Detail Information

Basic Information:


  VIRBase ID:  

HHID00004006

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:           CA8:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-5p CA8
miRBase
Accession/Entrez ID		 MIMAT0000458 767
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CA-RP//CA-VIII//CALS//CAMRQ3//CARP

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-5p
rs1018706777 chr15:62823984    A/G
rs1369926402 chr15:62823991    G/A
rs1555521311 chr15:62823990    G/C
rs755866868 chr15:62823986    A/G
rs766742872 chr15:62823990    GGTT/G
rs777464613 chr15:62823987    T/G
rs1228899174 chr15:62823974    T/A
rs1281303771 chr15:62823976    T/C
rs1350000299 chr15:62823972    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CA8
chr8:61183683(-) A-I      intronic
chr8:61175805(-) A-I      intronic
chr8:61174558(-) A-I      intronic
chr8:61190192(-) A-I      intronic
chr8:61190187(-) A-I      intronic
chr8:61189610(-) A-I      intronic
chr8:61189596(-) A-I      intronic
chr8:61189579(-) A-I      intronic
chr8:61189556(-) A-I      intronic
chr8:61183684(-) A-I      intronic
chr8:61183115(-) A-I      intronic
chr8:61175665(-) A-I      intronic
chr8:61165669(-) A-I      intronic
chr8:61165659(-) A-I      intronic
chr8:61165672(-) A-I      intronic
chr8:61165682(-) A-I      intronic
chr8:61159138(-) A-I      intronic
chr8:61183735(-) A-I      intronic
chr8:61159136(-) A-I      intronic
chr8:61168564(-) A-I      intronic
chr8:61183748(-) A-I      intronic
chr8:61121877(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CA8
chr8:61121401-61121402(-) m6A CDS//exon       24981863//26404942
chr8:61193698-61193699(-) m6A CDS//exon       27371828//27773536
chr8:61193894-61193895(-) m6A 5'UTR//exon       24981863//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-5p
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
CA8
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-5p
Interactor2: CA8

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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