Detail Information

Basic Information:


  VIRBase ID:  

HHID00003284

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-29b-3p:           SESTD1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-29b-3p SESTD1
miRBase
Accession/Entrez ID		 MIMAT0000100 91404
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - SOLO

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-29b-3p
rs868994683 chr7:130877473    G/A
rs1390817128 chr1:207802451    A/G
rs773555186 chr1:207802453    A/C
rs773555186 chr1:207802453    A/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SESTD1
chr2:180025808(-) A-I      intronic
chr2:180025811(-) A-I      intronic
chr2:180024154(-) A-I      intronic
chr2:180112440(-) A-I      intronic
chr2:180112290(-) A-I      intronic
chr2:180098329(-) A-I      intronic
chr2:180098313(-) A-I      intronic
chr2:180095105(-) A-I      intronic
chr2:180094995(-) A-I      intronic
chr2:180094953(-) A-I      intronic
chr2:180027716(-) A-I      intronic
chr2:180027601(-) A-I      intronic
chr2:180024856(-) A-I      intronic
chr2:180024851(-) A-I      intronic
chr2:180024693(-) A-I      intronic
chr2:180020281(-) A-I      intronic
chr2:180020260(-) A-I      intronic
chr2:180000397(-) A-I      intronic
chr2:180000380(-) A-I      intronic
chr2:179999851(-) A-I      intronic
chr2:179999849(-) A-I      intronic
chr2:179999809(-) A-I      intronic
chr2:179999783(-) A-I      intronic
chr2:179999768(-) A-I      intronic
chr2:179999702(-) A-I      intronic
chr2:179984893(-) A-I      intronic
chr2:180125229(-) A-I      intronic
chr2:180125143(-) A-I      intronic
chr2:180124151(-) A-I      intronic
chr2:180124150(-) A-I      intronic
chr2:180124096(-) A-I      intronic
chr2:180124055(-) A-I      intronic
chr2:180118614(-) A-I      intronic
chr2:180125148(-) A-I      intronic
chr2:180032586(-) A-I      intronic
chr2:180095042(-) A-I      intronic
chr2:180124139(-) A-I      intronic
chr2:180094987(-) A-I      intronic
chr2:180027635(-) A-I      intronic
chr2:180027532(-) A-I      intronic
chr2:179976652(-) A-I      intronic
chr2:180020248(-) A-I      intronic
chr2:180109847(-) A-I      intronic
chr2:179999854(-) A-I      intronic
chr2:180109932(-) A-I      intronic
chr2:180124130(-) A-I      intronic
chr2:180000246(-) A-I      intronic
chr2:180025922(-) A-I      intronic
chr2:179999860(-) A-I      intronic
chr2:180112442(-) A-I      intronic
chr2:179976611(-) A-I      intronic
chr2:180000385(-) A-I      intronic
chr2:180019838(-) A-I      intronic
chr2:180027464(-) A-I      intronic
chr2:180000466(-) A-I      intronic
chr2:180095027(-) A-I      intronic
chr2:180124069(-) A-I      intronic
chr2:180098318(-) A-I      intronic
chr2:180094965(-) A-I      intronic
chr2:180025764(-) A-I      intronic
chr2:180025799(-) A-I      intronic
chr2:180112386(-) A-I      intronic
chr2:180000474(-) A-I      intronic
chr2:180019737(-) A-I      intronic
chr2:180095136(-) A-I      intronic
chr2:180000396(-) A-I      intronic
chr2:180025915(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SESTD1
chr2:179999854(-) A-G intron -    22484847
chr2:179999860(-) A-G intron -    22484847
chr2:180000385(-) A-G intron -    22484847
chr2:180000386(-) A-G intron -    22484847
chr2:180000396(-) A-G intron -    22484847
chr2:180027606(-) A-G intron -    22484847
chr2:180124139(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SESTD1
chr2:179966476-179966477(-) m6A 3'UTR       27773535
chr2:179966487-179966488(-) m6A 3'UTR       27773535
chr2:179966560-179966561(-) m6A 3'UTR       27773535
chr2:179967559-179967560(-) m6A 3'UTR       27773535
chr2:179969511-179969512(-) m6A 3'UTR       27773535
chr2:179969568-179969569(-) m6A 3'UTR       27773535
chr2:179969577-179969578(-) m6A 3'UTR       27773535
chr2:179969593-179969594(-) m6A 3'UTR       27773535
chr2:179969602-179969603(-) m6A 3'UTR       27773535
chr2:179969614-179969615(-) m6A 3'UTR       27773535
chr2:179969646-179969647(-) m6A 3'UTR       27773535
chr2:179969666-179969667(-) m6A 3'UTR       27773535
chr2:179969731-179969732(-) m6A 3'UTR       27773535
chr2:179969771-179969772(-) m6A 3'UTR       27773535
chr2:179969778-179969779(-) m6A 3'UTR       27773535
chr2:179969817-179969818(-) m6A 3'UTR       24981863//27773535
chr2:179969836-179969837(-) m6A 3'UTR       24981863//27773535
chr2:179969884-179969885(-) m6A 3'UTR       24981863//27773535
