Detail Information

Basic Information:


  VIRBase ID:  

HHID00003358

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-29b-3p:           NHLRC2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-29b-3p NHLRC2
miRBase
Accession/Entrez ID		 MIMAT0000100 374354
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - FINCA

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-29b-3p
rs868994683 chr7:130877473    G/A
rs1390817128 chr1:207802451    A/G
rs773555186 chr1:207802453    A/C
rs773555186 chr1:207802453    A/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR NHLRC2
chr10:115675649(+) A-I      3'UTR
chr10:115675599(+) A-I      3'UTR
chr10:115675642(+) A-I      3'UTR
chr10:115627361(+) A-I      intronic
chr10:115675657(+) A-I      3'UTR
chr10:115675663(+) A-I      3'UTR
chr10:115675665(+) A-I      3'UTR
chr10:115624907(+) A-I      intronic
chr10:115624765(+) A-I      intronic
chr10:115624225(+) A-I      intronic
chr10:115624336(+) A-I      intronic
chr10:115624248(+) A-I      intronic
chr10:115624915(+) A-I      intronic
chr10:115624301(+) A-I      intronic
chr10:115624270(+) A-I      intronic
chr10:115624838(+) A-I      intronic
chr10:115624850(+) A-I      intronic
chr10:115648807(+) A-I      intronic
chr10:115624809(+) A-I      intronic
chr10:115624303(+) A-I      intronic
chr10:115624397(+) A-I      intronic
chr10:115624388(+) A-I      intronic
chr10:115624821(+) A-I      intronic
chr10:115647731(+) A-I      intronic
chr10:115621736(+) A-I      intronic
chr10:115624281(+) A-I      intronic
chr10:115624295(+) A-I      intronic
chr10:115624363(+) A-I      intronic
chr10:115621735(+) A-I      intronic
chr10:115624848(+) A-I      intronic
chr10:115624732(+) A-I      intronic
chr10:115624201(+) A-I      intronic
chr10:115624335(+) A-I      intronic
chr10:115622644(+) A-I      intronic
chr10:115624271(+) A-I      intronic
chr10:115666584(+) A-I      intronic
chr10:115647807(+) A-I      intronic
chr10:115666560(+) A-I      intronic
chr10:115675443(+) A-I      3'UTR
chr10:115628720(+) A-I      intronic
chr10:115631057(+) A-I      intronic
chr10:115628722(+) A-I      intronic
chr10:115628689(+) A-I      intronic
chr10:115675666(+) A-I      3'UTR
chr10:115670145(+) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED NHLRC2
chr10:115628689(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase NHLRC2
chr10:115614440-115614441(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr10:115614455-115614456(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr10:115614470-115614471(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr10:115614549-115614550(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr10:115614557-115614558(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr10:115614586-115614587(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//22608085
chr10:115614629-115614630(+) m6A 5'UTR//exon       24209618//25456834//22608085
chr10:115614685-115614686(+) m6A CDS//exon       24209618
chr10:115614734-115614735(+) m6A CDS//exon       -
chr10:115614782-115614783(+) m6A CDS//exon       24284625
chr10:115618301-115618302(+) m6A CDS//exon       24284625
chr10:115618311-115618312(+) m6A CDS//exon       24284625
chr10:115618468-115618469(+) m6A exon//intron       24981863
chr10:115636415-115636416(+) m6A CDS       24284625//24981863//22575960//22608085
chr10:115636454-115636455(+) m6A CDS       24284625//24981863//22575960//22608085
chr10:115636465-115636466(+) m6A CDS       24284625//24981863//22575960//22608085
chr10:115636493-115636494(+) m6A CDS       24284625//24981863//22575960//22608085
chr10:115636546-115636547(+) m6A CDS       24284625//24209618//24981863//22608085
chr10:115636583-115636584(+) m6A CDS       24284625//24981863//22608085
chr10:115636642-115636643(+) m6A CDS       24284625//24981863//22608085
chr10:115636672-115636673(+) m6A CDS       24284625//24981863//22608085
chr10:115636679-115636680(+) m6A CDS       24284625//24981863//22608085
chr10:115636712-115636713(+) m6A CDS       24981863//22608085
chr10:115644132-115644133(+) m6A CDS       24981863
chr10:115664631-115664632(+) m6A CDS       24284625//24981863
chr10:115664638-115664639(+) m6A CDS       24284625//24981863
chr10:115664649-115664650(+) m6A CDS       24284625//24981863//22608085
