Detail Information

Basic Information:


  VIRBase ID:  

HHID00003975

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:           ALCAM:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-5p ALCAM
miRBase
Accession/Entrez ID		 MIMAT0000458 214
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CD166//MEMD

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-5p
rs1018706777 chr15:62823984    A/G
rs1369926402 chr15:62823991    G/A
rs1555521311 chr15:62823990    G/C
rs755866868 chr15:62823986    A/G
rs766742872 chr15:62823990    GGTT/G
rs777464613 chr15:62823987    T/G
rs1228899174 chr15:62823974    T/A
rs1281303771 chr15:62823976    T/C
rs1350000299 chr15:62823972    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ALCAM
chr3:105104729(+) A-I      intronic
chr3:105093136(+) A-I      intronic
chr3:105213643(+) A-I      intronic
chr3:105213634(+) A-I      intronic
chr3:105213571(+) A-I      intronic
chr3:105174747(+) A-I      intronic
chr3:105174694(+) A-I      intronic
chr3:105174672(+) A-I      intronic
chr3:105124042(+) A-I      intronic
chr3:105173642(+) A-I      intronic
chr3:105161702(+) A-I      intronic
chr3:105161545(+) A-I      intronic
chr3:105161504(+) A-I      intronic
chr3:105124041(+) A-I      intronic
chr3:105123960(+) A-I      intronic
chr3:105093213(+) A-I      intronic
chr3:105281719(+) A-I      intronic
chr3:105213645(+) A-I      intronic
chr3:105093584(+) A-I      intronic
chr3:105213705(+) A-I      intronic
chr3:105283823(+) A-I      intronic
chr3:105174030(+) A-I      intronic
chr3:105283792(+) A-I      intronic
chr3:105161348(+) A-I      intronic
chr3:105161872(+) A-I      intronic
chr3:105161944(+) A-I      intronic
chr3:105161417(+) A-I      intronic
chr3:105161703(+) A-I      intronic
chr3:105161697(+) A-I      intronic
chr3:105123860(+) A-I      intronic
chr3:105155276(+) A-I      intronic
chr3:105166302(+) A-I      intronic
chr3:105173655(+) A-I      intronic
chr3:105201069(+) A-I      intronic
chr3:105174785(+) A-I      intronic
chr3:105161753(+) A-I      intronic
chr3:105283635(+) A-I      intronic
chr3:105093142(+) A-I      intronic
chr3:105283690(+) A-I      intronic
chr3:105173658(+) A-I      intronic
chr3:105283628(+) A-I      intronic
chr3:105093571(+) A-I      intronic
chr3:105161786(+) A-I      intronic
chr3:105283730(+) A-I      intronic
chr3:105161370(+) A-I      intronic
chr3:105283753(+) A-I      intronic
chr3:105161371(+) A-I      intronic
chr3:105283759(+) A-I      intronic
chr3:105213573(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ALCAM
chr3:105289183(+) A-I intron -    21960545
chr3:105289183(+) A-G intron -    22484847
chr3:105093138(+) A-G intron -    22484847
chr3:105093142(+) A-G intron -    22484847
chr3:105093464(+) G-A intron -    22484847
chr3:105093571(+) A-G intron -    22484847
chr3:105093584(+) A-G intron -    22484847
chr3:105121806(+) C-T intron -    22484847
chr3:105123860(+) A-G intron -    22484847
chr3:105161348(+) A-G intron -    22484847
chr3:105161370(+) A-G intron -    22484847
chr3:105161371(+) A-G intron -    22484847
chr3:105161697(+) A-G intron -    22484847
chr3:105161703(+) A-G intron -    22484847
chr3:105161872(+) A-G intron -    22484847
chr3:105161944(+) A-G intron -    22484847
chr3:105166302(+) A-G intron -    22484847
chr3:105173655(+) A-G intron -    22484847
chr3:105173658(+) A-G intron -    22484847
chr3:105174031(+) A-G intron -    22484847
chr3:105201069(+) A-G intron -    22484847
chr3:105213573(+) A-G intron -    22484847
chr3:105213661(+) A-G intron -    22484847
chr3:105213705(+) A-G intron -    22484847
chr3:105213713(+) T-C intron -    22484847
chr3:105283655(+) C-T intron -    22484847
chr3:105283753(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ALCAM
chr3:105085766-105085767(+) m6A 5'UTR//exon       24209618//24981863//22608085
chr3:105085812-105085813(+) m6A 5'UTR//exon       24209618//24981863//22608085
chr3:105085940-105085941(+) m6A 5'UTR//exon       24209618//25456834//24981863//26404942//22608085
chr3:105085981-105085982(+) m6A 5'UTR//exon       24209618//25456834//24981863//26404942//22575960//22608085
chr3:105086093-105086094(+) m6A 5'UTR//exon       24209618//25456834//24981863//26404942//22575960//22608085
