Basic Information:

  VIRBase ID:  

HHID00003098

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-29b-3p:  MIMAT0000100          CBX5:  NM_001127321     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-29b-3p	CBX5
miRBase Accession/Entrez ID	MIMAT0000100	23468
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HEL25//HP1//HP1A

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-29b-3p	rs868994683 chr7:130877473    G/A rs1390817128 chr1:207802451    A/G rs773555186 chr1:207802453    A/C rs773555186 chr1:207802453    A/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CBX5	chr12:54637993(-) A-I      intronic chr12:54636832(-) A-I      intronic chr12:54636831(-) A-I      intronic chr12:54636813(-) A-I      intronic chr12:54670902(-) A-I      intronic chr12:54668556(-) A-I      intronic chr12:54647139(-) A-I      intronic chr12:54638025(-) A-I      intronic chr12:54638022(-) A-I      intronic chr12:54638017(-) A-I      intronic chr12:54638009(-) A-I      intronic chr12:54641056(-) A-I      intronic chr12:54641510(-) A-I      intronic chr12:54641654(-) A-I      intronic chr12:54641966(-) A-I      intronic chr12:54647762(-) A-I      intronic chr12:54647784(-) A-I      intronic chr12:54658016(-) A-I      intronic chr12:54658192(-) A-I      intronic chr12:54661428(-) A-I      intronic chr12:54639076(-) A-I      intronic chr12:54661815(-) A-I      intronic chr12:54661889(-) A-I      intronic chr12:54662833(-) A-I      intronic chr12:54662994(-) A-I      intronic chr12:54663001(-) A-I      intronic chr12:54663645(-) A-I      intronic chr12:54664579(-) A-I      intronic chr12:54664591(-) A-I      intronic chr12:54661424(-) A-I      intronic chr12:54637541(-) A-I      intronic chr12:54664592(-) A-I      intronic chr12:54637544(-) A-I      intronic chr12:54637560(-) A-I      intronic chr12:54664780(-) A-I      intronic chr12:54637577(-) A-I      intronic chr12:54665139(-) A-I      intronic chr12:54638068(-) A-I      intronic chr12:54638069(-) A-I      intronic chr12:54665167(-) A-I      intronic chr12:54665216(-) A-I      intronic chr12:54671394(-) A-I      intronic chr12:54638339(-) A-I      intronic chr12:54668467(-) A-I      intronic chr12:54671326(-) A-I      intronic chr12:54671325(-) A-I      intronic chr12:54638390(-) A-I      intronic chr12:54638400(-) A-I      intronic chr12:54638410(-) A-I      intronic chr12:54669545(-) A-I      intronic chr12:54669533(-) A-I      intronic chr12:54664759(-) A-I      intronic chr12:54669292(-) A-I      intronic chr12:54638963(-) A-I      intronic chr12:54669147(-) A-I      intronic chr12:54639061(-) A-I      intronic chr12:54639068(-) A-I      intronic chr12:54669087(-) A-I      intronic chr12:54669039(-) A-I      intronic chr12:54668686(-) A-I      intronic chr12:54668677(-) A-I      intronic chr12:54668641(-) A-I      intronic chr12:54668596(-) A-I      intronic chr12:54668565(-) A-I      intronic chr12:54668518(-) A-I      intronic chr12:54637567(-) A-I      intronic chr12:54647728(-) A-I      intronic chr12:54665248(-) A-I      intronic chr12:54663000(-) A-I      intronic chr12:54641279(-) A-I      intronic chr12:54647807(-) A-I      intronic chr12:54657663(-) A-I      intronic chr12:54638924(-) A-I      intronic chr12:54664323(-) A-I      intronic chr12:54671080(-) A-I      intronic chr12:54661745(-) A-I      intronic chr12:54663343(-) A-I      intronic chr12:54639022(-) A-I      