Basic Information:

  VIRBase ID:  

HHID00003302

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-29b-3p:  MIMAT0000100          JMY:  NM_152405     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-29b-3p	JMY
miRBase Accession/Entrez ID	MIMAT0000100	133746
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	WHAMM2//WHDC1L3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-29b-3p	rs868994683 chr7:130877473    G/A rs1390817128 chr1:207802451    A/G rs773555186 chr1:207802453    A/C rs773555186 chr1:207802453    A/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	JMY	chr5:78533315(+) A-I      NonSyn:Glu->Gly chr5:78535397(+) A-I      intronic chr5:78612564(+) A-I      intronic chr5:78609879(+) A-I      intronic chr5:78541523(+) A-I      intronic chr5:78539981(+) A-I      intronic chr5:78536400(+) A-I      intronic chr5:78536203(+) A-I      intronic chr5:78536099(+) A-I      intronic chr5:78536098(+) A-I      intronic chr5:78536089(+) A-I      intronic chr5:78536068(+) A-I      intronic chr5:78535975(+) A-I      intronic chr5:78535889(+) A-I      intronic chr5:78535558(+) A-I      intronic chr5:78609762(+) A-I      intronic chr5:78609144(+) A-I      intronic chr5:78574497(+) A-I      intronic chr5:78575015(+) A-I      intronic chr5:78575018(+) A-I      intronic chr5:78575052(+) A-I      intronic chr5:78575770(+) A-I      intronic chr5:78577751(+) A-I      intronic chr5:78609004(+) A-I      intronic chr5:78588168(+) A-I      intronic chr5:78588169(+) A-I      intronic chr5:78535535(+) A-I      intronic chr5:78535442(+) A-I      intronic chr5:78616021(+) A-I      intronic chr5:78616394(+) A-I      intronic chr5:78616343(+) A-I      intronic chr5:78616077(+) A-I      intronic chr5:78616004(+) A-I      intronic chr5:78615962(+) A-I      intronic chr5:78535381(+) A-I      intronic chr5:78615947(+) A-I      intronic chr5:78614081(+) A-I      intronic chr5:78588346(+) A-I      intronic chr5:78607044(+) A-I      intronic chr5:78535542(+) A-I      intronic chr5:78535554(+) A-I      intronic chr5:78535380(+) A-I      intronic chr5:78541528(+) A-I      intronic chr5:78542495(+) A-I      intronic chr5:78542503(+) A-I      intronic chr5:78542557(+) A-I      intronic chr5:78557286(+) A-I      intronic chr5:78559462(+) A-I      intronic chr5:78561009(+) A-I      intronic chr5:78563819(+) A-I      intronic chr5:78563830(+) A-I      intronic chr5:78564428(+) A-I      intronic chr5:78567676(+) A-I      intronic chr5:78567815(+) A-I      intronic chr5:78567855(+) A-I      intronic chr5:78569483(+) A-I      intronic chr5:78569543(+) A-I      intronic chr5:78569548(+) A-I      intronic chr5:78569575(+) A-I      intronic chr5:78570292(+) A-I      intronic chr5:78570429(+) A-I      intronic chr5:78574484(+) A-I      intronic chr5:78574493(+) A-I      intronic chr5:78535375(+) A-I      intronic chr5:78535588(+) A-I      intronic chr5:78535593(+) A-I      intronic chr5:78613864(+) A-I      intronic chr5:78612636(+) A-I      intronic chr5:78612608(+) A-I      intronic chr5:78575784(+) A-I      intronic chr5:78612582(+) A-I      intronic chr5:78575793(+) A-I      intronic chr5:78609052(+) A-I      intronic chr5:78616018(+) A-I      intronic chr5:78572003(+) A-I      intronic chr5:78585002(+) A-I      intronic chr5:78607837(+) A-I      intronic chr5:78553227(+) A-I      intronic chr5:78578001(+) A-I      intronic chr5:78615586(+) A-I      intronic chr5:78542451(+) A-I      intronic chr5:78535507(+) A-I      intronic chr5:78607908(+) A-I      intronic chr5:78575767(+) A-I      intronic chr5:78616274(+) A-I      intronic