Detail Information

Basic Information:


  VIRBase ID:  

HHID00003122

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-29b-3p:           SENP1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-29b-3p SENP1
miRBase
Accession/Entrez ID		 MIMAT0000100 29843
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - SuPr-2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-29b-3p
rs868994683 chr7:130877473    G/A
rs1390817128 chr1:207802451    A/G
rs773555186 chr1:207802453    A/C
rs773555186 chr1:207802453    A/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SENP1
chr12:48485041(-) A-I      intronic
chr12:48488363(-) A-I      intronic
chr12:48488347(-) A-I      intronic
chr12:48487940(-) A-I      intronic
chr12:48487654(-) A-I      intronic
chr12:48487334(-) A-I      intronic
chr12:48448534(-) A-I      intronic
chr12:48487333(-) A-I      intronic
chr12:48487290(-) A-I      intronic
chr12:48487159(-) A-I      intronic
chr12:48485559(-) A-I      intronic
chr12:48485538(-) A-I      intronic
chr12:48485509(-) A-I      intronic
chr12:48485069(-) A-I      intronic
chr12:48485066(-) A-I      intronic
chr12:48476861(-) A-I      intronic
chr12:48468771(-) A-I      intronic
chr12:48461804(-) A-I      intronic
chr12:48461512(-) A-I      intronic
chr12:48485084(-) A-I      intronic
chr12:48497894(-) A-I      intronic
chr12:48492202(-) A-I      intronic
chr12:48488377(-) A-I      intronic
chr12:48487914(-) A-I      intronic
chr12:48485121(-) A-I      intronic
chr12:48488441(-) A-I      intronic
chr12:48488341(-) A-I      intronic
chr12:48451216(-) A-I      intronic
chr12:48487924(-) A-I      intronic
chr12:48448316(-) A-I      intronic
chr12:48487339(-) A-I      intronic
chr12:48487205(-) A-I      intronic
chr12:48485696(-) A-I      intronic
chr12:48490691(-) A-I      intronic
chr12:48464645(-) A-I      intronic
chr12:48460309(-) A-I      intronic
chr12:48481974(-) A-I      intronic
chr12:48468779(-) A-I      intronic
chr12:48487318(-) A-I      intronic
chr12:48461498(-) A-I      intronic
chr12:48460472(-) A-I      intronic
chr12:48488087(-) A-I      intronic
chr12:48485582(-) A-I      intronic
chr12:48487294(-) A-I      intronic
chr12:48489219(-) A-I      intronic
chr12:48487195(-) A-I      intronic
chr12:48447039(-) A-I      intronic
chr12:48475432(-) A-I      intronic
chr12:48451675(-) A-I      intronic
chr12:48489109(-) A-I      intronic
chr12:48487187(-) A-I      intronic
chr12:48470564(-) A-I      intronic
chr12:48468887(-) A-I      intronic
chr12:48487204(-) A-I      intronic
chr12:48455288(-) A-I      intronic
chr12:48448314(-) A-I      intronic
chr12:48485667(-) A-I      intronic
chr12:48476963(-) A-I      intronic
chr12:48487175(-) A-I      intronic
chr12:48460296(-) A-I      intronic
chr12:48487955(-) A-I      intronic
chr12:48479422(-) A-I      intronic
chr12:48454425(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SENP1
chr12:48448314(-) A-G intron -    22484847
chr12:48468779(-) A-G intron -    22484847
chr12:48476963(-) A-G intron -    22484847
chr12:48487175(-) A-G intron -    22484847
chr12:48487187(-) A-G intron -    22484847
chr12:48487204(-) A-G intron -    22484847
chr12:48487205(-) A-G intron -    22484847
chr12:48487294(-) A-G intron -    22484847
chr12:48487318(-) A-G intron -    22484847
chr12:48487914(-) A-G intron -    22484847
chr12:48488087(-) A-G intron -    22484847
chr12:48488441(-) A-G intron -    22484847
chr12:48489219(-) A-G intron -    22484847
chr12:48489318(-) G-T intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SENP1
chr12:48437188-48437189(-) m6A 3'UTR       24981863
chr12:48437203-48437204(-) m6A 3'UTR       24981863
chr12:48437872-48437873(-) m6A 3'UTR       24981863
chr12:48437895-48437896(-) m6A 3'UTR       24981863
chr12:48437968-48437969(-) m6A 3'UTR       24981863
chr12:48438002-48438003(-) m6A 3'UTR       24981863
chr12:48438362-48438363(-) m6A 3'UTR       27773535
chr12:48438440-48438441(-) m6A 3'UTR       27773535
chr12:48438547-48438548(-) m6A 3'UTR       27773535
chr12:48438582-48438583(-) m6A 3'UTR       27773535
chr12:48438587-48438588(-) m6A 3'UTR       27773535
chr12:48438639-48438640(-) m6A 3'UTR       24981863//27773535
chr12:48438665-48438666(-) m6A 3'UTR       27773535
chr12:48438684-48438685(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr12:48438784-48438785(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr12:48438858-48438859(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr12:48438881-48438882(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr12:48438908-48438909(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr12:48438984-48438985(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr12:48439029-48439030(-) m6A 3'UTR       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr12:48439038-48439039(-) m6A 3'UTR       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr12:48439066-48439067(-) m6A 3'UTR       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr12:48439084-48439085(-) m6A 3'UTR       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr12:48439101-48439102(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085