intronic chr12:54669662(-) A-I      intronic chr12:54665247(-) A-I      intronic chr12:54643071(-) A-I      intronic chr12:54669154(-) A-I      intronic chr12:54647014(-) A-I      intronic chr12:54658140(-) A-I      intronic chr12:54668612(-) A-I      intronic chr12:54640531(-) A-I      intronic chr12:54671322(-) A-I      intronic chr12:54657106(-) A-I      intronic chr12:54658055(-) A-I      intronic chr12:54669158(-) A-I      intronic chr12:54669298(-) A-I      intronic chr12:54647396(-) A-I      intronic chr12:54634275(-) A-I      3'UTR chr12:54627480(-) A-I      3'UTR chr12:54634214(-) A-I      3'UTR chr12:54627440(-) A-I      3'UTR chr12:54631971(-) A-I      3'UTR chr12:54631836(-) A-I      3'UTR chr12:54627654(-) A-I      3'UTR chr12:54627543(-) A-I      3'UTR chr12:54631746(-) A-I      3'UTR chr12:54629335(-) A-I      3'UTR chr12:54634238(-) A-I      3'UTR chr12:54627640(-) A-I      3'UTR chr12:54634182(-) A-I      3'UTR chr12:54634236(-) A-I      3'UTR chr12:54631892(-) A-I      3'UTR chr12:54669137(-) A-I      intronic chr12:54664297(-) A-I      intronic chr12:54643091(-) A-I      intronic chr12:54664670(-) A-I      intronic chr12:54664198(-) A-I      intronic chr12:54641077(-) A-I      intronic chr12:54659648(-) A-I      intronic chr12:54638491(-) A-I      intronic chr12:54658505(-) A-I      intronic chr12:54657727(-) A-I      intronic chr12:54668575(-) A-I      intronic chr12:54669297(-) A-I      intronic chr12:54669687(-) A-I      intronic chr12:54662812(-) A-I      intronic chr12:54647998(-) A-I      intronic chr12:54669624(-) A-I      intronic chr12:54664653(-) A-I      intronic chr12:54638959(-) A-I      intronic chr12:54658118(-) A-I      intronic chr12:54642987(-) A-I      intronic chr12:54665311(-) A-I      intronic chr12:54671073(-) A-I      intronic chr12:54639463(-) A-I      intronic chr12:54650740(-) A-I      intronic chr12:54662922(-) A-I      intronic chr12:54669607(-) A-I      intronic chr12:54658013(-) A-I      intronic chr12:54664307(-) A-I      intronic chr12:54658121(-) A-I      intronic chr12:54661682(-) A-I      intronic chr12:54641800(-) A-I      intronic chr12:54658527(-) A-I      intronic chr12:54671261(-) A-I      intronic chr12:54647683(-) A-I      intronic chr12:54659755(-) A-I      intronic chr12:54641123(-) A-I      intronic chr12:54661736(-) A-I      intronic chr12:54669730(-) A-I      intronic chr12:54657539(-) A-I      intronic chr12:54647429(-) A-I      intronic chr12:54658002(-) A-I      intronic chr12:54669698(-) A-I      intronic chr12:54641769(-) A-I      intronic chr12:54669586(-) A-I      intronic chr12:54638871(-) A-I      intronic chr12:54647623(-) A-I      intronic chr12:54647455(-) A-I      intronic chr12:54669688(-) A-I      intronic chr12:54668602(-) A-I      intronic chr12:54654031(-) A-I      intronic chr12:54641829(-) A-I      intronic chr12:54641741(-) A-I      intronic chr12:54658012(-) A-I      intronic chr12:54642965(-) A-I      intronic chr12:54668534(-) A-I      intronic chr12:54662877(-) A-I      intronic chr12:54663311(-) A-I      intronic chr12:54669105(-) A-I      intronic chr12:54661494(-) A-I      intronic chr12:54641232(-) A-I      intronic chr12:54668693(-) A-I      intronic chr12:54647016(-) A-I      intronic chr12:54641789(-) A-I      intronic chr12:54664312(-) A-I      intronic chr12:54661816(-) A-I      intronic chr12:54662802(-) A-I      