Basic Information:

  VIRBase ID:  

HHID00003899

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-23b-3p:  MIMAT0000418          UBE2D1:  NM_003338     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-23b-3p	UBE2D1
miRBase Accession/Entrez ID	MIMAT0000418	7321
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	E2(17)KB1//SFT//UBC4/5//UBCH5//UBCH5A

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-23b-3p	rs1165985173 chr9:95085265    A/G rs1316630116 chr9:95085276    A/G rs1356837387 chr9:95085278    G/T rs567029494 chr9:95085287    C/A rs567029494 chr9:95085287    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	UBE2D1	chr10:60105144(+) A-I      intronic chr10:60105124(+) A-I      intronic chr10:60124982(+) A-I      intronic chr10:60105131(+) A-I      intronic chr10:60105002(+) A-I      intronic chr10:60105174(+) A-I      intronic chr10:60105104(+) A-I      intronic chr10:60104976(+) A-I      intronic chr10:60098978(+) A-I      intronic chr10:60098995(+) A-I      intronic chr10:60105137(+) A-I      intronic chr10:60120543(+) A-I      intronic chr10:60104649(+) A-I      intronic chr10:60120509(+) A-I      intronic chr10:60126530(+) A-I      intronic chr10:60124992(+) A-I      intronic chr10:60126581(+) A-I      intronic chr10:60120604(+) A-I      intronic chr10:60105114(+) A-I      intronic chr10:60104975(+) A-I      intronic chr10:60120460(+) A-I      intronic chr10:60120689(+) A-I      intronic chr10:60104834(+) A-I      intronic chr10:60120430(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	UBE2D1	chr10:60094736-60094737(+) m6A 5'UTR       25456834//24981863//27371828//27773536 chr10:60094808-60094809(+) m6A 5'UTR       24284625//25456834//24981863//27371828//27773536 chr10:60094847-60094848(+) m6A 5'UTR       25456834//24981863//27371828//27773536 chr10:60127766-60127767(+) m6A CDS//exon       27773535 chr10:60128488-60128489(+) m6A CDS//exon       24981863//22608085 chr10:60128504-60128505(+) m6A CDS//exon       24981863//22608085 chr10:60128534-60128535(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr10:60128628-60128629(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr10:60128671-60128672(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr10:60128676-60128677(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr10:60128701-60128702(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr10:60128743-60128744(+) m6A 3'UTR//exon       24981863//22608085 chr10:60128772-60128773(+) m6A 3'UTR//exon       24981863//22608085 chr10:60128840-60128841(+) m6A 3'UTR//exon       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-23b-3p	Apoptotic body Human umbilical vein endothelial cells     19996457 Cytoplasm Cell line (HeLa)     21695135 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Renal cancer cells     21670082 Exosome Ovarian follicular fluid     22116803 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Endothelial cells|Epithelial cells|Seminal fluid|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Myotube     27396686 Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Colon adenocarcinoma cells     20864815
	UBE2D1	Exosome Blood     - Nucleoplasm K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-23b-3p	Arjunolic acid 73641 Drug resistant Phosphotrienin 6913994 Drug resistant Adenosine, 2-bromo-2'-deoxy- 55914 Drug resistant Plumericin 5281545 Drug resistant Jolkinolide B 161954 Drug resistant (1S,3R,7Z,9R,12S,13R,15S)-13-Butan-2-yl-13-hydroxy-3,7,12-trimethyl-10,14,16-trioxatetracyclo[7.5.1.13,6.012,15]hexadeca-5,7-diene-4,11-dione 11972510 Drug resistant 6-[4-(1-Cyclohexenyl)-1,3-butadiyn-1-yl]-2(2H)-pyranone 10263039 Drug resistant 2-(1-(2-fluorophenylsulfonyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide - Drug resistant 2-methylellpticinium - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-23b-3p	Curcumin 969516 Drug interaction    RC00002484 Formaldehyde 712 Drug interaction    RC00002465 Medroxyprogesterone acetate 6279 Drug interaction    RC00002473 Alocrest 60780 Drug interaction    RC00002478 Vincristine 5978 Drug interaction    RC00002472 D-Glucose 5793 Drug interaction    RC00002471 Estradiol 5757 Drug interaction    RC00002470 Temozolomide 5394 Drug interaction    RC00002469 Eloxatine 5310940 Drug interaction    RC00002486 Morphine 5288826 Drug interaction    RC00002485 Decitabine 451668 Drug interaction    RC00002483 Trichostatin A 444732 Drug interaction    RC00002482 Cyclopamine 442972 Drug interaction    RC00002481 Etoposide 36462 Drug interaction    RC00002477 Paclitaxel 36314 Drug interaction    RC00002476 5-Fluorouracil 3385 Drug interaction    RC00002468 Doxorubicin 31703 Drug interaction    RC00002475 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002467 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00002487 Bicalutamide 2375 Drug interaction    RC00002466 Arsenic trioxide 14888 Drug interaction    RC00002474 Ginsenoside Rh2 119307 Drug interaction    RC00002480 Bevacizumab - Drug interaction    RC00002488 platinum-based doublet chemotherapy - Drug interaction    RC00002489 5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00002490 Hydroxamic acid HDACi LAQ824 - Drug interaction    RC00002491

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-23b-3p	Cisplatin 5702198       25996293 Cisplatin 5702198       29162158 Paclitaxel 36314       26323677 5-Fluorouracil 3385       25996293 5-Fluorouracil 3385       29162158 Doxorubicin 31703       25698578 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124 Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       25996293

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-23b-3p
Interactor2: UBE2D1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).