chr5:78578955(+) A-I      intronic chr5:78588353(+) A-I      intronic chr5:78615999(+) A-I      intronic chr5:78535487(+) A-I      intronic chr5:78607693(+) A-I      intronic chr5:78607665(+) A-I      intronic chr5:78535968(+) A-I      intronic chr5:78612552(+) A-I      intronic chr5:78609095(+) A-I      intronic chr5:78574902(+) A-I      intronic chr5:78612467(+) A-I      intronic chr5:78609157(+) A-I      intronic chr5:78609145(+) A-I      intronic chr5:78607806(+) A-I      intronic chr5:78552674(+) A-I      intronic chr5:78575779(+) A-I      intronic chr5:78609199(+) A-I      intronic chr5:78607740(+) A-I      intronic chr5:78612473(+) A-I      intronic chr5:78536105(+) A-I      intronic chr5:78574319(+) A-I      intronic chr5:78536049(+) A-I      intronic chr5:78542626(+) A-I      intronic chr5:78616113(+) A-I      intronic chr5:78613964(+) A-I      intronic chr5:78536039(+) A-I      intronic chr5:78578915(+) A-I      intronic chr5:78609222(+) A-I      intronic chr5:78569834(+) A-I      intronic chr5:78577909(+) A-I      intronic chr5:78553035(+) A-I      intronic chr5:78557290(+) A-I      intronic chr5:78607061(+) A-I      intronic chr5:78609049(+) A-I      intronic chr5:78575736(+) A-I      intronic chr5:78584938(+) A-I      intronic chr5:78585003(+) A-I      intronic chr5:78542525(+) A-I      intronic chr5:78535523(+) A-I      intronic chr5:78575814(+) A-I      intronic chr5:78616318(+) A-I      intronic chr5:78609001(+) A-I      intronic chr5:78574728(+) A-I      intronic chr5:78616083(+) A-I      intronic chr5:78612618(+) A-I      intronic chr5:78553168(+) A-I      intronic chr5:78599066(+) A-I      intronic chr5:78553298(+) A-I      intronic chr5:78570491(+) A-I      intronic chr5:78573418(+) A-I      intronic chr5:78582303(+) A-I      intronic chr5:78553689(+) A-I      intronic chr5:78609162(+) A-I      intronic chr5:78612609(+) A-I      intronic chr5:78616054(+) A-I      intronic chr5:78607769(+) A-I      intronic chr5:78616003(+) A-I      intronic chr5:78613911(+) A-I      intronic chr5:78575078(+) A-I      intronic chr5:78613905(+) A-I      intronic chr5:78575796(+) A-I      intronic chr5:78606743(+) A-I      intronic chr5:78579072(+) A-I      intronic chr5:78584848(+) A-I      intronic chr5:78544629(+) A-I      intronic chr5:78616299(+) A-I      intronic chr5:78612500(+) A-I      intronic chr5:78609009(+) A-I      intronic chr5:78613904(+) A-I      intronic chr5:78535513(+) A-I      intronic chr5:78563912(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	JMY	chr5:78609162(+) A-I intron -    22327324 chr5:78557243(+) A-I intron -    21960545 chr5:78569502(+) A-I intron -    21960545 chr5:78535452(+) A-G intron -    22484847 chr5:78535487(+) A-G intron -    22484847 chr5:78535513(+) A-G intron -    22484847 chr5:78535968(+) A-G intron -    22484847 chr5:78536039(+) A-G intron -    22484847 chr5:78536048(+) A-G intron -    22484847 chr5:78536049(+) A-G intron -    22484847 chr5:78536105(+) A-G intron -    22484847 chr5:78542451(+) A-G intron -    22484847 chr5:78542525(+) A-G intron -    22484847 chr5:78542554(+) A-G intron -    22484847 chr5:78542584(+) A-G intron -    22484847 chr5:78542626(+) A-G intron -    22484847 chr5:78549169(+) G-A intron -    22484847 chr5:78552674(+) A-G intron -    22484847 chr5:78552741(+) G-C intron -    22484847 chr5:78553689(+) A-G intron -    22484847 chr5:78557290(+) A-G intron -    22484847 chr5:78561726(+) C-T intron -    22484847 chr5:78569834(+) A-G intron -    22484847 chr5:78572613(+) A-G intron -    22484847 chr5:78574902(+) A-G intron -    22484847 