intronic chr12:54668473(-) A-I      intronic chr12:54647619(-) A-I      intronic chr12:54650674(-) A-I      intronic chr12:54663042(-) A-I      intronic chr12:54658119(-) A-I      intronic chr12:54664618(-) A-I      intronic chr12:54647027(-) A-I      intronic chr12:54647830(-) A-I      intronic chr12:54658056(-) A-I      intronic chr12:54667026(-) A-I      intronic chr12:54668718(-) A-I      intronic chr12:54648002(-) A-I      intronic chr12:54663225(-) A-I      intronic chr12:54659664(-) A-I      intronic chr12:54647682(-) A-I      intronic chr12:54669164(-) A-I      intronic chr12:54647403(-) A-I      intronic chr12:54658015(-) A-I      intronic chr12:54648063(-) A-I      intronic chr12:54650671(-) A-I      intronic chr12:54662855(-) A-I      intronic chr12:54634300(-) A-I      3'UTR chr12:54634284(-) A-I      3'UTR chr12:54634242(-) A-I      3'UTR chr12:54631717(-) A-I      3'UTR chr12:54627798(-) A-I      3'UTR chr12:54627639(-) A-I      3'UTR chr12:54627497(-) A-I      3'UTR chr12:54627547(-) A-I      3'UTR chr12:54627541(-) A-I      3'UTR chr12:54632050(-) A-I      3'UTR chr12:54627600(-) A-I      3'UTR chr12:54629209(-) A-I      3'UTR chr12:54631874(-) A-I      3'UTR chr12:54631891(-) A-I      3'UTR chr12:54627638(-) A-I      3'UTR chr12:54634257(-) A-I      3'UTR chr12:54631719(-) A-I      3'UTR chr12:54631722(-) A-I      3'UTR chr12:54627613(-) A-I      3'UTR chr12:54631782(-) A-I      3'UTR chr12:54631731(-) A-I      3'UTR chr12:54634283(-) A-I      3'UTR chr12:54634306(-) A-I      3'UTR chr12:54632059(-) A-I      3'UTR chr12:54627458(-) A-I      3'UTR chr12:54631988(-) A-I      3'UTR chr12:54627880(-) A-I      3'UTR chr12:54627877(-) A-I      3'UTR chr12:54627455(-) A-I      3'UTR chr12:54634302(-) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CBX5	chr12:54631988(-) A-I exon 3'UTR    15258596 chr12:54632050(-) A-I exon 3'UTR    15258596 chr12:54632059(-) A-I exon 3'UTR    15258596 chr12:54634182(-) A-I exon 3'UTR    15258596 chr12:54628230(-) T-G exon 3'UTR    21725310 chr12:54629209(-) A-G exon 3'UTR    21725310   //22484847 chr12:54634283(-) A-G exon 3'UTR    21725310   //22484847 chr12:54627458(-) A-G exon 3'UTR    22484847 chr12:54627480(-) A-G exon 3'UTR    22484847 chr12:54631719(-) A-G exon 3'UTR    22484847 chr12:54634284(-) A-G exon 3'UTR    22484847 chr12:54634300(-) A-G exon 3'UTR    22484847 chr12:54634306(-) A-G exon 3'UTR    22484847 chr12:54669105(-) A-G intron -    22484847 chr12:54669688(-) A-G intron -    22484847 chr12:54627638(-) A-G exon 3'UTR    22484847 chr12:54627639(-) A-G exon 3'UTR    22484847 chr12:54631782(-) A-G exon 3'UTR    22484847 chr12:54634236(-) A-G exon 3'UTR    22484847 chr12:54634242(-) A-G exon 3'UTR    22484847 chr12:54641232(-) A-G intron -    22484847 chr12:54642965(-) A-G intron -    22484847 chr12:54642987(-) A-G intron -    22484847 chr12:54647014(-) A-G intron -    22484847 chr12:54647016(-) A-G intron -    22484847 chr12:54647623(-) A-G intron -    22484847 chr12:54647728(-) A-G intron -    22484847 chr12:54647830(-) A-G intron -    22484847 chr12:54654990(-) C-T intron -    22484847 chr12:54657663(-) A-G intron -    22484847 chr12:54658002(-) A-G intron -    22484847 chr12:54658012(-) A-G intron -    22484847 chr12:54658013(-) A-G intron -    22484847 chr12:54658118(-) A-G intron -    22484847 chr12:54658119(-) A-G intron -    22484847 chr12:54658140(-) A-G intron -    22484847 chr12:54658527(-) A-G intron -    22484847 chr12:54659648(-) A-G intron -    22484847 chr12:54659664(-) A-G intron -    22484847 chr12:54659755(-) A-G intron -    22484847 chr12:54661816(-) A-G intron -    22484847 chr12:54662802(-) A-G intron -    22484847 chr12:54662812(-) A-G intron -    22484847 chr12:54662877(-) A-G intron -    22484847 chr12:54663311(-) A-G intron -    22484847 chr12:54664312(-) A-G intron -    22484847 chr12:54665247(-) A-G intron -    22484847 chr12:54665248(-) A-G intron -    22484847 chr12:54665311(-) A-G intron -    22484847 chr12:54668575(-) A-G intron -    22484847 chr12:54668602(-) A-G intron -    22484847 chr12:54668612(-) A-G intron -    22484847 chr12:54668693(-) A-G intron -    22484847 chr12:54668718(-) A-G intron -    22484847 chr12:54669154(-) A-G intron -    22484847 chr12:54669297(-) A-G intron -    22484847 chr12:54669607(-) A-G intron -    22484847 chr12:54669662(-) A-G intron -    22484847 chr12:54669698(-) A-G intron -    22484847 chr12:54671073(-) A-G intron -    22484847 chr12:54671080(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CBX5	chr12:54625669-54625670(-) m6A 3'UTR       27773535 chr12:54625730-54625731(-) m6A 3'UTR       27773535 chr12:54625989-54625990(-) m6A 3'UTR       - chr12:54626093-54626094(-) m6A 3'UTR       - chr12:54626099-54626100(-) m6A 3'UTR       - chr12:54633172-54633173(-) m6A 3'UTR       24981863 chr12:54633388-54633389(-) Y 3'UTR       25219674 chr12:54635447-54635448(-) m6A 3'UTR       24284625//27773535 chr12:54635552-54635553(-) m6A CDS//exon       24284625//24981863//28052920//27773535//27371828//22608085 chr12:54635566-54635567(-) m6A CDS//exon       24284625//24981863//28052920//27773535//27371828//22608085 chr12:54635601-54635602(-) m6A CDS//exon       24284625//24981863//28052920//27773535//27371828//22608085 chr12:54635683-54635684(-) m6A CDS//exon       24284625//24981863//28052920//27773535//27371828//22608085 chr12:54639950-54639951(-) Am CDS//exon       - chr12:54639957-54639958(-) m6A CDS//exon       24981863//27773535//27371828//22608085 chr12:54639963-54639964(-) m6A CDS//exon       24981863//27773535//27371828//22608085 chr12:54645861-54645862(-) m6A CDS//exon       24981863//27773535//27371828 chr12:54645908-54645909(-) m6A CDS//exon       24981863//27773535 chr12:54645981-54645982(-) m6A CDS//exon       24981863//27773535 chr12:54645992-54645993(-) m6A CDS//exon       24981863//27773535 chr12:54646266-54646267(-) m6A exon//intron       24981863 chr12:54651335-54651336(-) m6A CDS       24209618//24981863//27773535 chr12:54651354-54651355(-) m6A CDS       24209618//24981863//27773535//22575960 chr12:54651412-54651413(-) m6A CDS       24209618//24981863//27773535//22575960 chr12:54651421-54651422(-) m6A CDS       24209618//24981863//27773535//22575960 chr12:54651473-54651474(-) m6A 5'UTR       24209618//24981863//27773535//22575960 chr12:54651917-54651918(-) m6A 5'UTR//intron       24209618//24981863//27773535//22575960 chr12:54651945-54651946(-) m6A 5'UTR//intron       24209618 chr12:54653275-54653276(-) m6A 5'UTR//intron       24981863 chr12:54653305-54653306(-) m6A 5'UTR//intron       24981863 chr12:54653351-54653352(-) m6A 5'UTR//intron       24209618//24981863//22575960 chr12:54653357-54653358(-) m6A 5'UTR//intron       24209618//24981863//22575960 chr12:54673831-54673832(-) m6A 5'UTR//exon       