chr12:48439113-48439114(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr12:48440156-48440157(-) m6A 3'UTR//CDS       24284625//24981863
chr12:48440160-48440161(-) m6A 3'UTR//CDS       24209618//24981863
chr12:48448689-48448690(-) m6A intron       27773535
chr12:48448800-48448801(-) m6A intron       24284625//24981863//27773535//22575960//22608085
chr12:48448841-48448842(-) m6A intron       24284625//24981863//27773535//22575960//22608085
chr12:48448894-48448895(-) m6A intron       24284625//24981863//27773535//22575960//22608085
chr12:48449029-48449030(-) m6A intron       24284625//27773535//22608085
chr12:48449225-48449226(-) m6A intron       24284625//25456834//27773535//22608085
chr12:48468257-48468258(-) m6A 3'UTR//CDS       27773535
chr12:48468351-48468352(-) m6A 3'UTR//CDS       24981863
chr12:48468498-48468499(-) m6A 3'UTR//CDS       24981863
chr12:48468516-48468517(-) m6A 3'UTR//CDS       24981863
chr12:48468543-48468544(-) m6A 3'UTR//CDS       24981863
chr12:48499548-48499549(-) m6A 5'UTR//intron       27773536
chr12:48499840-48499841(-) m6A 5'UTR//exon       27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-29b-3p
Cytoplasm HeLa cells     28185889
Cytoplasm Hepatic carcinoma cells (Huh-7)     29253196
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Urine     26576778
Exosome HCC tissues     30542726
Exosome Saliva     19627513
Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Epithelial cells|Seminal fluid|Tongue tissue     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Hela cells|NIH-3T3 cells     17204650
Nucleus HeLa cells     28185889
Nucleus Hepatic carcinoma cells (Huh-7)     29253196
Nucleus HeLa cells     30006350
Nucleus Nasopharyngeal carcinoma cells     20498841
SENP1
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome-free cytosol Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-29b-3p
Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug resistant
Phenyl gallate 333279 Drug resistant
N-[(4R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris(3-aminopropoxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentyl]octan-1-amine 24205348 Drug sensitive
8-Hydroxyquinoline 1923 Drug resistant
(R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug sensitive
Acid Alizarine Red B 135565636 Drug resistant
2-Acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 Drug resistant
1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant
4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug resistant
naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)- - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-29b-3p
Formaldehyde 712 Drug interaction    RC00001120
Oxaliplatine 6857599 Drug interaction    RC00001140
Gemcitabine 60750 Drug interaction    RC00001131
Progesterone 5994 Drug interaction    RC00001126
D-Glucose 5793 Drug interaction    RC00001125
Eloxatine 5310940 Drug interaction    RC00001139
Imatinib 5291 Drug interaction    RC00001124
Decitabine 451668 Drug interaction    RC00001137
Docosahexaenoic acid 445580 Drug interaction    RC00001136
Trichostatin A 444732 Drug interaction    RC00001135
Cyclopamine 442972 Drug interaction    RC00001134
Bortezomib 387447 Drug interaction    RC00001133
Etoposide 36462 Drug interaction    RC00001130
Paclitaxel 36314 Drug interaction    RC00001129
5-Fluorouracil 3385 Drug interaction    RC00001123
Enoxacin 3229 Drug interaction    RC00001122
Doxorubicin 31703 Drug interaction    RC00001128
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001121
Tamoxifen 2733526 Drug interaction    RC00001138
Ixazomib 25183872 Drug interaction    RC00001144
Navitoclax 24978538 Drug interaction    RC00001143
Ampligen & InterferonalphaA 16197265 Drug interaction    RC00001142
Leucovorin 135403648 Drug interaction    RC00001145
Ginsenoside Rh2 119307 Drug interaction    RC00001132
Carfilzomib 11556711 Drug interaction    RC00001141
Androstanolone 10635 Drug interaction    RC00001127
Chemotherapy - Drug interaction    RC00001146
5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00001147
Glucocorticoid - Drug interaction    RC00001148
Testosterone + 1,25-Dihydroxyvitamin D3 - Drug interaction    RC00001149
Trastuzumab - Drug interaction    RC00001150
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-29b-3p
Bortezomib 387447       30728351

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-29b-3p
Interactor2: SENP1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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