Detail Information

Basic Information:


  VIRBase ID:  

HHID00003960

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-5p:           ST7-OT4:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-5p ST7-OT4
miRBase
Accession/Entrez ID		 MIMAT0000458 338069
Organism Homo sapiens Homo sapiens
Category miRNA lncRNA
Alias - NCRNA00042//ST7OT4

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-5p
rs1018706777 chr15:62823984    A/G
rs1369926402 chr15:62823991    G/A
rs1555521311 chr15:62823990    G/C
rs755866868 chr15:62823986    A/G
rs766742872 chr15:62823990    GGTT/G
rs777464613 chr15:62823987    T/G
rs1228899174 chr15:62823974    T/A
rs1281303771 chr15:62823976    T/C
rs1350000299 chr15:62823972    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ST7-OT4
chr7:116608496(+) A-I      3'UTR
chr7:116608535(+) A-I      3'UTR

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ST7-OT4
chr7:116594084-116594085(+) m6A exon       25456834//27773536
chr7:116594110-116594111(+) m6A exon       25456834//27773536
chr7:116594134-116594135(+) m6A exon       25456834//27773536
chr7:116660445-116660446(+) m6A intron       22575960//22608085
chr7:116660474-116660475(+) m6A intron       22575960//22608085
chr7:116660508-116660509(+) m6A intron       24981863//22575960//22608085
chr7:116660519-116660520(+) m6A intron       24981863//22575960//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-5p
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
ST7-OT4
Chromatin K562 cells     -
Cytosol K562 cells     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-190a-5p
Curcumin 969516 Drug interaction    RC00003255
Vincristine 5978 Drug interaction    RC00003250
D-Glucose 5793 Drug interaction    RC00003249
Naringin 442428 Drug interaction    RC00003254
5-Fluorouracil 3385 Drug interaction    RC00003248
Enoxacin 3229 Drug interaction    RC00003247
Doxorubicin 31703 Drug interaction    RC00003251
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003246
Verapamil 2520 Drug interaction    RC00003245
Flavylium 145858 Drug interaction    RC00003253
Proanthocyanidin 108065 Drug interaction    RC00003252
Resource Symbol Drug Name PubChem ID
RNAactDrug ST7-OT4
Piperidine, 2-methyl-6-undecyl-       99090
Panobinostat       6918837
Rifamycin       6324616
Irinotecan       60838
Topotecan       60700
Idoxuridine       5905
l-685,458       5479543
9-alpha-Hydroxyparthenolide       5477074
Selendale       54601159
[(1R,2R,4R,8R,11Z,13R)-4,6,6,11-Tetramethyl-16-methylidene-10,15-dioxo-5,7,14-trioxatricyclo[11.3.0.04,8]hexadec-11-en-2-yl] (Z)-2-methylbut-2-enoate       5351315
Palbociclib       5330286
Oxanosine       477547
Silver sulfadiazine       441244
Bis(4-methylpiperazin-1-yl)methanethione       388906
2-Bromo-8-hydroxy-6-methylnaphthoquinone       378439
Paclitaxel       36314
Shikoccin       327536
Rustaiyan A       324967
Carnosol O-quinone       323275
Tenulin       227830
(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl propionate       227681
Propiophenone, 3-phenyl-3-piperidino-       219163
7-Hydroxychlorpromazine       16414
2,4,5,6-Tetrachloropyrimidine       15690
Dovitinib       135398510
1-Methyl-5-[[2-[5-(trifluoromethyl)-1h-imidazol-2-yl]-4-pyridinyl]oxy]-n-[4-(trifluoromethyl)phenyl]-1h-benzimidazol-2-amine       11656518
Pha-665752       10461815
Methyl 2-[(2R,4R,6R,10S,12R,13R)-10,13-diacetyloxy-4,15-dimethyl-8-oxo-3,7,17-trioxatetracyclo[12.2.1.16,9.02,4]octadeca-1(16),9(18),14-trien-12-yl]prop-2-enoate       101607568
;1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1...       -
;5-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)-6-(4-fluoroph...       -
;(E)-3-(2-(2-hydroxybenzylidene)hydrazinyl)-1,2,4-triazi...       -
geldanamycin, n,n'-dimethyl       -
indole-2,3-dione, 3-[(pentafluorophenyl)hydrazone]       -
;N-cyclohexyl-4-((1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4...       -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-5p
Interactor2: ST7-OT4

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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