Detail Information

Basic Information:


  VIRBase ID:  

HHID00003962

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:           NAT1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-5p NAT1
miRBase
Accession/Entrez ID		 MIMAT0000458 9
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - AAC1//MNAT//NAT-1//NATI

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-5p
rs1018706777 chr15:62823984    A/G
rs1369926402 chr15:62823991    G/A
rs1555521311 chr15:62823990    G/C
rs755866868 chr15:62823986    A/G
rs766742872 chr15:62823990    GGTT/G
rs777464613 chr15:62823987    T/G
rs1228899174 chr15:62823974    T/A
rs1281303771 chr15:62823976    T/C
rs1350000299 chr15:62823972    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR NAT1
chr8:18052182(+) A-I      intronic
chr8:18047473(+) A-I      intronic
chr8:18047482(+) A-I      intronic
chr8:18050607(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase NAT1
chr8:18067436-18067437(+) m6A exon       24981863
chr8:18067629-18067630(+) m6A 5'UTR//intron       24981863
chr8:18068722-18068723(+) m6A 5'UTR//exon//intron       24981863
chr8:18068728-18068729(+) m6A 5'UTR//exon//intron       24981863
chr8:18068756-18068757(+) m6A 5'UTR//exon//intron       24981863
chr8:18068766-18068767(+) m6A 5'UTR//exon//intron       24981863
chr8:18069944-18069945(+) m6A 5'UTR//exon//intron       24981863
chr8:18069949-18069950(+) m6A 5'UTR//exon//intron       24981863
chr8:18069957-18069958(+) m6A 5'UTR//exon//intron       24981863
chr8:18076962-18076963(+) m6A 5'UTR//CDS//exon       24981863
chr8:18079560-18079561(+) m6A CDS//exon       24981863//22608085
chr8:18079605-18079606(+) m6A CDS//exon       24981863//22608085
chr8:18079614-18079615(+) m6A CDS//exon       25456834//24981863//22608085
chr8:18079622-18079623(+) m6A CDS//exon       25456834//24981863//22608085
chr8:18079671-18079672(+) m6A CDS//exon       25456834//24981863//22608085
chr8:18079701-18079702(+) m6A CDS//exon       24284625//25456834//24981863//27773535//22608085
chr8:18079811-18079812(+) m6A CDS//exon       24284625//25456834//24981863//22608085
chr8:18079908-18079909(+) m6A CDS//exon       24284625//24981863//22608085
chr8:18080040-18080041(+) m6A CDS//exon       24284625//25456834//24981863//22608085
chr8:18080056-18080057(+) m6A CDS//exon       24284625//25456834//24981863//22608085
chr8:18080103-18080104(+) m6A CDS//exon       24284625//24981863//22608085
chr8:18080147-18080148(+) m6A CDS//exon       24981863//22608085
chr8:18080186-18080187(+) m6A CDS//exon       24981863//22608085
chr8:18080234-18080235(+) m6A CDS//exon       24981863//22608085
chr8:18080298-18080299(+) m6A CDS       24981863//22608085
chr8:18080324-18080325(+) m6A CDS       24981863//22608085
chr8:18080401-18080402(+) m6A CDS       24981863
chr8:18080442-18080443(+) m6A 3'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-5p
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
NAT1
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-5p
Interactor2: NAT1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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