Detail Information

Basic Information:


  VIRBase ID:  

HHID00003300

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-29b-3p:           IFFO2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-29b-3p IFFO2
miRBase
Accession/Entrez ID		 MIMAT0000100 126917
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-29b-3p
rs868994683 chr7:130877473    G/A
rs1390817128 chr1:207802451    A/G
rs773555186 chr1:207802453    A/C
rs773555186 chr1:207802453    A/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR IFFO2
chr1:19260700(-) A-I      intronic
chr1:19260702(-) A-I      intronic
chr1:19260685(-) A-I      intronic
chr1:19241265(-) A-I      intronic
chr1:19240597(-) A-I      intronic
chr1:19242591(-) A-I      intronic
chr1:19240598(-) A-I      intronic
chr1:19273170(-) A-I      intronic
chr1:19240571(-) A-I      intronic
chr1:19240392(-) A-I      intronic
chr1:19240490(-) A-I      intronic
chr1:19240592(-) A-I      intronic
chr1:19242611(-) A-I      intronic
chr1:19240464(-) A-I      intronic
chr1:19242507(-) A-I      intronic
chr1:19260677(-) A-I      intronic
chr1:19269921(-) A-I      intronic
chr1:19260760(-) A-I      intronic
chr1:19269757(-) A-I      intronic
chr1:19268797(-) A-I      intronic
chr1:19242583(-) A-I      intronic
chr1:19260673(-) A-I      intronic
chr1:19262295(-) A-I      intronic
chr1:19262300(-) A-I      intronic
chr1:19260094(-) A-I      intronic
chr1:19269873(-) A-I      intronic
chr1:19270065(-) A-I      intronic
chr1:19260157(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED IFFO2
chr1:19240464(-) A-G intron -    22484847
chr1:19242611(-) A-G intron -    22484847
chr1:19269757(-) A-G intron -    22484847
chr1:19269873(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IFFO2
chr1:19230976-19230977(-) m6A 3'UTR       27773535
chr1:19231028-19231029(-) m6A 3'UTR       -
chr1:19231080-19231081(-) m6A 3'UTR       -
chr1:19231930-19231931(-) m6A 3'UTR       -
chr1:19232024-19232025(-) m6A 3'UTR       -
chr1:19232067-19232068(-) m6A 3'UTR       -
chr1:19232159-19232160(-) m6A 3'UTR       27773535
chr1:19232166-19232167(-) m6A 3'UTR       27773535
chr1:19232250-19232251(-) m6A 3'UTR       -
chr1:19232276-19232277(-) m6A 3'UTR       -
chr1:19234333-19234334(-) m6A 3'UTR       24981863
chr1:19234338-19234339(-) m6A 3'UTR       24981863
chr1:19234353-19234354(-) m6A 3'UTR       24981863
chr1:19234395-19234396(-) m6A 3'UTR       24981863
chr1:19234440-19234441(-) m6A 3'UTR       24981863
chr1:19234497-19234498(-) m6A 3'UTR       -
chr1:19234697-19234698(-) m6A 3'UTR       24981863//27773535
chr1:19234784-19234785(-) m6A 3'UTR       24284625//24981863//27773535
chr1:19234796-19234797(-) m6A 3'UTR       24284625//24981863//27773535
chr1:19234909-19234910(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//27773536
chr1:19234946-19234947(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//27773536
chr1:19236838-19236839(-) m6A CDS       27371828
chr1:19236869-19236870(-) m6A CDS       27371828
chr1:19236934-19236935(-) m6A CDS       27773535
chr1:19237911-19237912(-) m6A CDS//intron       27773535
chr1:19237936-19237937(-) m6A CDS//intron       27773535
chr1:19237959-19237960(-) m6A CDS//intron       27773535
chr1:19238517-19238518(-) m6A CDS       27773535
chr1:19238569-19238570(-) m6A CDS       24981863//27773535
chr1:19243432-19243433(-) m6A CDS       24981863//27773535
chr1:19243465-19243466(-) m6A CDS       27773535
chr1:19244883-19244884(-) m6A CDS//intron       27773535
chr1:19244940-19244941(-) m6A CDS//intron       24981863//27773535
chr1:19244946-19244947(-) m6A CDS//intron       24981863//27773535
chr1:19244979-19244980(-) m6A CDS//intron       24209618//24981863
chr1:19244985-19244986(-) m6A CDS//intron       24209618//24981863
chr1:19247567-19247568(-) m6A CDS       24209618//24981863//27371828