chr5:78579072(+) A-G intron -    22484847 chr5:78579074(+) A-G intron -    22484847 chr5:78584938(+) A-G intron -    22484847 chr5:78607740(+) A-G intron -    22484847 chr5:78607837(+) A-G intron -    22484847 chr5:78609145(+) A-G intron -    22484847 chr5:78609157(+) A-G intron -    22484847 chr5:78609162(+) A-G intron -    22484847 chr5:78609214(+) T-C intron -    22484847 chr5:78609708(+) A-G intron -    22484847 chr5:78612473(+) A-G intron -    22484847 chr5:78616003(+) A-G intron -    22484847 chr5:78616274(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	JMY	chr5:78532117-78532118(+) m6A 5'UTR       - chr5:78532217-78532218(+) m6A 5'UTR       - chr5:78532245-78532246(+) m6A 5'UTR       24284625//25456834//24981863//22608085 chr5:78532323-78532324(+) m6A 5'UTR       24284625//25456834//24981863//22608085 chr5:78532507-78532508(+) m6A CDS       24284625//24981863//22608085 chr5:78532550-78532551(+) m6A CDS       24284625//24981863//22608085 chr5:78532581-78532582(+) Gm CDS       - chr5:78532846-78532847(+) m6A CDS       - chr5:78532913-78532914(+) m6A CDS       24284625 chr5:78532932-78532933(+) m6A CDS       24284625 chr5:78533165-78533166(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr5:78533182-78533183(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr5:78533218-78533219(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr5:78533258-78533259(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr5:78533274-78533275(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr5:78533365-78533366(+) m6A CDS       24284625//24981863//22575960 chr5:78533409-78533410(+) m6A CDS       24284625//24981863//22575960 chr5:78573786-78573787(+) Cm CDS       - chr5:78573833-78573834(+) m6A CDS       24981863 chr5:78573865-78573866(+) m6A CDS       24981863 chr5:78573875-78573876(+) m6A CDS       24981863 chr5:78573893-78573894(+) m6A CDS       24981863 chr5:78585969-78585970(+) m6A CDS       24981863 chr5:78596130-78596131(+) m6A CDS//exon       24981863 chr5:78602214-78602215(+) m6A CDS//intron       24981863 chr5:78602263-78602264(+) m6A CDS//intron       24981863//22608085 chr5:78608284-78608285(+) m6A CDS//intron       24981863//22608085 chr5:78608291-78608292(+) m6A CDS//intron       24981863//22608085 chr5:78608302-78608303(+) m6A CDS//intron       24981863//22608085 chr5:78608309-78608310(+) m6A CDS//intron       24981863//22608085 chr5:78608317-78608318(+) m6A CDS//intron       24981863//22608085 chr5:78610214-78610215(+) m6A CDS//intron       24284625//24981863//22608085 chr5:78610259-78610260(+) m6A CDS//intron       24284625//24209618//24981863//22608085 chr5:78610267-78610268(+) m6A CDS//intron       24284625//24209618//24981863//22608085 chr5:78610351-78610352(+) m6A CDS//intron       24284625//24209618//24981863//22608085 chr5:78610396-78610397(+) m6A CDS//intron       24284625//24209618//24981863//22608085 chr5:78610506-78610507(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085 chr5:78610520-78610521(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085 chr5:78610646-78610647(+) m6A CDS//intron       24284625//25456834//24981863//22608085 chr5:78611889-78611890(+) m6A CDS//intron       24284625//24981863//22608085 chr5:78611896-78611897(+) m6A CDS//intron       24284625//24981863//22608085 chr5:78612023-78612024(+) m6A CDS//intron       24284625//24981863//22608085 chr5:78612116-78612117(+) m6A CDS//intron       24284625//24981863//22608085 chr5:78612125-78612126(+) m6A CDS//intron       24284625//24981863//22608085 chr5:78617760-78617761(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr5:78617799-78617800(+) m6A 