24209618//24981863//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-29b-3p	Cytoplasm HeLa cells     28185889 Cytoplasm Hepatic carcinoma cells (Huh-7)     29253196 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Urine     26576778 Exosome HCC tissues     30542726 Exosome Saliva     19627513 Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Epithelial cells|Seminal fluid|Tongue tissue     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Hela cells|NIH-3T3 cells     17204650 Nucleus HeLa cells     28185889 Nucleus Hepatic carcinoma cells (Huh-7)     29253196 Nucleus HeLa cells     30006350 Nucleus Nasopharyngeal carcinoma cells     20498841
	CBX5	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HeLa-S3 cells|K562 cells     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-29b-3p	Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug resistant Phenyl gallate 333279 Drug resistant N-[(4R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris(3-aminopropoxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentyl]octan-1-amine 24205348 Drug sensitive 8-Hydroxyquinoline 1923 Drug resistant (R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug sensitive Acid Alizarine Red B 135565636 Drug resistant 2-Acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 Drug resistant 1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug resistant 4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug resistant naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)- - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-29b-3p	Formaldehyde 712 Drug interaction    RC00001120 Oxaliplatine 6857599 Drug interaction    RC00001140 Gemcitabine 60750 Drug interaction    RC00001131 Progesterone 5994 Drug interaction    RC00001126 D-Glucose 5793 Drug interaction    RC00001125 Eloxatine 5310940 Drug interaction    RC00001139 Imatinib 5291 Drug interaction    RC00001124 Decitabine 451668 Drug interaction    RC00001137 Docosahexaenoic acid 445580 Drug interaction    RC00001136 Trichostatin A 444732 Drug interaction    RC00001135 Cyclopamine 442972 Drug interaction    RC00001134 Bortezomib 387447 Drug interaction    RC00001133 Etoposide 36462 Drug interaction    RC00001130 Paclitaxel 36314 Drug interaction    RC00001129 5-Fluorouracil 3385 Drug interaction    RC00001123 Enoxacin 3229 Drug interaction    RC00001122 Doxorubicin 31703 Drug interaction    RC00001128 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001121 Tamoxifen 2733526 Drug interaction    RC00001138 Ixazomib 25183872 Drug interaction    RC00001144 Navitoclax 24978538 Drug interaction    RC00001143 Ampligen & InterferonalphaA 16197265 Drug interaction    RC00001142 Leucovorin 135403648 Drug interaction    RC00001145 Ginsenoside Rh2 119307 Drug interaction    RC00001132 Carfilzomib 11556711 Drug interaction    RC00001141 Androstanolone 10635 Drug interaction    RC00001127 Chemotherapy - Drug interaction    RC00001146 5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00001147 Glucocorticoid - Drug interaction    RC00001148 Testosterone + 1,25-Dihydroxyvitamin D3 - Drug interaction    RC00001149 Trastuzumab - Drug interaction    RC00001150

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-29b-3p	Bortezomib 387447       30728351

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-29b-3p
Interactor2: CBX5

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).