Basic Information:

  VIRBase ID:  

HHID00003130

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-29b-3p:  MIMAT0000100          PAIP2:  NR_109830     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-29b-3p	PAIP2
miRBase Accession/Entrez ID	MIMAT0000100	51247
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	PAIP-2//PAIP2A

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-29b-3p	rs868994683 chr7:130877473    G/A rs1390817128 chr1:207802451    A/G rs773555186 chr1:207802453    A/C rs773555186 chr1:207802453    A/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PAIP2	chr5:138682516(+) A-I      intronic chr5:138698705(+) A-I      intronic chr5:138698796(+) A-I      intronic chr5:138698890(+) A-I      intronic chr5:138699160(+) A-I      intronic chr5:138699251(+) A-I      intronic chr5:138699253(+) A-I      intronic chr5:138699284(+) A-I      intronic chr5:138699337(+) A-I      intronic chr5:138700605(+) A-I      intronic chr5:138700644(+) A-I      intronic chr5:138700683(+) A-I      intronic chr5:138700686(+) A-I      intronic chr5:138700699(+) A-I      intronic chr5:138700722(+) A-I      intronic chr5:138680755(+) A-I      intronic chr5:138699352(+) A-I      intronic chr5:138698880(+) A-I      intronic chr5:138698450(+) A-I      intronic chr5:138682201(+) A-I      intronic chr5:138683163(+) A-I      intronic chr5:138683611(+) A-I      intronic chr5:138683677(+) A-I      intronic chr5:138698422(+) A-I      intronic chr5:138695049(+) A-I      intronic chr5:138683736(+) A-I      intronic chr5:138683805(+) A-I      intronic chr5:138683933(+) A-I      intronic chr5:138684113(+) A-I      intronic chr5:138684228(+) A-I      intronic chr5:138684267(+) A-I      intronic chr5:138684579(+) A-I      intronic chr5:138695037(+) A-I      intronic chr5:138695017(+) A-I      intronic chr5:138684617(+) A-I      intronic chr5:138685018(+) A-I      intronic chr5:138685188(+) A-I      intronic chr5:138685429(+) A-I      intronic chr5:138685477(+) A-I      intronic chr5:138685606(+) A-I      intronic chr5:138686139(+) A-I      intronic chr5:138687412(+) A-I      intronic chr5:138687447(+) A-I      intronic chr5:138700763(+) A-I      intronic chr5:138687509(+) A-I      intronic chr5:138688381(+) A-I      intronic chr5:138693445(+) A-I      intronic chr5:138693452(+) A-I      intronic chr5:138694965(+) A-I      intronic chr5:138695813(+) A-I      intronic chr5:138696519(+) A-I      intronic chr5:138696520(+) A-I      intronic chr5:138700974(+) A-I      intronic chr5:138700989(+) A-I      intronic chr5:138701188(+) A-I      intronic chr5:138695008(+) A-I      intronic chr5:138703651(+) A-I      intronic chr5:138687474(+) A-I      intronic chr5:138698373(+) A-I      intronic chr5:138696619(+) A-I      intronic chr5:138696708(+) A-I      intronic chr5:138696740(+) A-I      intronic chr5:138697370(+) A-I      intronic chr5:138697378(+) A-I      intronic chr5:138697499(+) A-I      intronic chr5:138697644(+) A-I      intronic chr5:138698239(+) A-I      intronic chr5:138698430(+) A-I      intronic chr5:138698464(+) A-I      intronic chr5:138698509(+) A-I      intronic chr5:138698696(+) A-I      intronic chr5:138681337(+) A-I      intronic chr5:138684991(+) A-I      intronic chr5:138682401(+) A-I      intronic chr5:138695541(+) A-I      intronic chr5:138696307(+) A-I      intronic chr5:138699250(+) A-I      intronic chr5:138683606(+) A-I      intronic chr5:138683165(+) A-I      intronic chr5:138695473(+) A-I      intronic chr5:138696262(+) A-I      intronic chr5:138683665(+) A-I      intronic chr5:138682981(+) A-I      intronic chr5:138685431(+) A-I      