Basic Information:

  VIRBase ID:  

HHID00003964

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:  MIMAT0000458          ACTN4:  NM_004924     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-5p	ACTN4
miRBase Accession/Entrez ID	MIMAT0000458	81
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ACTININ-4//FSGS//FSGS1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-5p	rs1018706777 chr15:62823984    A/G rs1369926402 chr15:62823991    G/A rs1555521311 chr15:62823990    G/C rs755866868 chr15:62823986    A/G rs766742872 chr15:62823990    GGTT/G rs777464613 chr15:62823987    T/G rs1228899174 chr15:62823974    T/A rs1281303771 chr15:62823976    T/C rs1350000299 chr15:62823972    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ACTN4	chr19:39142472(+) A-I      intronic chr19:39142471(+) A-I      intronic chr19:39149898(+) A-I      intronic chr19:39143579(+) A-I      intronic chr19:39149842(+) A-I      intronic chr19:39149837(+) A-I      intronic chr19:39170388(+) A-I      intronic chr19:39194853(+) A-I      intronic chr19:39205938(+) A-I      intronic chr19:39194132(+) A-I      intronic chr19:39142476(+) A-I      intronic chr19:39207346(+) A-I      intronic chr19:39142431(+) A-I      intronic chr19:39149830(+) A-I      intronic chr19:39142453(+) A-I      intronic chr19:39194789(+) A-I      intronic chr19:39161484(+) A-I      intronic chr19:39161483(+) A-I      intronic chr19:39149846(+) A-I      intronic chr19:39142489(+) A-I      intronic chr19:39142456(+) A-I      intronic chr19:39142475(+) A-I      intronic chr19:39142498(+) A-I      intronic chr19:39194791(+) A-I      intronic chr19:39145042(+) A-I      intronic chr19:39145006(+) A-I      intronic chr19:39145001(+) A-I      intronic chr19:39145162(+) A-I      intronic chr19:39145157(+) A-I      intronic chr19:39159836(+) A-I      intronic chr19:39159810(+) A-I      intronic chr19:39159753(+) A-I      intronic chr19:39159752(+) A-I      intronic chr19:39159726(+) A-I      intronic chr19:39159676(+) A-I      intronic chr19:39159252(+) A-I      intronic chr19:39159140(+) A-I      intronic chr19:39152324(+) A-I      intronic chr19:39149764(+) A-I      intronic chr19:39147733(+) A-I      intronic chr19:39146996(+) A-I      intronic chr19:39146982(+) A-I      intronic chr19:39146972(+) A-I      intronic chr19:39146900(+) A-I      intronic chr19:39146892(+) A-I      intronic chr19:39146882(+) A-I      intronic chr19:39145219(+) A-I      intronic chr19:39145189(+) A-I      intronic chr19:39145121(+) A-I      intronic chr19:39146935(+) A-I      intronic chr19:39159900(+) A-I      intronic chr19:39163313(+) A-I      intronic chr19:39163314(+) A-I      intronic chr19:39163343(+) A-I      intronic chr19:39163352(+) A-I      intronic chr19:39163682(+) A-I      intronic chr19:39163712(+) A-I      intronic chr19:39163748(+) A-I      intronic chr19:39163851(+) A-I      intronic chr19:39170930(+) A-I      intronic chr19:39206797(+) A-I      intronic chr19:39206668(+) A-I      intronic chr19:39206087(+) A-I      intronic chr19:39206078(+) A-I      intronic chr19:39206069(+) A-I      intronic chr19:39206016(+) A-I      intronic chr19:39206010(+) A-I      intronic chr19:39206006(+) A-I      intronic chr19:39205990(+) A-I      intronic chr19:39205985(+) A-I      intronic chr19:39205981(+) A-I      intronic chr19:39205979(+) A-I      intronic chr19:39205875(+) A-I      intronic chr19:39205873(+) A-I      intronic chr19:39194860(+) A-I      intronic chr19:39194728(+) A-I      intronic chr19:39194679(+) A-I      intronic chr19:39193935(+) A-I      intronic chr19:39193934(+) A-I      