Detail Information

Basic Information:


  VIRBase ID:  

HHID00003961

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:           FAM182B:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-5p FAM182B
miRBase
Accession/Entrez ID		 MIMAT0000458 728882
Organism Homo sapiens Homo sapiens
Category miRNA lncRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-5p
rs1018706777 chr15:62823984    A/G
rs1369926402 chr15:62823991    G/A
rs1555521311 chr15:62823990    G/C
rs755866868 chr15:62823986    A/G
rs766742872 chr15:62823990    GGTT/G
rs777464613 chr15:62823987    T/G
rs1228899174 chr15:62823974    T/A
rs1281303771 chr15:62823976    T/C
rs1350000299 chr15:62823972    G/A
Resource Symbol SNP ID SNP Position Ref/Alt PMID
LincSNP 3.0 FAM182B
rs2185914 chr20:25864357 A/C         17554300
rs6138659 chr20:25775423 A/C         20339536
rs2424737 chr20:25778020 A/G         20339536
rs6115330 chr20:25853354 A/G         20339536
rs6115350 chr20:25866328 A/G         20339536
rs6050936 chr20:25853437 A/G         22451204
rs6138686 chr20:25848249 C/T         23722424

RNA Editing:


Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED FAM182B
chr20:25752311(-) A-I exon 3'UTR    15342557
chr20:25753184(-) A-I exon 3'UTR    15342557
chr20:25753340(-) A-I exon 3'UTR    15342557
chr20:25753351(-) A-I exon 3'UTR    15342557
chr20:25753385(-) A-I exon 3'UTR    15342557
chr20:25753396(-) A-I exon 3'UTR    15342557
chr20:25753436(-) A-I exon 3'UTR    15342557
chr20:25753450(-) A-I exon 3'UTR    15342557
chr20:25753477(-) A-I exon 3'UTR    15342557
chr20:25753505(-) A-I exon 3'UTR    15342557
chr20:25753534(-) A-I exon 3'UTR    15342557
chr20:25753542(-) A-I exon 3'UTR    15342557
chr20:25753549(-) A-I exon 3'UTR    15342557
chr20:25753575(-) A-I exon 3'UTR    15342557
chr20:25754018(-) A-I exon 3'UTR    15342557
chr20:25754019(-) A-I exon 3'UTR    15342557