chr1:19247577-19247578(-) m6A CDS       24209618//24981863//27371828
chr1:19247585-19247586(-) m6A CDS       24209618//24981863//27371828
chr1:19282297-19282298(-) m6A CDS       24209618//27773536
chr1:19282348-19282349(-) m6A CDS       27773536
chr1:19282501-19282502(-) m6A CDS       27773536
chr1:19282528-19282529(-) m6A CDS       27773536
chr1:19282818-19282819(-) m6A CDS       24209618//24981863//27773536
chr1:19282948-19282949(-) m6A 5'UTR       24209618//27371828//27773536
chr1:19283095-19283096(-) m6A 5'UTR       24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-29b-3p
Cytoplasm HeLa cells     28185889
Cytoplasm Hepatic carcinoma cells (Huh-7)     29253196
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Urine     26576778
Exosome HCC tissues     30542726
Exosome Saliva     19627513
Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Epithelial cells|Seminal fluid|Tongue tissue     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Hela cells|NIH-3T3 cells     17204650
Nucleus HeLa cells     28185889
Nucleus Hepatic carcinoma cells (Huh-7)     29253196
Nucleus HeLa cells     30006350
Nucleus Nasopharyngeal carcinoma cells     20498841
IFFO2
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-29b-3p
Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug resistant
Phenyl gallate 333279 Drug resistant
N-[(4R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris(3-aminopropoxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentyl]octan-1-amine 24205348 Drug sensitive
8-Hydroxyquinoline 1923 Drug resistant
(R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug sensitive
Acid Alizarine Red B 135565636 Drug resistant
2-Acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 Drug resistant
1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant
4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug resistant
naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)- - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-29b-3p
Formaldehyde 712 Drug interaction    RC00001120
Oxaliplatine 6857599 Drug interaction    RC00001140
Gemcitabine 60750 Drug interaction    RC00001131
Progesterone 5994 Drug interaction    RC00001126
D-Glucose 5793 Drug interaction    RC00001125
Eloxatine 5310940 Drug interaction    RC00001139
Imatinib 5291 Drug interaction    RC00001124
Decitabine 451668 Drug interaction    RC00001137
Docosahexaenoic acid 445580 Drug interaction    RC00001136
Trichostatin A 444732 Drug interaction    RC00001135
Cyclopamine 442972 Drug interaction    RC00001134
Bortezomib 387447 Drug interaction    RC00001133
Etoposide 36462 Drug interaction    RC00001130
Paclitaxel 36314 Drug interaction    RC00001129
5-Fluorouracil 3385 Drug interaction    RC00001123
Enoxacin 3229 Drug interaction    RC00001122
Doxorubicin 31703 Drug interaction    RC00001128
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001121
Tamoxifen 2733526 Drug interaction    RC00001138
Ixazomib 25183872 Drug interaction    RC00001144
Navitoclax 24978538 Drug interaction    RC00001143
Ampligen & InterferonalphaA 16197265 Drug interaction    RC00001142
Leucovorin 135403648 Drug interaction    RC00001145
Ginsenoside Rh2 119307 Drug interaction    RC00001132
Carfilzomib 11556711 Drug interaction    RC00001141
Androstanolone 10635 Drug interaction    RC00001127
Chemotherapy - Drug interaction    RC00001146
5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00001147
Glucocorticoid - Drug interaction    RC00001148
Testosterone + 1,25-Dihydroxyvitamin D3 - Drug interaction    RC00001149
Trastuzumab - Drug interaction    RC00001150
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-29b-3p
Bortezomib 387447       30728351

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-29b-3p
Interactor2: IFFO2

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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