intronic chr5:138688550(+) A-I      intronic chr5:138695481(+) A-I      intronic chr5:138685580(+) A-I      intronic chr5:138699247(+) A-I      intronic chr5:138693483(+) A-I      intronic chr5:138696563(+) A-I      intronic chr5:138680935(+) A-I      intronic chr5:138685576(+) A-I      intronic chr5:138686173(+) A-I      intronic chr5:138682766(+) A-I      intronic chr5:138695915(+) A-I      intronic chr5:138695893(+) A-I      intronic chr5:138688591(+) A-I      intronic chr5:138683092(+) A-I      intronic chr5:138698039(+) A-I      intronic chr5:138683814(+) A-I      intronic chr5:138683675(+) A-I      intronic chr5:138696609(+) A-I      intronic chr5:138698849(+) A-I      intronic chr5:138688440(+) A-I      intronic chr5:138695550(+) A-I      intronic chr5:138698680(+) A-I      intronic chr5:138686141(+) A-I      intronic chr5:138682272(+) A-I      intronic chr5:138685437(+) A-I      intronic chr5:138693804(+) A-I      intronic chr5:138687436(+) A-I      intronic chr5:138679612(+) A-I      intronic chr5:138685216(+) A-I      intronic chr5:138686133(+) A-I      intronic chr5:138695858(+) A-I      intronic chr5:138679571(+) A-I      intronic chr5:138699190(+) A-I      intronic chr5:138685118(+) A-I      intronic chr5:138680990(+) A-I      intronic chr5:138694912(+) A-I      intronic chr5:138694991(+) A-I      intronic chr5:138696354(+) A-I      intronic chr5:138699318(+) A-I      intronic chr5:138693426(+) A-I      intronic chr5:138685532(+) A-I      intronic chr5:138682568(+) A-I      intronic chr5:138685847(+) A-I      intronic chr5:138698674(+) A-I      intronic chr5:138696733(+) A-I      intronic chr5:138699241(+) A-I      intronic chr5:138684957(+) A-I      intronic chr5:138685544(+) A-I      intronic chr5:138695617(+) A-I      intronic chr5:138695916(+) A-I      intronic chr5:138685703(+) A-I      intronic chr5:138683182(+) A-I      intronic chr5:138693399(+) A-I      intronic chr5:138699290(+) A-I      intronic chr5:138697524(+) A-I      intronic chr5:138682674(+) A-I      intronic chr5:138683605(+) A-I      intronic chr5:138687489(+) A-I      intronic chr5:138682628(+) A-I      intronic chr5:138679590(+) A-I      intronic chr5:138695048(+) A-I      intronic chr5:138696732(+) A-I      intronic chr5:138688619(+) A-I      intronic chr5:138697547(+) A-I      intronic chr5:138696311(+) A-I      intronic chr5:138699255(+) A-I      intronic chr5:138696205(+) A-I      intronic chr5:138692320(+) A-I      intronic chr5:138688685(+) A-I      intronic chr5:138682290(+) A-I      intronic chr5:138695115(+) A-I      intronic chr5:138685482(+) A-I      intronic chr5:138687549(+) A-I      intronic chr5:138688654(+) A-I      intronic chr5:138685464(+) A-I      intronic chr5:138698879(+) A-I      intronic chr5:138684308(+) A-I      intronic chr5:138684587(+) A-I      intronic chr5:138695839(+) A-I      intronic chr5:138697515(+) A-I      intronic chr5:138688300(+) A-I      intronic chr5:138682363(+) A-I      intronic chr5:138682350(+) A-I      intronic chr5:138683628(+) A-I      intronic chr5:138685744(+) A-I      intronic chr5:138696294(+) A-I      intronic chr5:138685540(+) A-I      intronic chr5:138685539(+) A-I      intronic chr5:138699349(+) A-I      intronic chr5:138688558(+) A-I      intronic chr5:138695821(+) A-I      intronic chr5:138688551(+) A-I      intronic chr5:138682199(+) A-I      intronic chr5:138698925(+) A-I      intronic chr5:138685071(+) A-I      intronic chr5:138690587(+) A-I      intronic chr5:138695592(+) A-I      intronic chr5:138697487(+) A-I      intronic chr5:138683747(+) A-I      intronic chr5:138695011(+) A-I      intronic