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-5p
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
FAM182B
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-190a-5p
Curcumin 969516 Drug interaction    RC00003255
Vincristine 5978 Drug interaction    RC00003250
D-Glucose 5793 Drug interaction    RC00003249
Naringin 442428 Drug interaction    RC00003254
5-Fluorouracil 3385 Drug interaction    RC00003248
Enoxacin 3229 Drug interaction    RC00003247
Doxorubicin 31703 Drug interaction    RC00003251
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003246
Verapamil 2520 Drug interaction    RC00003245
Flavylium 145858 Drug interaction    RC00003253
Proanthocyanidin 108065 Drug interaction    RC00003252
Resource Symbol Drug Name PubChem ID
RNAactDrug FAM182B
6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide       9956222
Benzamide, N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]-       9952773
1,2-Ethanediamine, N-(1,8-dimethylimidazo(1,2-a)quinoxalin-4-yl)-, monohydrochloride       9926054
Tivozanib       9911830
Zibotentan       9910224
5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide       9903786
2-(((5-(4-(4-(3-Fluorobenzyloxy)-3-chlorophenylamino)quinazolin-6-yl)furan-2-yl)methyl)(2-(methylsulfonyl)ethyl)amino)acetonitrile       9873849
Osi-930       9868037
2-(4-(Benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine       9858940
9H-Purine, 6-(ethylthio)-9-beta-D-ribofuranosyl-(8CI)(9CI)       95846
6-Benzylthioinosine       95263
Sulfonaphtholazoresorcinol       85517
Acetic acid, [(aminoiminomethyl)thio]-       81899
(E)-1-(2-Hydroxyphenyl)-3-((1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)prop-2-en-1-one       78243717
Phenyl(tribromomethyl)mercury       76801
4,4'-Dithiodimorpholine       7648
Etymemazine hydrochloride       71822
N-(3-Methylphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine       704473
(S)-N-Hydroxy-4-(3-methyl-2-phenylbutanamido)benzamide       6918848
Panobinostat       6918837
Daporinad       6914657
N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamide       6852167
Brigatinib       68165256
17-Hydroxyjolkinolide B       6712607
AICA ribonucleotide       65110
1-Phenyl-3-[(3-phenylimidazolidin-1-yl)methyl]imidazolidine       6482345
Ispinesib mesylate       6450816
Axitinib       6450551
Nilotinib       644241
Cytarabine       6253
Irinotecan       60838
Topotecan       60700
Mitomycin       5746
Methyl N-[6-[4-[[2-fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1,3-benzothiazol-2-yl]carbamate;hydrochloride       57401572
Methyl N-[6-[3-[[2-fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1H-benzimidazol-2-yl]carbamate;hydrochloride       57399798
l-685,458       5479543
Austocystin D       5470400
Lfm-a13       54676905
2-Methylthiazolidine-2,4-dicarbonylic acid-di-sodium salt       54612624
Iridogermanal       5458843
Cristatic acid       5458761
Senecionine N-oxide       5380876
N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide       53340664
Palbociclib       5330286
Vorinostat       5311
Imatinib       5291
Alsterpaullone       5005498
Tubastatin A       49850262
Probucol       4912
2-[(4s)-6-(4-Chlorophenyl)-8-Methoxy-1-Methyl-4h-[1,2,4]triazolo[4,3-A][1,4]benzodiazepin-4-Yl]-N-Ethylacetamide       46943432
3-(4-(4-(2-(3-((Dimethylamino)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl)phenyl)-1,1-dimethylurea       46885626
N-(6,6-Dimethyl-5-(1-methylpiperidine-4-carbonyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-3-methylbutanamide       46191454
N-(2,2,2-Trifluoroethyl)-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}benzenesulfonamide       447912
1-(6,7-Dimethoxyquinazolin-4-yl)-3-(pyridin-2-yl)-1H-1,2,4-triazol-5-amine       44551660
Tretinoin       444795
2-Chlorophenylhydrazine hydrochloride       443287
Pyrodelphinine       431677
Foretinib       42642645
5-Fluoro-2-(3-Ethoxy-4-hydroxyphenyl)benzothiazole       404994
Methyl 5-[2-(2,5-dimethoxyphenyl)ethynyl]-2-methoxybenzoate       403337
23-O-Acetylshengmanol xyloside       399180
Ethyl-diphenyl-(2-phenylethynyl)phosphanium;iodide       386463
Etoposide       36462
1,2,4,5-Tetrazine, 3,6-bis(1-azetidinyl)-       362170
5-Fluorouracil       3385
Methyl ciliarate       338441
Ehretinine       336435
2-Methyl-2-[4-(Naphthalen-1-Yl)phenoxy]propanoic Acid       327338
Clomifene citrate       3033832
AT 116, benzylamine salt       282523
[5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol       25262965
2-(4-Methyl-1,4-diazepan-1-yl)-N-((5-methylpyrazin-2-yl)methyl)-5-oxo-5H-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxamide       25257557
Ruxolitinib       25126798
Cabozantinib       25102847
Navitoclax       24978538
Tert-Butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate       24951314
Quizartinib       24889392
Ponatinib       24826799
Vismodegib       24776445
4-(6,6-Dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide       24772860
Vincaleukoblastine       241903
Menisperine iodide       24189461
Olaparib       23725625
Tenulin       227830
4-((4-Hydroxyphenyl)diazenyl)phenylarsonic acid       224279
Nutlin-3       216345
Lenalidomide       216326
Sorafenib       216239
Kinetin riboside       20345
5-Benzyloxybenzylbarbituric acid       192294
3,4-Dihydro-3,3-dimethyl-2H-naphtho[2,3-b]pyran-5,10-dione       178515
Adiantifoline       167937
4-Methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide       16747388
Gsk-690693       16725726
Fedratinib       16722836
1-(Tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea       1401
Astrazon Orange R       135747272
(Z)-3-((3-((Dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide       135659062
Osi-027       135398516
Dovitinib       135398510
Akt inhibitor VIII       135398501
Abiraterone       132971
Methotrexate       126941
Lestaurtinib       126565
Veliparib       11960529
BAY 61-3606 dihydrochloride       11784504
N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-YL)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide       11754511
1-Methyl-5-[[2-[5-(trifluoromethyl)-1h-imidazol-2-yl]-4-pyridinyl]oxy]-n-[4-(trifluoromethyl)phenyl]-1h-benzimidazol-2-amine       11656518
Crizotinib       11626560
Idelalisib       11625818
5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine       11617559
Benzamide, 4-((1R)-1-aminoethyl)-N-1H-pyrrolo(2,3-b)pyridin-4-yl-, hydrochloride (1:1)       11507964
5-(2-Phenylpyrazolo[1,5-A]pyridin-3-YL)-1H-pyrazolo[3,4-C]pyridazin-3-amine       11493598
Linifanib       11485656
Bafetinib       11387605
N-(6-Fluoro-1H-indazol-5-yl)-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamide       11373846
8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one       11327430
Pararosaniline hydrochloride       11292
Amuvatinib       11282283
3-(4-Amino-3-(3-chloro-4-fluorophenyl)thieno[3,2-c]pyridin-7-yl)benzenesulfonamide       11281930
(S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide       11152667
7-Ethyl-10-hydroxycamptothecin       104842
VX-702       10341154
Selumetinib       10127622
Masitinib       10074640
1,1'-(benzo[d][1,3]dioxol-5-ylmethylene)dipiperazine       -
5,6-ethylenediquino[3,2-b       -
(8-8a),(8'-8'a)-tetradehydroisocalycanthine 3'a(r),3'a(r)       -
Basic Fuchsin       -
Cisplatin       -
crotoxin cd       -
Genentech Cpd 10       -
KIN001-236       -
KIN001-244       -
KIN001-260       -
KIN001-270       -
MPS-1-IN-1       -
NPK76-II-72-1       -
Nutlin-3a (-)       -
pararosaniline pamoate       -
protein toxin a 23 - mw approx. 6700       -
protein toxin c 10 - mw approx. 6700       -
QL-XI-92       -
QL-XII-47       -
THZ-2-102-1       -
TL-1-85       -
TL-2-105       -
VNLG/124       -
XMD13-2       -
XMD14-99       -
XMD15-27       -
(z)3,4,5-trimethoxystilbene       -
;(Z)-5-Chloro-2-(1-methyl-5-nitroimidazole-2-ylmethylene...       -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-5p
Interactor2: FAM182B

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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