Basic Information:

  VIRBase ID:  

HHID00004107

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          GCLM:  NM_001308253     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	GCLM
miRBase Accession/Entrez ID	MIMAT0000458	2730
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	GLCLR

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GCLM	chr1:94352719(-) A-I      3'UTR chr1:94352726(-) A-I      3'UTR chr1:94352688(-) A-I      3'UTR chr1:94352727(-) A-I      3'UTR chr1:94352730(-) A-I      3'UTR chr1:94352744(-) A-I      3'UTR chr1:94364433(-) A-I      intronic chr1:94356722(-) A-I      intronic chr1:94359745(-) A-I      intronic chr1:94370677(-) A-I      intronic chr1:94355605(-) A-I      intronic chr1:94356557(-) A-I      intronic chr1:94356643(-) A-I      intronic chr1:94356715(-) A-I      intronic chr1:94356694(-) A-I      intronic chr1:94359622(-) A-I      intronic chr1:94355536(-) A-I      intronic chr1:94356652(-) A-I      intronic chr1:94353165(-) A-I      3'UTR chr1:94359771(-) A-I      intronic chr1:94364727(-) A-I      intronic chr1:94359626(-) A-I      intronic chr1:94359714(-) A-I      intronic chr1:94359774(-) A-I      intronic chr1:94367863(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	GCLM	chr1:94353224(-) G-A exon 3'UTR    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GCLM	chr1:94350762-94350763(-) m6A 3'UTR       27773535 chr1:94350799-94350800(-) m6A 3'UTR       27773535 chr1:94350805-94350806(-) m6A 3'UTR       27773535 chr1:94350814-94350815(-) m6A 3'UTR       27773535 chr1:94351822-94351823(-) m6A 3'UTR       26404942 chr1:94351888-94351889(-) m6A 3'UTR       26404942 chr1:94351948-94351949(-) m6A 3'UTR       26404942 chr1:94352215-94352216(-) m6A 3'UTR       26404942 chr1:94352237-94352238(-) m6A 3'UTR       26404942 chr1:94352290-94352291(-) m6A 3'UTR       26404942 chr1:94353348-94353349(-) m6A 3'UTR       27773535 chr1:94353415-94353416(-) m6A 3'UTR       27773535 chr1:94353445-94353446(-) m6A 3'UTR       27773535 chr1:94353486-94353487(-) m6A 3'UTR       27773535 chr1:94353556-94353557(-) m6A 3'UTR       24981863//26404942 chr1:94353619-94353620(-) m6A 3'UTR       24981863//26404942 chr1:94354668-94354669(-) Y CDS       26075521 chr1:94360278-94360279(-) m6A CDS//exon       26404942 chr1:94362194-94362195(-) m6A CDS//exon       26404942 chr1:94362205-94362206(-) m6A CDS//exon       26404942 chr1:94362210-94362211(-) m6A CDS//exon       26404942 chr1:94362258-94362259(-) m6A CDS//exon       26404942 chr1:94374865-94374866(-) m6A 5'UTR       24209618//24981863//22575960 chr1:94374996-94374997(-) m6A 5'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	GCLM	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: GCLM

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).