Detail Information

Basic Information:


  VIRBase ID:  

HHID00003980

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:           AQP4:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-5p AQP4
miRBase
Accession/Entrez ID		 MIMAT0000458 361
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - MIWC//WCH4

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-5p
rs1018706777 chr15:62823984    A/G
rs1369926402 chr15:62823991    G/A
rs1555521311 chr15:62823990    G/C
rs755866868 chr15:62823986    A/G
rs766742872 chr15:62823990    GGTT/G
rs777464613 chr15:62823987    T/G
rs1228899174 chr15:62823974    T/A
rs1281303771 chr15:62823976    T/C
rs1350000299 chr15:62823972    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR AQP4
chr18:24438075(-) A-I      intronic
chr18:24438124(-) A-I      intronic
chr18:24438005(-) A-I      intronic
chr18:24437415(-) A-I      intronic
chr18:24437423(-) A-I      intronic
chr18:24438051(-) A-I      intronic
chr18:24438201(-) A-I      intronic
chr18:24438092(-) A-I      intronic
chr18:24438114(-) A-I      intronic
chr18:24437990(-) A-I      intronic
chr18:24438127(-) A-I      intronic
chr18:24437562(-) A-I      intronic
chr18:24438136(-) A-I      intronic
chr18:24438062(-) A-I      intronic
chr18:24438231(-) A-I      intronic
chr18:24438141(-) A-I      intronic
chr18:24437334(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase AQP4
chr18:24436135-24436136(-) m6A 3'UTR       25456834//27773535
chr18:24436145-24436146(-) m6A 3'UTR       25456834//27773535
chr18:24436150-24436151(-) m6A 3'UTR       25456834//27773535
chr18:24436205-24436206(-) m6A CDS       25456834//27773535//22575960//22608085
chr18:24436261-24436262(-) m6A CDS//exon       25456834//27773535//22575960//22608085
chr18:24436301-24436302(-) m6A CDS//exon       25456834//27773535//22575960//22608085
chr18:24436329-24436330(-) m6A CDS//exon       25456834//27773535//22575960//22608085
chr18:24442358-24442359(-) m6A CDS//exon       25456834//22575960
chr18:24442408-24442409(-) m6A CDS       22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-5p
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
AQP4
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-5p
Interactor2: AQP4

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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