) m6A CDS//intron       - chr7:106508357-106508358(+) m6A CDS//intron       - chr7:106508364-106508365(+) m6A CDS//intron       - chr7:106508806-106508807(+) m6A CDS//intron       - chr7:106508871-106508872(+) m6A CDS//intron       25456834 chr7:106508928-106508929(+) m6A CDS//intron       25456834 chr7:106508940-106508941(+) m6A CDS//intron       25456834 chr7:106509039-106509040(+) m6A CDS//intron       - chr7:106509072-106509073(+) m6A CDS//intron       - chr7:106509132-106509133(+) m6A CDS//intron       - chr7:106509162-106509163(+) m6A CDS//intron       - chr7:106509483-106509484(+) m6A CDS//intron       - chr7:106509508-106509509(+) m6A CDS//intron       - chr7:106509531-106509532(+) m6A CDS//intron       - chr7:106509540-106509541(+) m6A CDS//intron       - chr7:106509567-106509568(+) m6A CDS//intron       - chr7:106509627-106509628(+) m6A CDS//intron       - chr7:106509717-106509718(+) m6A CDS//intron       - chr7:106509802-106509803(+) m6A CDS//intron       - chr7:106509824-106509825(+) m6A CDS//intron       - chr7:106509900-106509901(+) m6A CDS//intron       - chr7:106509946-106509947(+) m6A CDS//intron       - chr7:106545807-106545808(+) m6A CDS       - chr7:106545819-106545820(+) m6A CDS       - chr7:106545853-106545854(+) m6A 3'UTR       - chr7:106545897-106545898(+) m6A 3'UTR       - chr7:106545919-106545920(+) m6A 3'UTR       - chr7:106545967-106545968(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	PIK3CG	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: PIK3CG

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).