Detail Information

Basic Information:


  VIRBase ID:  

HHID00004229

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:           SERPINE1:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-5p SERPINE1
miRBase
Accession/Entrez ID		 MIMAT0000458 5054
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - PAI//PAI-1//PAI1//PLANH1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-5p
rs1018706777 chr15:62823984    A/G
rs1369926402 chr15:62823991    G/A
rs1555521311 chr15:62823990    G/C
rs755866868 chr15:62823986    A/G
rs766742872 chr15:62823990    GGTT/G
rs777464613 chr15:62823987    T/G
rs1228899174 chr15:62823974    T/A
rs1281303771 chr15:62823976    T/C
rs1350000299 chr15:62823972    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SERPINE1
chr7:100776020(+) A-I      intronic
chr7:100776467(+) A-I      intronic
chr7:100776495(+) A-I      intronic
chr7:100776023(+) A-I      intronic
chr7:100776025(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SERPINE1
chr7:100770426-100770427(+) m6A 5'UTR       24284625//24981863//26404942
chr7:100770491-100770492(+) m6A 5'UTR       24284625//24981863//26404942
chr7:100770518-100770519(+) m6A 5'UTR       24284625//26404942
chr7:100771902-100771903(+) m6A CDS       26404942
chr7:100773758-100773759(+) m6A CDS       26404942
chr7:100773872-100773873(+) m6A CDS       26404942
chr7:100773922-100773923(+) m6A CDS       26404942
chr7:100775191-100775192(+) m6A CDS       26404942
chr7:100775247-100775248(+) m6A CDS       26404942
chr7:100779036-100779037(+) Am CDS       -
chr7:100780326-100780327(+) m6A CDS       24284625//24209618//26404942//27773535
chr7:100780687-100780688(+) m6A CDS       24284625//24209618//24981863//26404942//27773535
chr7:100780716-100780717(+) m6A CDS       24284625//24209618//24981863//26404942//27773535
chr7:100780750-100780751(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535
chr7:100780755-100780756(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535
chr7:100780781-100780782(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535
chr7:100780833-100780834(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535
chr7:100780861-100780862(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535
chr7:100780879-100780880(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535
chr7:100780900-100780901(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535
chr7:100780913-100780914(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535
chr7:100780934-100780935(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535
chr7:100780979-100780980(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535
chr7:100781001-100781002(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942
chr7:100781053-100781054(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942
chr7:100781087-100781088(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942
chr7:100781126-100781127(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942
chr7:100781216-100781217(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942
chr7:100781348-100781349(+) m6A 3'UTR       24284625
chr7:100781659-100781660(+) m6A 3'UTR       24981863
chr7:100781706-100781707(+) m6A 3'UTR       24981863//26404942
chr7:100781802-100781803(+) m6A 3'UTR       24981863//26404942
chr7:100781808-100781809(+) m6A 3'UTR       24981863//26404942
chr7:100781820-100781821(+) m6A 3'UTR       24981863//26404942
chr7:100781889-100781890(+) m6A 3'UTR       24981863//26404942
chr7:100781894-100781895(+) m6A 3'UTR       24981863//26404942
chr7:100781979-100781980(+) m6A 3'UTR       24284625//26404942
chr7:100782007-100782008(+) m6A 3'UTR       24284625//26404942
chr7:100782050-100782051(+) m6A 3'UTR       24284625//26404942
chr7:100782140-100782141(+) m6A 3'UTR       26404942
chr7:100782163-100782164(+) m6A 3'UTR       26404942
chr7:100782250-100782251(+) m6A 3'UTR       26404942

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-5p
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
SERPINE1
Cytosol HCC cell line (HepG2)|HeLa-S3 cells     -
ER-bound ribosome Cutaneous T-cell lymphoma cell lines (HuT78|SeAx)     19175411
Exosome Blood     -
Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-5p
Interactor2: SERPINE1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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