chr10:115664707-115664708(+) m6A CDS       24284625//24209618//24981863//22608085
chr10:115664721-115664722(+) m6A CDS       24284625//24209618//24981863//22608085
chr10:115664732-115664733(+) m6A CDS       24284625//24209618//24981863//22608085
chr10:115668060-115668061(+) m6A CDS       24284625//24209618//24981863//22608085
chr10:115668086-115668087(+) m6A CDS       24284625//24209618//24981863//22608085
chr10:115668188-115668189(+) m6A CDS       24284625
chr10:115668373-115668374(+) m6A 3'UTR       24981863
chr10:115668951-115668952(+) m6A 3'UTR       24981863//22608085
chr10:115668972-115668973(+) m6A 3'UTR       24981863//22608085
chr10:115668989-115668990(+) m6A 3'UTR       24981863//22608085
chr10:115669076-115669077(+) m6A 3'UTR       24981863//22608085
chr10:115669084-115669085(+) m6A 3'UTR       24981863//22608085
chr10:115674950-115674951(+) m6A 3'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-29b-3p
Cytoplasm HeLa cells     28185889
Cytoplasm Hepatic carcinoma cells (Huh-7)     29253196
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Urine     26576778
Exosome HCC tissues     30542726
Exosome Saliva     19627513
Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Epithelial cells|Seminal fluid|Tongue tissue     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Hela cells|NIH-3T3 cells     17204650
Nucleus HeLa cells     28185889
Nucleus Hepatic carcinoma cells (Huh-7)     29253196
Nucleus HeLa cells     30006350
Nucleus Nasopharyngeal carcinoma cells     20498841
NHLRC2
Chromatin K562 cells     -
Cytosol K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-29b-3p
Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug resistant
Phenyl gallate 333279 Drug resistant
N-[(4R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris(3-aminopropoxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentyl]octan-1-amine 24205348 Drug sensitive
8-Hydroxyquinoline 1923 Drug resistant
(R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug sensitive
Acid Alizarine Red B 135565636 Drug resistant
2-Acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 Drug resistant
1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant
4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug resistant
naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)- - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-29b-3p
Formaldehyde 712 Drug interaction    RC00001120
Oxaliplatine 6857599 Drug interaction    RC00001140
Gemcitabine 60750 Drug interaction    RC00001131
Progesterone 5994 Drug interaction    RC00001126
D-Glucose 5793 Drug interaction    RC00001125
Eloxatine 5310940 Drug interaction    RC00001139
Imatinib 5291 Drug interaction    RC00001124
Decitabine 451668 Drug interaction    RC00001137
Docosahexaenoic acid 445580 Drug interaction    RC00001136
Trichostatin A 444732 Drug interaction    RC00001135
Cyclopamine 442972 Drug interaction    RC00001134
Bortezomib 387447 Drug interaction    RC00001133
Etoposide 36462 Drug interaction    RC00001130
Paclitaxel 36314 Drug interaction    RC00001129
5-Fluorouracil 3385 Drug interaction    RC00001123
Enoxacin 3229 Drug interaction    RC00001122
Doxorubicin 31703 Drug interaction    RC00001128
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001121
Tamoxifen 2733526 Drug interaction    RC00001138
Ixazomib 25183872 Drug interaction    RC00001144
Navitoclax 24978538 Drug interaction    RC00001143
Ampligen & InterferonalphaA 16197265 Drug interaction    RC00001142
Leucovorin 135403648 Drug interaction    RC00001145
Ginsenoside Rh2 119307 Drug interaction    RC00001132
Carfilzomib 11556711 Drug interaction    RC00001141
Androstanolone 10635 Drug interaction    RC00001127
Chemotherapy - Drug interaction    RC00001146
5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00001147
Glucocorticoid - Drug interaction    RC00001148
Testosterone + 1,25-Dihydroxyvitamin D3 - Drug interaction    RC00001149
Trastuzumab - Drug interaction    RC00001150
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-29b-3p
Bortezomib 387447       30728351

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-29b-3p
Interactor2: NHLRC2

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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