3'UTR//intron       24284625//25456834//24981863//22575960//22608085 chr5:78617811-78617812(+) m6A 3'UTR//intron       24284625//25456834//24981863//22575960//22608085 chr5:78622083-78622084(+) m6A 3'UTR       27773535 chr5:78622110-78622111(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-29b-3p	Cytoplasm HeLa cells     28185889 Cytoplasm Hepatic carcinoma cells (Huh-7)     29253196 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Urine     26576778 Exosome HCC tissues     30542726 Exosome Saliva     19627513 Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Epithelial cells|Seminal fluid|Tongue tissue     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Hela cells|NIH-3T3 cells     17204650 Nucleus HeLa cells     28185889 Nucleus Hepatic carcinoma cells (Huh-7)     29253196 Nucleus HeLa cells     30006350 Nucleus Nasopharyngeal carcinoma cells     20498841
	JMY	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-29b-3p	Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug resistant Phenyl gallate 333279 Drug resistant N-[(4R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris(3-aminopropoxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentyl]octan-1-amine 24205348 Drug sensitive 8-Hydroxyquinoline 1923 Drug resistant (R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug sensitive Acid Alizarine Red B 135565636 Drug resistant 2-Acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 Drug resistant 1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant 4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug resistant naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)- - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-29b-3p	Formaldehyde 712 Drug interaction    RC00001120 Oxaliplatine 6857599 Drug interaction    RC00001140 Gemcitabine 60750 Drug interaction    RC00001131 Progesterone 5994 Drug interaction    RC00001126 D-Glucose 5793 Drug interaction    RC00001125 Eloxatine 5310940 Drug interaction    RC00001139 Imatinib 5291 Drug interaction    RC00001124 Decitabine 451668 Drug interaction    RC00001137 Docosahexaenoic acid 445580 Drug interaction    RC00001136 Trichostatin A 444732 Drug interaction    RC00001135 Cyclopamine 442972 Drug interaction    RC00001134 Bortezomib 387447 Drug interaction    RC00001133 Etoposide 36462 Drug interaction    RC00001130 Paclitaxel 36314 Drug interaction    RC00001129 5-Fluorouracil 3385 Drug interaction    RC00001123 Enoxacin 3229 Drug interaction    RC00001122 Doxorubicin 31703 Drug interaction    RC00001128 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001121 Tamoxifen 2733526 Drug interaction    RC00001138 Ixazomib 25183872 Drug interaction    RC00001144 Navitoclax 24978538 Drug interaction    RC00001143 Ampligen & InterferonalphaA 16197265 Drug interaction    RC00001142 Leucovorin 135403648 Drug interaction    RC00001145 Ginsenoside Rh2 119307 Drug interaction    RC00001132 Carfilzomib 11556711 Drug interaction    RC00001141 Androstanolone 10635 Drug interaction    RC00001127 Chemotherapy - Drug interaction    RC00001146 5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00001147 Glucocorticoid - Drug interaction    RC00001148 Testosterone + 1,25-Dihydroxyvitamin D3 - Drug interaction    RC00001149 Trastuzumab - Drug interaction    RC00001150

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-29b-3p	Bortezomib 387447       30728351

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-29b-3p
Interactor2: JMY

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).