intronic chr19:39182464(+) A-I      intronic chr19:39182449(+) A-I      intronic chr19:39182423(+) A-I      intronic chr19:39173098(+) A-I      intronic chr19:39173086(+) A-I      intronic chr19:39173062(+) A-I      intronic chr19:39173059(+) A-I      intronic chr19:39171707(+) A-I      intronic chr19:39171659(+) A-I      intronic chr19:39171510(+) A-I      intronic chr19:39171504(+) A-I      intronic chr19:39170943(+) A-I      intronic chr19:39170948(+) A-I      intronic chr19:39145087(+) A-I      intronic chr19:39145081(+) A-I      intronic chr19:39206642(+) A-I      intronic chr19:39182333(+) A-I      intronic chr19:39159073(+) A-I      intronic chr19:39206683(+) A-I      intronic chr19:39207290(+) A-I      intronic chr19:39142648(+) A-I      intronic chr19:39207240(+) A-I      intronic chr19:39194820(+) A-I      intronic chr19:39170413(+) A-I      intronic chr19:39181953(+) A-I      intronic chr19:39163763(+) A-I      intronic chr19:39194058(+) A-I      intronic chr19:39171055(+) A-I      intronic chr19:39179064(+) A-I      intronic chr19:39193979(+) A-I      intronic chr19:39180310(+) A-I      intronic chr19:39159081(+) A-I      intronic chr19:39207210(+) A-I      intronic chr19:39194045(+) A-I      intronic chr19:39178799(+) A-I      intronic chr19:39163772(+) A-I      intronic chr19:39150621(+) A-I      intronic chr19:39172529(+) A-I      intronic chr19:39149881(+) A-I      intronic chr19:39194804(+) A-I      intronic chr19:39209187(+) A-I      intronic chr19:39150702(+) A-I      intronic chr19:39206681(+) A-I      intronic chr19:39180207(+) A-I      intronic chr19:39205881(+) A-I      intronic chr19:39206635(+) A-I      intronic chr19:39180250(+) A-I      intronic chr19:39182392(+) A-I      intronic chr19:39159727(+) A-I      intronic chr19:39159139(+) A-I      intronic chr19:39163722(+) A-I      intronic chr19:39206581(+) A-I      intronic chr19:39194691(+) A-I      intronic chr19:39163660(+) A-I      intronic chr19:39194859(+) A-I      intronic chr19:39182514(+) A-I      intronic chr19:39207419(+) A-I      intronic chr19:39159247(+) A-I      intronic chr19:39206645(+) A-I      intronic chr19:39179132(+) A-I      intronic chr19:39159205(+) A-I      intronic chr19:39194786(+) A-I      intronic chr19:39159346(+) A-I      intronic chr19:39209104(+) A-I      intronic chr19:39144973(+) A-I      intronic chr19:39179287(+) A-I      intronic chr19:39145122(+) A-I      intronic chr19:39175775(+) A-I      intronic chr19:39206641(+) A-I      intronic chr19:39182385(+) A-I      intronic chr19:39206691(+) A-I      intronic chr19:39153606(+) A-I      intronic chr19:39145063(+) A-I      intronic chr19:39163683(+) A-I      intronic chr19:39159232(+) A-I      intronic chr19:39180488(+) A-I      intronic chr19:39206667(+) A-I      intronic chr19:39163142(+) A-I      intronic chr19:39206112(+) A-I      intronic chr19:39153571(+) A-I      intronic chr19:39159056(+) A-I      intronic chr19:39180453(+) A-I      intronic chr19:39180163(+) A-I      intronic chr19:39159169(+) A-I      intronic chr19:39179369(+) A-I      intronic chr19:39194733(+) A-I      intronic chr19:39171511(+) A-I      intronic chr19:39159179(+) A-I      intronic chr19:39143676(+) A-I      intronic chr19:39144946(+) A-I      intronic chr19:39205937(+) A-I      intronic chr19:39194769(+) A-I      intronic chr19:39181800(+) A-I      intronic chr19:39161513(+) A-I      intronic chr19:39206598(+) A-I      intronic chr19:39206548(+) A-I      intronic chr19:39206603(+) A-I      intronic chr19:39149971(+) A-I      intronic chr19:39143691(+) A-I      intronic chr19:39193978(+) A-I      