Basic Information:

  VIRBase ID:  

HHID00004001

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          BNIP3L:  NM_004331     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	BNIP3L
miRBase Accession/Entrez ID	MIMAT0000458	665
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BNIP3a//NIX

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	BNIP3L	chr8:26242518(+) A-I      intronic chr8:26242999(+) A-I      intronic chr8:26261318(+) A-I      intronic chr8:26244001(+) A-I      intronic chr8:26261152(+) A-I      intronic chr8:26261276(+) A-I      intronic chr8:26261291(+) A-I      intronic chr8:26262190(+) A-I      intronic chr8:26262246(+) A-I      intronic chr8:26263372(+) A-I      intronic chr8:26263375(+) A-I      intronic chr8:26263448(+) A-I      intronic chr8:26264072(+) A-I      intronic chr8:26264080(+) A-I      intronic chr8:26264111(+) A-I      intronic chr8:26264112(+) A-I      intronic chr8:26264153(+) A-I      intronic chr8:26264250(+) A-I      intronic chr8:26264319(+) A-I      intronic chr8:26264573(+) A-I      intronic chr8:26264819(+) A-I      intronic chr8:26264841(+) A-I      intronic chr8:26242314(+) A-I      intronic chr8:26243012(+) A-I      intronic chr8:26242444(+) A-I      intronic chr8:26264209(+) A-I      intronic chr8:26264184(+) A-I      intronic chr8:26264949(+) A-I      intronic chr8:26265028(+) A-I      intronic chr8:26264545(+) A-I      intronic chr8:26264217(+) A-I      intronic chr8:26261192(+) A-I      intronic chr8:26244051(+) A-I      intronic chr8:26242851(+) A-I      intronic chr8:26247744(+) A-I      intronic chr8:26242965(+) A-I      intronic chr8:26247692(+) A-I      intronic chr8:26242291(+) A-I      intronic chr8:26261258(+) A-I      intronic chr8:26246439(+) A-I      intronic chr8:26264155(+) A-I      intronic chr8:26265053(+) A-I      intronic chr8:26266210(+) A-I      intronic chr8:26243025(+) A-I      intronic chr8:26263397(+) A-I      intronic chr8:26262179(+) A-I      intronic chr8:26264976(+) A-I      intronic chr8:26242903(+) A-I      intronic chr8:26244084(+) A-I      intronic chr8:26262304(+) A-I      intronic chr8:26264064(+) A-I      intronic chr8:26262213(+) A-I      intronic chr8:26263439(+) A-I      intronic chr8:26264138(+) A-I      intronic chr8:26243996(+) A-I      intronic chr8:26260258(+) A-I      intronic chr8:26242967(+) A-I      intronic chr8:26264282(+) A-I      intronic chr8:26264909(+) A-I      intronic chr8:26264535(+) A-I      intronic chr8:26246288(+) A-I      intronic chr8:26261245(+) A-I      intronic chr8:26263509(+) A-I      intronic chr8:26261153(+) A-I      intronic chr8:26264651(+) A-I      intronic chr8:26242506(+) A-I      intronic chr8:26242912(+) A-I      intronic chr8:26264253(+) A-I      intronic chr8:26262244(+) A-I      intronic chr8:26242972(+) A-I      intronic chr8:26244068(+) A-I      intronic chr8:26242427(+) A-I      intronic chr8:26246305(+) A-I      intronic chr8:26263406(+) A-I      intronic chr8:26263358(+) A-I      intronic chr8:26265124(+) A-I      intronic chr8:26263543(+) A-I      intronic chr8:26244014(+) A-I      intronic chr8:26242849(+) A-I      intronic chr8:26263304(+) A-I      intronic chr8:26262068(+) A-I      intronic chr8:26246231(+) A-I      intronic chr8:26261292(+) A-I      intronic chr8:26263422(+) A-I      intronic chr8:26262141(+) A-I      intronic chr8:26264227(+) A-I      intronic chr8:26242519(+) A-I      intronic chr8:26242893(+) A-I      intronic chr8:26242969(+) A-I      intronic chr8:26246254(+) A-I      intronic chr8:26246470(+) A-I      intronic chr8:26264136(+) A-I      