chr2:179969899-179969900(-) m6A 3'UTR       24981863//27773535
chr2:179969904-179969905(-) m6A 3'UTR       24981863//27773535
chr2:179969966-179969967(-) m6A 3'UTR       24981863//27773535
chr2:179970028-179970029(-) m6A 3'UTR       27773535
chr2:179970088-179970089(-) m6A 3'UTR       27773535
chr2:179970103-179970104(-) m6A 3'UTR       27773535
chr2:179973139-179973140(-) m6A 3'UTR       27773535
chr2:179973180-179973181(-) m6A 3'UTR       27773535
chr2:179973325-179973326(-) m6A 3'UTR       27773535
chr2:179973358-179973359(-) m6A 3'UTR       27773535
chr2:179974655-179974656(-) m6A 3'UTR//CDS       27371828
chr2:179974685-179974686(-) m6A 3'UTR//CDS       27371828
chr2:179974695-179974696(-) m6A 3'UTR//CDS       27371828
chr2:179974704-179974705(-) m6A 3'UTR//CDS       27371828
chr2:179974748-179974749(-) m6A 3'UTR//CDS       27371828
chr2:179997091-179997092(-) m6A CDS//exon//intron       24981863
chr2:179997120-179997121(-) m6A CDS//exon//intron       24981863
chr2:179997145-179997146(-) m6A CDS//exon//intron       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-29b-3p
Cytoplasm HeLa cells     28185889
Cytoplasm Hepatic carcinoma cells (Huh-7)     29253196
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Urine     26576778
Exosome HCC tissues     30542726
Exosome Saliva     19627513
Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Epithelial cells|Seminal fluid|Tongue tissue     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Hela cells|NIH-3T3 cells     17204650
Nucleus HeLa cells     28185889
Nucleus Hepatic carcinoma cells (Huh-7)     29253196
Nucleus HeLa cells     30006350
Nucleus Nasopharyngeal carcinoma cells     20498841
SESTD1
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-29b-3p
Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug resistant
Phenyl gallate 333279 Drug resistant
N-[(4R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris(3-aminopropoxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentyl]octan-1-amine 24205348 Drug sensitive
8-Hydroxyquinoline 1923 Drug resistant
(R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug sensitive
Acid Alizarine Red B 135565636 Drug resistant
2-Acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 Drug resistant
1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant
4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug resistant
naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)- - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-29b-3p
Formaldehyde 712 Drug interaction    RC00001120
Oxaliplatine 6857599 Drug interaction    RC00001140
Gemcitabine 60750 Drug interaction    RC00001131
Progesterone 5994 Drug interaction    RC00001126
D-Glucose 5793 Drug interaction    RC00001125
Eloxatine 5310940 Drug interaction    RC00001139
Imatinib 5291 Drug interaction    RC00001124
Decitabine 451668 Drug interaction    RC00001137
Docosahexaenoic acid 445580 Drug interaction    RC00001136
Trichostatin A 444732 Drug interaction    RC00001135
Cyclopamine 442972 Drug interaction    RC00001134
Bortezomib 387447 Drug interaction    RC00001133
Etoposide 36462 Drug interaction    RC00001130
Paclitaxel 36314 Drug interaction    RC00001129
5-Fluorouracil 3385 Drug interaction    RC00001123
Enoxacin 3229 Drug interaction    RC00001122
Doxorubicin 31703 Drug interaction    RC00001128
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001121
Tamoxifen 2733526 Drug interaction    RC00001138
Ixazomib 25183872 Drug interaction    RC00001144
Navitoclax 24978538 Drug interaction    RC00001143
Ampligen & InterferonalphaA 16197265 Drug interaction    RC00001142
Leucovorin 135403648 Drug interaction    RC00001145
Ginsenoside Rh2 119307 Drug interaction    RC00001132
Carfilzomib 11556711 Drug interaction    RC00001141
Androstanolone 10635 Drug interaction    RC00001127
Chemotherapy - Drug interaction    RC00001146
5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00001147
Glucocorticoid - Drug interaction    RC00001148
Testosterone + 1,25-Dihydroxyvitamin D3 - Drug interaction    RC00001149
Trastuzumab - Drug interaction    RC00001150
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-29b-3p
Bortezomib 387447       30728351

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-29b-3p
Interactor2: SESTD1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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