chr3:105086160-105086161(+) m6A 5'UTR//exon       24209618//25456834//24981863//26404942//22575960//22608085
chr3:105086217-105086218(+) m6A 5'UTR//exon       24209618//25456834//24981863//22608085
chr3:105253536-105253537(+) m6A CDS//exon       26404942
chr3:105253583-105253584(+) m6A CDS//exon       26404942
chr3:105253636-105253637(+) m6A CDS//exon       26404942
chr3:105253652-105253653(+) m6A CDS//exon       26404942
chr3:105253666-105253667(+) m6A CDS//exon       26404942
chr3:105260478-105260479(+) m6A CDS//exon//intron       26404942
chr3:105260546-105260547(+) m6A CDS//exon//intron       26404942
chr3:105260567-105260568(+) m6A CDS//exon//intron       26404942
chr3:105266237-105266238(+) m6A CDS//exon       26404942
chr3:105266262-105266263(+) m6A CDS//exon       26404942
chr3:105266276-105266277(+) m6A CDS//exon       26404942
chr3:105266286-105266287(+) m6A CDS//exon       26404942
chr3:105266334-105266335(+) m6A CDS//exon       26404942
chr3:105266362-105266363(+) m6A CDS//exon       26404942
chr3:105290707-105290708(+) m6A CDS//exon       24981863//27773535//22608085
chr3:105290715-105290716(+) m6A CDS//exon       24981863//27773535//22608085
chr3:105290721-105290722(+) m6A CDS//exon       24981863//27773535//22608085
chr3:105290742-105290743(+) m6A CDS//exon       24981863//27773535//22608085
chr3:105290760-105290761(+) m6A CDS//exon       24981863//27773535//22608085
chr3:105290771-105290772(+) m6A CDS//exon       24981863//27773535//22608085
chr3:105290790-105290791(+) m6A 3'UTR//exon       24981863//27773535//22608085
chr3:105293337-105293338(+) m6A 3'UTR//exon       24981863//27773535//22608085
chr3:105293371-105293372(+) m6A 3'UTR//exon       24981863//26404942//27773535//22608085
chr3:105293377-105293378(+) m6A 3'UTR//exon       24981863//26404942//27773535//22608085
chr3:105293383-105293384(+) m6A 3'UTR//exon       24981863//26404942//22608085
chr3:105293468-105293469(+) m6A 3'UTR//exon       24981863//26404942//22608085
chr3:105293489-105293490(+) m6A 3'UTR//exon       24981863//26404942//22608085
chr3:105293498-105293499(+) m6A 3'UTR//exon       24981863//26404942//22608085
chr3:105293808-105293809(+) m6A 3'UTR//exon       26404942
chr3:105293832-105293833(+) m6A 3'UTR//exon       26404942
chr3:105293873-105293874(+) m6A 3'UTR//exon       24981863//26404942
chr3:105293881-105293882(+) m6A 3'UTR//exon       24981863//26404942
chr3:105293919-105293920(+) m6A 3'UTR//exon       24981863//26404942
chr3:105293950-105293951(+) m6A 3'UTR//exon       24981863//26404942
chr3:105293976-105293977(+) m6A 3'UTR//exon       24981863//26404942
chr3:105294004-105294005(+) m6A 3'UTR//exon       24981863//26404942
chr3:105294011-105294012(+) m6A 3'UTR//exon       26404942
chr3:105294040-105294041(+) m6A 3'UTR//exon       26404942
chr3:105294077-105294078(+) m6A 3'UTR//exon       26404942
chr3:105294096-105294097(+) m6A 3'UTR//exon       26404942
chr3:105294602-105294603(+) m6A 3'UTR//exon       26404942//27773535
chr3:105294660-105294661(+) m6A 3'UTR//exon       26404942//27773535
chr3:105294682-105294683(+) m6A 3'UTR//exon       26404942//27773535
chr3:105294708-105294709(+) m6A 3'UTR//exon       26404942//27773535
chr3:105294727-105294728(+) m6A 3'UTR//exon       26404942//27773535
chr3:105295214-105295215(+) m6A 3'UTR       27773535
chr3:105295390-105295391(+) m6A 3'UTR       24981863//26404942//27773535//22608085
chr3:105295402-105295403(+) m6A 3'UTR       24981863//26404942//27773535//22608085
chr3:105295416-105295417(+) m6A 3'UTR       24981863//26404942//27773535//22608085
chr3:105295425-105295426(+) m6A 3'UTR       24981863//26404942//27773535//22608085
chr3:105295439-105295440(+) m6A 3'UTR       24981863//26404942//27773535//22608085
chr3:105295473-105295474(+) m6A 3'UTR       24981863//26404942//27773535//22608085
chr3:105295628-105295629(+) m6A 3'UTR       24981863//27773535//22608085
chr3:105295727-105295728(+) m6A 3'UTR       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-5p
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
ALCAM
Cytosol HCC cell line (HepG2)     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-5p
Interactor2: ALCAM

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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