intronic chr8:26242968(+) A-I      intronic chr8:26261330(+) A-I      intronic chr8:26242966(+) A-I      intronic chr8:26263383(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	BNIP3L	chr8:26260185(+) A-I intron -    22327324 chr8:26261292(+) A-I intron -    22327324 chr8:26264909(+) A-I intron -    22327324 chr8:26242307(+) A-G intron -    22484847 chr8:26242427(+) A-G intron -    22484847 chr8:26242517(+) A-G intron -    22484847 chr8:26242519(+) A-G intron -    22484847 chr8:26242849(+) A-G intron -    22484847 chr8:26242851(+) A-G intron -    22484847 chr8:26242881(+) A-G intron -    22484847 chr8:26242893(+) A-G intron -    22484847 chr8:26242903(+) A-G intron -    22484847 chr8:26242912(+) A-G intron -    22484847 chr8:26242965(+) A-G intron -    22484847 chr8:26242966(+) A-G intron -    22484847 chr8:26242967(+) A-G intron -    22484847 chr8:26242968(+) A-G intron -    22484847 chr8:26242969(+) A-G intron -    22484847 chr8:26242972(+) A-G intron -    22484847 chr8:26243025(+) A-G intron -    22484847 chr8:26243995(+) A-G intron -    22484847 chr8:26244068(+) A-G intron -    22484847 chr8:26244084(+) A-G intron -    22484847 chr8:26247744(+) A-G intron -    22484847 chr8:26260185(+) A-G intron -    22484847 chr8:26261245(+) A-G intron -    22484847 chr8:26261292(+) A-G intron -    22484847 chr8:26262068(+) A-G intron -    22484847 chr8:26262141(+) A-G intron -    22484847 chr8:26262213(+) A-G intron -    22484847 chr8:26262233(+) A-G intron -    22484847 chr8:26262244(+) A-G intron -    22484847 chr8:26262304(+) A-G intron -    22484847 chr8:26263349(+) A-G intron -    22484847 chr8:26263358(+) A-G intron -    22484847 chr8:26263438(+) A-G intron -    22484847 chr8:26263439(+) A-G intron -    22484847 chr8:26264064(+) A-G intron -    22484847 chr8:26264074(+) A-G intron -    22484847 chr8:26264081(+) A-G intron -    22484847 chr8:26264217(+) A-G intron -    22484847 chr8:26264227(+) A-G intron -    22484847 chr8:26264535(+) A-G intron -    22484847 chr8:26264663(+) A-G intron -    22484847 chr8:26264909(+) A-G intron -    22484847 chr8:26264976(+) A-G intron -    22484847 chr8:26265028(+) A-G intron -    22484847 chr8:26265053(+) A-G intron -    22484847 chr8:26265124(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	BNIP3L	chr8:26240571-26240572(+) m6A 5'UTR       24981863 chr8:26248866-26248867(+) m6A CDS//intron       24981863 chr8:26248906-26248907(+) m6A CDS//intron       24981863 chr8:26252804-26252805(+) m6A CDS//intron       24981863 chr8:26253155-26253156(+) m6A exon//intron       24981863 chr8:26265573-26265574(+) m6A CDS//exon       24981863 chr8:26265585-26265586(+) m6A CDS//exon       24981863 chr8:26265598-26265599(+) m6A 3'UTR//CDS//exon       24981863 chr8:26267997-26267998(+) m6A 3'UTR//exon//intron       26404942 chr8:26268004-26268005(+) m6A 3'UTR//exon//intron       26404942 chr8:26268086-26268087(+) m6A 3'UTR//intron       26404942 chr8:26268133-26268134(+) m6A 3'UTR//intron       26404942 chr8:26268390-26268391(+) m6A 3'UTR//intron       27773535 chr8:26268438-26268439(+) m6A 3'UTR//intron       27773535 chr8:26268443-26268444(+) m6A 3'UTR//intron       27773535 chr8:26268504-26268505(+) m6A 3'UTR//intron       27773535 chr8:26268569-26268570(+) m6A 3'UTR//intron       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	BNIP3L	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Endoplasmic reticulum Human fibrosarcoma cells (HT1080)     25753659 Exosome Blood     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: BNIP3L

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).