chr5:138698675(+) A-I      intronic chr5:138679472(+) A-I      intronic chr5:138685630(+) A-I      intronic chr5:138696599(+) A-I      intronic chr5:138698490(+) A-I      intronic chr5:138684231(+) A-I      intronic chr5:138690776(+) A-I      intronic chr5:138698472(+) A-I      intronic chr5:138685490(+) A-I      intronic chr5:138690609(+) A-I      intronic chr5:138694745(+) A-I      intronic chr5:138683198(+) A-I      intronic chr5:138698014(+) A-I      intronic chr5:138697384(+) A-I      intronic chr5:138691395(+) A-I      intronic chr5:138680939(+) A-I      intronic chr5:138699152(+) A-I      intronic chr5:138687514(+) A-I      intronic chr5:138682733(+) A-I      intronic chr5:138698463(+) A-I      intronic chr5:138686239(+) A-I      intronic chr5:138698850(+) A-I      intronic chr5:138681523(+) A-I      intronic chr5:138683714(+) A-I      intronic chr5:138683660(+) A-I      intronic chr5:138696366(+) A-I      intronic chr5:138696587(+) A-I      intronic chr5:138697379(+) A-I      intronic chr5:138698449(+) A-I      intronic chr5:138683957(+) A-I      intronic chr5:138682741(+) A-I      intronic chr5:138688684(+) A-I      intronic chr5:138696308(+) A-I      intronic chr5:138691667(+) A-I      intronic chr5:138692387(+) A-I      intronic chr5:138685538(+) A-I      intronic chr5:138695581(+) A-I      intronic chr5:138693361(+) A-I      intronic chr5:138685848(+) A-I      intronic chr5:138684253(+) A-I      intronic chr5:138699300(+) A-I      intronic chr5:138695928(+) A-I      intronic chr5:138688571(+) A-I      intronic chr5:138698416(+) A-I      intronic chr5:138683685(+) A-I      intronic chr5:138683794(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PAIP2	chr5:138682290(+) A-G intron -    22484847 chr5:138682568(+) A-G intron -    22484847 chr5:138682628(+) A-G intron -    22484847 chr5:138682741(+) A-G intron -    22484847 chr5:138682766(+) A-G intron -    22484847 chr5:138683165(+) A-G intron -    22484847 chr5:138683660(+) A-G intron -    22484847 chr5:138683747(+) A-G intron -    22484847 chr5:138685071(+) A-G intron -    22484847 chr5:138685147(+) A-G intron -    22484847 chr5:138685431(+) A-G intron -    22484847 chr5:138685576(+) A-G intron -    22484847 chr5:138688300(+) A-G intron -    22484847 chr5:138688649(+) T-C intron -    22484847 chr5:138688684(+) A-G intron -    22484847 chr5:138688685(+) A-G intron -    22484847 chr5:138689425(+) A-T intron -    22484847 chr5:138689427(+) G-A intron -    22484847 chr5:138692382(+) A-G intron -    22484847 chr5:138694771(+) T-C intron -    22484847 chr5:138695048(+) A-G intron -    22484847 chr5:138695592(+) A-G intron -    22484847 chr5:138695742(+) A-G intron -    22484847 chr5:138695821(+) A-G intron -    22484847 chr5:138696669(+) T-C intron -    22484847 chr5:138696702(+) T-C intron -    22484847 chr5:138697437(+) T-C intron -    22484847 chr5:138697552(+) T-C intron -    22484847 chr5:138698449(+) A-G intron -    22484847 chr5:138698876(+) A-G intron -    22484847 chr5:138699349(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PAIP2	chr5:138677489-138677490(+) m6A 5'UTR       25456834//24981863 chr5:138677552-138677553(+) m6A 5'UTR//exon       25456834//24981863 chr5:138678159-138678160(+) m6A 5'UTR//intron       24981863 chr5:138679083-138679084(+) m6A 5'UTR//exon//intron       24981863 chr5:138699607-138699608(+) m6A CDS//exon//intron       24981863//27773535 chr5:138699628-138699629(+) m6A exon//intron       24981863//27773535 chr5:138699718-138699719(+) m6A exon//intron       24981863//27773535 chr5:138700312-138700313(+) Gm CDS//exon//intron       - chr5:138700360-138700361(+) m6A