intronic chr19:39180491(+) A-I      intronic chr19:39163766(+) A-I      intronic chr19:39171533(+) A-I      intronic chr19:39194840(+) A-I      intronic chr19:39159678(+) A-I      intronic chr19:39159254(+) A-I      intronic chr19:39159739(+) A-I      intronic chr19:39145055(+) A-I      intronic chr19:39207386(+) A-I      intronic chr19:39171768(+) A-I      intronic chr19:39178866(+) A-I      intronic chr19:39144992(+) A-I      intronic chr19:39149865(+) A-I      intronic chr19:39193943(+) A-I      intronic chr19:39179570(+) A-I      intronic chr19:39171042(+) A-I      intronic chr19:39153650(+) A-I      intronic chr19:39180231(+) A-I      intronic chr19:39159165(+) A-I      intronic chr19:39164694(+) A-I      intronic chr19:39194906(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ACTN4	chr19:39170285(+) A-I intron -    21960545 chr19:39143676(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ACTN4	chr19:39138354-39138355(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//26404942//27371828//22575960//22608085 chr19:39138392-39138393(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27371828//22575960//22608085 chr19:39138407-39138408(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27371828//22575960//22608085 chr19:39138500-39138501(+) m6A CDS//exon       24284625//24209618//24981863//26404942//22575960//22608085 chr19:39138506-39138507(+) m6A CDS//exon       24284625//24209618//24981863//26404942//22575960//22608085 chr19:39138518-39138519(+) m6A CDS//exon       24284625//24209618//24981863//26404942//22575960//22608085 chr19:39138842-39138843(+) m6A exon//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr19:39138874-39138875(+) m6A exon//intron       24284625//24209618//26404942//22575960//22608085 chr19:39191284-39191285(+) Cm CDS//exon//intron       - chr19:39191294-39191295(+) m6A CDS//exon//intron       24284625//24209618//26404942//27773535//22575960 chr19:39191306-39191307(+) m6A CDS//exon//intron       24284625//24209618//26404942//27773535//22575960 chr19:39191701-39191702(+) m6A CDS//exon//intron       24284625//24209618//26404942//22575960 chr19:39191713-39191714(+) m6A CDS//exon//intron       24284625//24209618//26404942//22575960 chr19:39195617-39195618(+) m6A CDS//exon//intron       26404942//22575960 chr19:39195645-39195646(+) m6A CDS//exon//intron       26404942//22575960 chr19:39196685-39196686(+) m6A CDS//exon//intron       26404942//22575960 chr19:39196727-39196728(+) m6A CDS//exon//intron       22575960 chr19:39196758-39196759(+) m6A CDS//exon//intron       22575960 chr19:39198801-39198802(+) m6A CDS//exon//intron       26404942//27773535//22575960 chr19:39200056-39200057(+) m6A CDS//exon//intron       26404942//27773535//22575960 chr19:39200905-39200906(+) m6A CDS//exon//intron       26404942//22575960 chr19:39201485-39201486(+) m6A exon//intron       26404942//22575960 chr19:39205114-39205115(+) m6A CDS//exon//intron       26404942//22575960 chr19:39205178-39205179(+) m6A CDS//exon//intron       24284625//26404942//22575960 chr19:39207765-39207766(+) m6A CDS//exon//intron       24284625//26404942//22575960 chr19:39207782-39207783(+) m6A CDS//exon//intron       24284625//26404942//22575960 chr19:39207813-39207814(+) m6A CDS//exon//intron       24284625//26404942//22575960 chr19:39207896-39207897(+) m6A CDS//exon//intron       24284625//26404942//22575960 chr19:39208596-39208597(+) Cm CDS//exon//intron       - chr19:39208707-39208708(+) m6A CDS//exon//intron       24284625//26404942//22575960 chr19:39212204-39212205(+) m6A CDS//exon//intron       24284625//26404942//22575960 