Basic Information:

  VIRBase ID:  

HHID00003303

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-29b-3p:  MIMAT0000100          GRPEL2:  NM_152407     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-29b-3p	GRPEL2
miRBase Accession/Entrez ID	MIMAT0000100	134266
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	Mt-GrpE#2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-29b-3p	rs868994683 chr7:130877473    G/A rs1390817128 chr1:207802451    A/G rs773555186 chr1:207802453    A/C rs773555186 chr1:207802453    A/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GRPEL2	chr5:148728733(+) A-I      intronic chr5:148726430(+) A-I      intronic chr5:148728719(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GRPEL2	chr5:148725100-148725101(+) m6A 5'UTR       24284625//24981863 chr5:148725214-148725215(+) m6A exon//intron       24284625//24981863 chr5:148725347-148725348(+) m6A exon//intron       - chr5:148727871-148727872(+) m6A CDS//exon       - chr5:148727884-148727885(+) m6A CDS//exon       - chr5:148727899-148727900(+) m6A CDS//exon       - chr5:148727960-148727961(+) m6A CDS//exon       27773535 chr5:148729250-148729251(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22608085 chr5:148729264-148729265(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22608085 chr5:148729412-148729413(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr5:148730501-148730502(+) m6A CDS//exon       24284625//25456834//24981863//22608085 chr5:148730533-148730534(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:148730570-148730571(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr5:148730661-148730662(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr5:148730703-148730704(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr5:148730763-148730764(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:148730778-148730779(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:148730838-148730839(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:148730859-148730860(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:148730909-148730910(+) m6A 3'UTR//exon       24284625//25456834//24981863//22575960//22608085 chr5:148733905-148733906(+) m6A 3'UTR//exon       27773535 chr5:148734025-148734026(+) m6A 3'UTR//exon       24981863//27773535 chr5:148734052-148734053(+) m6A 3'UTR//exon       24981863//27773535 chr5:148734081-148734082(+) m6A 3'UTR//exon       27773535 chr5:148734111-148734112(+) m6A 3'UTR//exon       27773535 chr5:148734125-148734126(+) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-29b-3p	Cytoplasm HeLa cells     28185889 Cytoplasm Hepatic carcinoma cells (Huh-7)     29253196 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Urine     26576778 Exosome HCC tissues     30542726 Exosome Saliva     19627513 Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Epithelial cells|Seminal fluid|Tongue tissue     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Hela cells|NIH-3T3 cells     17204650 Nucleus HeLa cells     28185889 Nucleus Hepatic carcinoma cells (Huh-7)     29253196 Nucleus HeLa cells     30006350 Nucleus Nasopharyngeal carcinoma cells     20498841
	GRPEL2	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-29b-3p	Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug resistant Phenyl gallate 333279 Drug resistant N-[(4R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris(3-aminopropoxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentyl]octan-1-amine 24205348 Drug sensitive 8-Hydroxyquinoline 1923 Drug resistant (R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug sensitive Acid Alizarine Red B 135565636 Drug resistant 2-Acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 Drug resistant 1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant 4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug resistant naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)- - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-29b-3p	Formaldehyde 712 Drug interaction    RC00001120 Oxaliplatine 6857599 Drug interaction    RC00001140 Gemcitabine 60750 Drug interaction    RC00001131 Progesterone 5994 Drug interaction    RC00001126 D-Glucose 5793 Drug interaction    RC00001125 Eloxatine 5310940 Drug interaction    RC00001139 Imatinib 5291 Drug interaction    RC00001124 Decitabine 451668 Drug interaction    RC00001137 Docosahexaenoic acid 445580 Drug interaction    RC00001136 Trichostatin A 444732 Drug interaction    RC00001135 Cyclopamine 442972 Drug interaction    RC00001134 Bortezomib 387447 Drug interaction    RC00001133 Etoposide 36462 Drug interaction    RC00001130 Paclitaxel 36314 Drug interaction    RC00001129 5-Fluorouracil 3385 Drug interaction    RC00001123 Enoxacin 3229 Drug interaction    RC00001122 Doxorubicin 31703 Drug interaction    RC00001128 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001121 Tamoxifen 2733526 Drug interaction    RC00001138 Ixazomib 25183872 Drug interaction    RC00001144 Navitoclax 24978538 Drug interaction    RC00001143 Ampligen & InterferonalphaA 16197265 Drug interaction    RC00001142 Leucovorin 135403648 Drug interaction    RC00001145 Ginsenoside Rh2 119307 Drug interaction    RC00001132 Carfilzomib 11556711 Drug interaction    RC00001141 Androstanolone 10635 Drug interaction    RC00001127 Chemotherapy - Drug interaction    RC00001146 5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00001147 Glucocorticoid - Drug interaction    RC00001148 Testosterone + 1,25-Dihydroxyvitamin D3 - Drug interaction    RC00001149 Trastuzumab - Drug interaction    RC00001150

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-29b-3p	Bortezomib 387447       30728351

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-29b-3p
Interactor2: GRPEL2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).