CDS//exon//intron       24981863//26404942//27773535 chr5:138700367-138700368(+) m6A CDS//exon//intron       24981863//26404942//27773535 chr5:138700379-138700380(+) m6A CDS//exon//intron       24981863//26404942//27773535 chr5:138700753-138700754(+) m6A exon//intron       - chr5:138705172-138705173(+) m6A 3'UTR       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-29b-3p	Cytoplasm HeLa cells     28185889 Cytoplasm Hepatic carcinoma cells (Huh-7)     29253196 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Urine     26576778 Exosome HCC tissues     30542726 Exosome Saliva     19627513 Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Epithelial cells|Seminal fluid|Tongue tissue     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Hela cells|NIH-3T3 cells     17204650 Nucleus HeLa cells     28185889 Nucleus Hepatic carcinoma cells (Huh-7)     29253196 Nucleus HeLa cells     30006350 Nucleus Nasopharyngeal carcinoma cells     20498841
	PAIP2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-29b-3p	Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug resistant Phenyl gallate 333279 Drug resistant N-[(4R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris(3-aminopropoxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentyl]octan-1-amine 24205348 Drug sensitive 8-Hydroxyquinoline 1923 Drug resistant (R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug sensitive Acid Alizarine Red B 135565636 Drug resistant 2-Acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 Drug resistant 1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant 4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug resistant naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)- - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-29b-3p	Formaldehyde 712 Drug interaction    RC00001120 Oxaliplatine 6857599 Drug interaction    RC00001140 Gemcitabine 60750 Drug interaction    RC00001131 Progesterone 5994 Drug interaction    RC00001126 D-Glucose 5793 Drug interaction    RC00001125 Eloxatine 5310940 Drug interaction    RC00001139 Imatinib 5291 Drug interaction    RC00001124 Decitabine 451668 Drug interaction    RC00001137 Docosahexaenoic acid 445580 Drug interaction    RC00001136 Trichostatin A 444732 Drug interaction    RC00001135 Cyclopamine 442972 Drug interaction    RC00001134 Bortezomib 387447 Drug interaction    RC00001133 Etoposide 36462 Drug interaction    RC00001130 Paclitaxel 36314 Drug interaction    RC00001129 5-Fluorouracil 3385 Drug interaction    RC00001123 Enoxacin 3229 Drug interaction    RC00001122 Doxorubicin 31703 Drug interaction    RC00001128 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001121 Tamoxifen 2733526 Drug interaction    RC00001138 Ixazomib 25183872 Drug interaction    RC00001144 Navitoclax 24978538 Drug interaction    RC00001143 Ampligen & InterferonalphaA 16197265 Drug interaction    RC00001142 Leucovorin 135403648 Drug interaction    RC00001145 Ginsenoside Rh2 119307 Drug interaction    RC00001132 Carfilzomib 11556711 Drug interaction    RC00001141 Androstanolone 10635 Drug interaction    RC00001127 Chemotherapy - Drug interaction    RC00001146 5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00001147 Glucocorticoid - Drug interaction    RC00001148 Testosterone + 1,25-Dihydroxyvitamin D3 - Drug interaction    RC00001149 Trastuzumab - Drug interaction    RC00001150

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-29b-3p	Bortezomib 387447       30728351

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-29b-3p
Interactor2: PAIP2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).