Detail Information

Basic Information:


  VIRBase ID:  

HHID00003989

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:           ATP2B2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-5p ATP2B2
miRBase
Accession/Entrez ID		 MIMAT0000458 491
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - PMCA2//PMCA2a//PMCA2i

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-5p
rs1018706777 chr15:62823984    A/G
rs1369926402 chr15:62823991    G/A
rs1555521311 chr15:62823990    G/C
rs755866868 chr15:62823986    A/G
rs766742872 chr15:62823990    GGTT/G
rs777464613 chr15:62823987    T/G
rs1228899174 chr15:62823974    T/A
rs1281303771 chr15:62823976    T/C
rs1350000299 chr15:62823972    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ATP2B2
chr3:10402912(-) A-I      intronic
chr3:10424182(-) A-I      intronic
chr3:10424175(-) A-I      intronic
chr3:10424169(-) A-I      intronic
chr3:10424168(-) A-I      intronic
chr3:10424163(-) A-I      intronic
chr3:10424159(-) A-I      intronic
chr3:10419484(-) A-I      intronic
chr3:10402929(-) A-I      intronic
chr3:10419433(-) A-I      intronic
chr3:10424155(-) A-I      intronic
chr3:10402975(-) A-I      intronic
chr3:10406165(-) A-I      intronic
chr3:10402948(-) A-I      intronic
chr3:10402952(-) A-I      intronic
chr3:10402993(-) A-I      intronic
chr3:10523411(-) A-I      intronic
chr3:10402953(-) A-I      intronic
chr3:10523280(-) A-I      intronic
chr3:10532155(-) A-I      intronic
chr3:10481577(-) A-I      intronic
chr3:10532123(-) A-I      intronic
chr3:10406160(-) A-I      intronic
chr3:10423969(-) A-I      intronic
chr3:10483161(-) A-I      intronic
chr3:10533048(-) A-I      intronic
chr3:10423992(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ATP2B2
chr3:10367789-10367790(-) m6A 3'UTR       27773535
chr3:10367921-10367922(-) m6A 3'UTR       27773535
chr3:10368061-10368062(-) m6A 3'UTR       27773535
chr3:10368231-10368232(-) m6A 3'UTR       27773535
chr3:10368249-10368250(-) m6A 3'UTR       27773535
chr3:10368365-10368366(-) m6A 3'UTR       27773535//22575960
chr3:10368428-10368429(-) m6A 3'UTR       27773535
chr3:10368490-10368491(-) m6A 3'UTR       24981863//27773535
chr3:10368562-10368563(-) m6A 3'UTR       24981863//27773535//22575960
chr3:10368574-10368575(-) m6A 3'UTR       24981863//27773535//22575960
chr3:10368670-10368671(-) m6A 3'UTR       27773535//22575960
chr3:10368675-10368676(-) m6A 3'UTR       27773535//22575960
chr3:10368720-10368721(-) m6A 3'UTR       27773535//22575960
chr3:10368738-10368739(-) m6A 3'UTR       27773535
chr3:10368768-10368769(-) m6A 3'UTR       27773535
chr3:10368800-10368801(-) m6A 3'UTR       27773535
chr3:10369337-10369338(-) m6A 3'UTR       27773535
chr3:10369354-10369355(-) m6A 3'UTR       27773535
chr3:10369606-10369607(-) m6A 3'UTR       27773535
chr3:10369623-10369624(-) m6A 3'UTR       27773535
chr3:10369689-10369690(-) m6A 3'UTR       27773535
chr3:10369850-10369851(-) m6A 3'UTR       27773535
chr3:10369907-10369908(-) m6A 3'UTR       27773535
chr3:10369916-10369917(-) m6A 3'UTR       27773535
chr3:10369924-10369925(-) m6A 3'UTR       27773535
chr3:10370055-10370056(-) m6A 3'UTR       27773535
chr3:10370072-10370073(-) m6A 3'UTR       27773535
chr3:10370079-10370080(-) m6A 3'UTR       27773535
chr3:10370209-10370210(-) m6A 3'UTR//exon       25456834//24981863//27773535
chr3:10370215-10370216(-) m6A 3'UTR//exon       25456834//24981863//27773535
chr3:10370241-10370242(-) m6A 3'UTR//exon       25456834//24981863//27773535
chr3:10370312-10370313(-) m6A 3'UTR//exon       25456834//24981863//27773535
chr3:10370341-10370342(-) m6A 3'UTR//exon       25456834//24981863//27773535//22575960
chr3:10370361-10370362(-) m6A 3'UTR//exon       25456834//24981863//27773535//22575960
chr3:10370380-10370381(-) m6A 3'UTR//exon       25456834//24981863//27773535//22575960
chr3:10370460-10370461(-) m6A 3'UTR//exon       25456834//24981863//27773535//22575960
chr3:10370490-10370491(-) m6A 3'UTR//exon       27773535//22575960
chr3:10370603-10370604(-) m6A 3'UTR//CDS//exon       27773535
chr3:10370633-10370634(-) m6A 3'UTR//CDS//exon       27773535
chr3:10370745-10370746(-) m6A 3'UTR//CDS//exon       27773535
chr3:10373616-10373617(-) m6A 3'UTR//intron       27773535
chr3:10373702-10373703(-) m6A 3'UTR//exon//intron       27773535
chr3:10373709-10373710(-) m6A 3'UTR//exon//intron       27773535
chr3:10373845-10373846(-) m6A exon//intron       27773535
chr3:10373869-10373870(-) m6A exon//intron       27773535
chr3:10373966-10373967(-) m6A exon//intron       27773535
chr3:10380015-10380016(-) m6A CDS       27773535
chr3:10381977-10381978(-) m6A CDS       27773535
chr3:10382326-10382327(-) m6A CDS       27773535
chr3:10384491-10384492(-) m6A CDS       27773535
chr3:10387761-10387762(-) m6A CDS       27773535
chr3:10391815-10391816(-) m6A CDS       27773535
chr3:10392139-10392140(-) m6A CDS       27773535
chr3:10413551-10413552(-) m6A CDS       27773535
chr3:10413650-10413651(-) m6A CDS       27773535
chr3:10413655-10413656(-) m6A CDS       27773535
chr3:10413686-10413687(-) m6A CDS       27773535
chr3:10420089-10420090(-) m6A CDS       27773535
chr3:10429661-10429662(-) m6A exon//intron       27773535
chr3:10430023-10430024(-) m6A CDS//exon       27773535
chr3:10430031-10430032(-) m6A CDS//exon       27773535
chr3:10430083-10430084(-) m6A CDS//exon       27773535
chr3:10442653-10442654(-) m6A CDS//exon       27773535
chr3:10491043-10491044(-) m6A CDS//exon       27773535
chr3:10491072-10491073(-) m6A CDS//exon       27773535
chr3:10491082-10491083(-) m6A CDS//exon       27773535
chr3:10491189-10491190(-) m6A CDS//exon       27773535//22575960
chr3:10491228-10491229(-) m6A 5'UTR//exon       27773535//22575960
chr3:10491238-10491239(-) m6A 5'UTR//exon       27773535//22575960
chr3:10491308-10491309(-) m6A 5'UTR//exon       22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-5p
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
ATP2B2
Exosome Blood     -
Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-5p
Interactor2: ATP2B2

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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