chr19:39212228-39212229(+) m6A CDS//exon//intron       24284625//26404942//22575960 chr19:39212288-39212289(+) m6A CDS//exon//intron       24284625//26404942//22575960 chr19:39212345-39212346(+) m6A exon//intron       24284625//22575960 chr19:39212383-39212384(+) m6A exon//intron       24284625 chr19:39214579-39214580(+) m6A CDS//intron       26404942//22575960 chr19:39214673-39214674(+) m6A CDS//intron       26404942//22575960 chr19:39214682-39214683(+) m6A CDS//intron       26404942//27773535//22575960 chr19:39215095-39215096(+) m6A CDS//intron       24284625//26404942//22575960 chr19:39215193-39215194(+) m6A CDS//intron       24284625//26404942//27773535//22575960 chr19:39216396-39216397(+) m6A CDS//intron       24284625//26404942//27773535//22575960 chr19:39216406-39216407(+) m6A CDS//intron       24284625//26404942//27773535//22575960 chr19:39216448-39216449(+) m6A CDS//intron       24284625//26404942//27773535//22575960 chr19:39216466-39216467(+) m6A CDS//intron       24284625//26404942//27773535//22575960 chr19:39217660-39217661(+) m6A CDS//intron       24284625//26404942//22575960 chr19:39218468-39218469(+) Y intron       25192136 chr19:39218811-39218812(+) m6A exon//intron       24284625//22575960 chr19:39218961-39218962(+) m6A CDS//exon//intron       - chr19:39218974-39218975(+) m6A CDS//exon//intron       - chr19:39219731-39219732(+) m6A CDS//exon//intron       24284625//22575960 chr19:39219744-39219745(+) m6A CDS//exon//intron       24284625//22575960 chr19:39219789-39219790(+) m6A CDS//exon//intron       24284625//26404942//22575960 chr19:39220082-39220083(+) m6A 3'UTR//exon//intron       24284625//24981863//26404942//22575960 chr19:39220482-39220483(+) m6A 3'UTR//intron       24284625//22575960 chr19:39220540-39220541(+) m6A 3'UTR//intron       24284625//24981863//22575960 chr19:39220573-39220574(+) m6A 3'UTR//intron       24284625//24981863//22575960 chr19:39220645-39220646(+) m6A 3'UTR//CDS       24284625//24981863//27773535//22575960 chr19:39220660-39220661(+) m6A 3'UTR       24284625//24981863//27773535//22575960 chr19:39220727-39220728(+) m6A 3'UTR       24981863//27773535//22608085 chr19:39220751-39220752(+) m6A 3'UTR       24981863//27773535//22608085 chr19:39220758-39220759(+) m6A 3'UTR       24981863//27773535//22608085 chr19:39220767-39220768(+) m6A 3'UTR       24981863//27773535//22608085 chr19:39220792-39220793(+) m6A 3'UTR       24981863//27773535//22608085 chr19:39220800-39220801(+) m6A 3'UTR       24981863//27773535//22608085 chr19:39220824-39220825(+) m6A 3'UTR       24981863//27773535//22608085 chr19:39220930-39220931(+) m6A 3'UTR       27773535 chr19:39221002-39221003(+) m6A 3'UTR       27773535//22575960 chr19:39221121-39221122(+) m6A 3'UTR       27773535//27371828 chr19:39221135-39221136(+) m6A 3'UTR       27773535//27371828 chr19:39221148-39221149(+) m6A 3'UTR       27773535//27371828 chr19:39221269-39221270(+) m6A 3'UTR       27773535 chr19:39221375-39221376(+) m6A 3'UTR       27773535 chr19:39221386-39221387(+) m6A 3'UTR       27773535 chr19:39221776-39221777(+) m6A 3'UTR       27773535 chr19:39221782-39221783(+) m6A 3'UTR       27773535 chr19:39221903-39221904(+) m6A 3'UTR       27773535 chr19:39221946-39221947(+) m6A 3'UTR       27773535 chr19:39222053-39222054(+) m6A 3'UTR       24981863 chr19:39222059-39222060(+) m6A 3'UTR       24981863 chr19:39222088-39222089(+) m6A 3'UTR       24981863 chr19:39222102-39222103(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
	ACTN4	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-5p
Interactor2: ACTN4

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).